Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and Pakistan
Summary: We aimed to establish if enteric permeability was associated with similar biological processes in children recovering from hospitalization and relatively healthy children in the community. Extreme gradient boosted models predicting the lactulose-rhamnose ratio (LRR), a biomarker of enteric...
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| Format: | Article |
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Elsevier
2023-08-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223013718 |
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| author | Kirkby D. Tickell Donna M. Denno Ali Saleem Zaubina Kazi Benson O. Singa Catherine Achieng Charles Mutinda Barbra A. Richardson Kristjana H. Ásbjörnsdóttir Stephen E. Hawes James A. Berkley Judd L. Walson |
| author_facet | Kirkby D. Tickell Donna M. Denno Ali Saleem Zaubina Kazi Benson O. Singa Catherine Achieng Charles Mutinda Barbra A. Richardson Kristjana H. Ásbjörnsdóttir Stephen E. Hawes James A. Berkley Judd L. Walson |
| author_sort | Kirkby D. Tickell |
| collection | DOAJ |
| description | Summary: We aimed to establish if enteric permeability was associated with similar biological processes in children recovering from hospitalization and relatively healthy children in the community. Extreme gradient boosted models predicting the lactulose-rhamnose ratio (LRR), a biomarker of enteric permeability, using 7,500 plasma proteins and 34 fecal biomarkers of enteric infection among 89 hospitalized and 60 community children aged 2–23 months were built. The R2 values were calculated in test sets. The models performed better among community children (R2: 0.27 [min-max: 0.19, 0.53]) than hospitalized children (R2: 0.07 [min-max: 0.03, 0.11]). In the community, LRR was associated with biomarkers of humoral antimicrobial and cellular lipopolysaccharide responses and inversely associated with anti-inflammatory and innate immunological responses. Among hospitalized children, the selected biomarkers had few shared functions. This suggests enteric permeability among community children was associated with a host response to pathogens, but this association was not observed among hospitalized children. |
| first_indexed | 2024-03-12T21:18:04Z |
| format | Article |
| id | doaj.art-a3ed7ed6e599437795df8c45ab9e7660 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T21:18:04Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-a3ed7ed6e599437795df8c45ab9e76602023-07-29T04:35:43ZengElsevieriScience2589-00422023-08-01268107294Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and PakistanKirkby D. Tickell0Donna M. Denno1Ali Saleem2Zaubina Kazi3Benson O. Singa4Catherine Achieng5Charles Mutinda6Barbra A. Richardson7Kristjana H. Ásbjörnsdóttir8Stephen E. Hawes9James A. Berkley10Judd L. Walson11Department of Global Health, University of Washington, Seattle, WA, USA; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya; Corresponding authorDepartment of Global Health, University of Washington, Seattle, WA, USA; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, KenyaThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya; Aga Khan University, Karachi, PakistanThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya; Aga Khan University, Karachi, PakistanThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya; Kenya Medical Research Institute, Nairobi, KenyaThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya; Kenya Medical Research Institute, Nairobi, KenyaThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya; Kenya Medical Research Institute, Nairobi, KenyaDepartment of Biostatistics, University of Washington, Seattle, WA, USADepartment of Epidemiology, University of Iceland, Reykjavik, IcelandDepartment of Epidemiology, University of Washington, Seattle, WA, USAThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya; Nuffield Department of Medicine, University of Oxford, Oxford, UKDepartment of Global Health, University of Washington, Seattle, WA, USA; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, KenyaSummary: We aimed to establish if enteric permeability was associated with similar biological processes in children recovering from hospitalization and relatively healthy children in the community. Extreme gradient boosted models predicting the lactulose-rhamnose ratio (LRR), a biomarker of enteric permeability, using 7,500 plasma proteins and 34 fecal biomarkers of enteric infection among 89 hospitalized and 60 community children aged 2–23 months were built. The R2 values were calculated in test sets. The models performed better among community children (R2: 0.27 [min-max: 0.19, 0.53]) than hospitalized children (R2: 0.07 [min-max: 0.03, 0.11]). In the community, LRR was associated with biomarkers of humoral antimicrobial and cellular lipopolysaccharide responses and inversely associated with anti-inflammatory and innate immunological responses. Among hospitalized children, the selected biomarkers had few shared functions. This suggests enteric permeability among community children was associated with a host response to pathogens, but this association was not observed among hospitalized children.http://www.sciencedirect.com/science/article/pii/S2589004223013718PediatricsPatient characteristicsOutcomeProteomics |
| spellingShingle | Kirkby D. Tickell Donna M. Denno Ali Saleem Zaubina Kazi Benson O. Singa Catherine Achieng Charles Mutinda Barbra A. Richardson Kristjana H. Ásbjörnsdóttir Stephen E. Hawes James A. Berkley Judd L. Walson Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and Pakistan iScience Pediatrics Patient characteristics Outcome Proteomics |
| title | Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and Pakistan |
| title_full | Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and Pakistan |
| title_fullStr | Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and Pakistan |
| title_full_unstemmed | Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and Pakistan |
| title_short | Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and Pakistan |
| title_sort | plasma proteomic signatures of enteric permeability among hospitalized and community children in kenya and pakistan |
| topic | Pediatrics Patient characteristics Outcome Proteomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223013718 |
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