The Preclinical Pharmacological Study of a Novel Long-Acting Local Anesthetic, a Fixed-Dose Combination of QX-OH/Levobupivacaine, in Rats

The Preclinical Pharmacological Study of a Novel Long-Acting Local Anesthetic, a Fixed-Dose Combination of QX-OH/Levobupivacaine, in Rats

Introduction: Previous studies demonstrated that 35 mM QX-OH/10 mM Levobupivacaine (LL-1), a fixed-dose combination, produced a long-acting effect in rat local anesthesia models. All preclinical pharmacodynamic results indicated that LL-1 had potential for postsurgical pain treatment. The objective...

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Bibliographic Details
Main Authors: YuJun Zhang, QinQin Yin, DeYing Gong, Yi Kang, Jun Yang, Jin Liu, WenSheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
preclinical drug development
preclinical pharmacokinetics
long-acting local anesthetic
fixed-dose combination
QX-OH
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00895/full

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