NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy
Diabetic cardiomyopathy (DCM), a serious diabetic complication, is a kind of low-grade inflammatory cardiovascular disorder. Due to the high risk of morbidity and mortality, DCM has demanded the attention of medical researchers worldwide. The pathophysiological nature of DCM is intricate, and the ge...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/18/10632 |
| _version_ | 1797487250920964096 |
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| author | Lixia Zhang Chenchen Ai Ming Bai Jinglei Niu Zheng Zhang |
| author_facet | Lixia Zhang Chenchen Ai Ming Bai Jinglei Niu Zheng Zhang |
| author_sort | Lixia Zhang |
| collection | DOAJ |
| description | Diabetic cardiomyopathy (DCM), a serious diabetic complication, is a kind of low-grade inflammatory cardiovascular disorder. Due to the high risk of morbidity and mortality, DCM has demanded the attention of medical researchers worldwide. The pathophysiological nature of DCM is intricate, and the genesis and development of which are a consequence of the coaction of many factors. However, the exact pathogenesis mechanism of DCM remains unclear. Pyroptosis is a newly identified programmed cell death (PCD) that is directly related to gasdermin D(GSDMD). It is characterized by pore formation on the cell plasma membrane, the release of inflammatory mediators, and cell lysis. The initiation of pyroptosis is closely correlated with NOD-like receptor 3 (NLRP3) activation, which activates caspase-1 and promotes the cleaving of GSDMD. In addition to adjusting the host’s immune defense, NLRP3 inflammasome/pyroptosis plays a critical role in controlling the systemic inflammatory response. Recent evidence has indicated that NLRP3 inflammasome/pyroptosis has a strong link with DCM. Targeting the activation of NLRP3 inflammasome or pyroptosis may be a hopeful therapeutic strategy for DCM. The focus of this review is to summarize the relevant mechanisms of pyroptosis and the relative contributions in DCM, highlighting the potential therapeutic targets in this field. |
| first_indexed | 2024-03-09T23:44:58Z |
| format | Article |
| id | doaj.art-a3ed781c852a4866bc01a60d7f16dcfa |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:44:58Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a3ed781c852a4866bc01a60d7f16dcfa2023-11-23T16:45:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123181063210.3390/ijms231810632NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic CardiomyopathyLixia Zhang0Chenchen Ai1Ming Bai2Jinglei Niu3Zheng Zhang4The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, ChinaCardiovascular Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, ChinaDiabetic cardiomyopathy (DCM), a serious diabetic complication, is a kind of low-grade inflammatory cardiovascular disorder. Due to the high risk of morbidity and mortality, DCM has demanded the attention of medical researchers worldwide. The pathophysiological nature of DCM is intricate, and the genesis and development of which are a consequence of the coaction of many factors. However, the exact pathogenesis mechanism of DCM remains unclear. Pyroptosis is a newly identified programmed cell death (PCD) that is directly related to gasdermin D(GSDMD). It is characterized by pore formation on the cell plasma membrane, the release of inflammatory mediators, and cell lysis. The initiation of pyroptosis is closely correlated with NOD-like receptor 3 (NLRP3) activation, which activates caspase-1 and promotes the cleaving of GSDMD. In addition to adjusting the host’s immune defense, NLRP3 inflammasome/pyroptosis plays a critical role in controlling the systemic inflammatory response. Recent evidence has indicated that NLRP3 inflammasome/pyroptosis has a strong link with DCM. Targeting the activation of NLRP3 inflammasome or pyroptosis may be a hopeful therapeutic strategy for DCM. The focus of this review is to summarize the relevant mechanisms of pyroptosis and the relative contributions in DCM, highlighting the potential therapeutic targets in this field.https://www.mdpi.com/1422-0067/23/18/10632NLRP3 inflammasomepyroptosisdiabetic cardiomyopathyinhibitor |
| spellingShingle | Lixia Zhang Chenchen Ai Ming Bai Jinglei Niu Zheng Zhang NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy International Journal of Molecular Sciences NLRP3 inflammasome pyroptosis diabetic cardiomyopathy inhibitor |
| title | NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy |
| title_full | NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy |
| title_fullStr | NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy |
| title_full_unstemmed | NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy |
| title_short | NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy |
| title_sort | nlrp3 inflammasome pyroptosis a key driving force in diabetic cardiomyopathy |
| topic | NLRP3 inflammasome pyroptosis diabetic cardiomyopathy inhibitor |
| url | https://www.mdpi.com/1422-0067/23/18/10632 |
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