Long-term quiescent fibroblast cells transit into senescence.

Long-term quiescent fibroblast cells transit into senescence.

Cellular senescence is described to be a consequence of telomere erosion during the replicative life span of primary human cells. Quiescence should therefore not contribute to cellular aging but rather extend lifespan. Here we tested this hypothesis and demonstrate that cultured long-term quiescent...

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Bibliographic Details
Main Authors: Shiva Marthandan, Steffen Priebe, Peter Hemmerich, Karolin Klement, Stephan Diekmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4274099?pdf=render

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