The Association between rs4541843 Polymorphism in miR-182 and Diabetes Mellitus
Background and purpose: Diabetes Mellitus is one of the most common endocrine diseases. The prevalence of type 2 diabetes is higher than other types, accounting for 85-90% of all diabetic cases. The current research aimed at investigating the association between rs4541843 in miR-182 and type 2 diabe...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2020-05-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-13777-en.html |
| _version_ | 1797944088875499520 |
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| author | Arezu Abdi Maryam Peymani |
| author_facet | Arezu Abdi Maryam Peymani |
| author_sort | Arezu Abdi |
| collection | DOAJ |
| description | Background and purpose: Diabetes Mellitus is one of the most common endocrine diseases. The prevalence of type 2 diabetes is higher than other types, accounting for 85-90% of all diabetic cases. The current research aimed at investigating the association between rs4541843 in miR-182 and type 2 diabetes.
Materials and methods: In this case-control study, healthy individuals (n=196) and type 2 diabetic patients (n=199) were randomly selected from a target population in Isfahan, Iran. The genotypes for the polymorphism were determined by PCR-RFLP method and the results were confirmed by sequencing. Then, the frequency of the genotypes and alleles were analyzed to determine the association between rs4541843 in miR-182 and the risk of type 2 diabetes, sex, and age at disease onset.
Results: The study showed no significant difference between different genotypes in healthy individuals and diabetic patients (P<0.05). Also, no significant association was found between different genotypes of this polymorphism and risk of diabetes considering GG genotype as the reference genotype (P< 0.05).
Conclusion: Due to the lack of association between the rs4541843 in miR-182 and risk of diabetes in this population, this polymorphism cannot be used to screen diabetic patients in the target population. Further studies are needed to evaluate the importance of this polymorphism in different populations. |
| first_indexed | 2024-04-10T20:34:06Z |
| format | Article |
| id | doaj.art-a3edbbc9974347c6a48a48c62ba9d809 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:34:06Z |
| publishDate | 2020-05-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-a3edbbc9974347c6a48a48c62ba9d8092023-01-25T05:01:54ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792020-05-0130185137142The Association between rs4541843 Polymorphism in miR-182 and Diabetes MellitusArezu Abdi0Maryam Peymani1 MSc in Molecular Genetics, Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Assistant Professor, Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Background and purpose: Diabetes Mellitus is one of the most common endocrine diseases. The prevalence of type 2 diabetes is higher than other types, accounting for 85-90% of all diabetic cases. The current research aimed at investigating the association between rs4541843 in miR-182 and type 2 diabetes. Materials and methods: In this case-control study, healthy individuals (n=196) and type 2 diabetic patients (n=199) were randomly selected from a target population in Isfahan, Iran. The genotypes for the polymorphism were determined by PCR-RFLP method and the results were confirmed by sequencing. Then, the frequency of the genotypes and alleles were analyzed to determine the association between rs4541843 in miR-182 and the risk of type 2 diabetes, sex, and age at disease onset. Results: The study showed no significant difference between different genotypes in healthy individuals and diabetic patients (P<0.05). Also, no significant association was found between different genotypes of this polymorphism and risk of diabetes considering GG genotype as the reference genotype (P< 0.05). Conclusion: Due to the lack of association between the rs4541843 in miR-182 and risk of diabetes in this population, this polymorphism cannot be used to screen diabetic patients in the target population. Further studies are needed to evaluate the importance of this polymorphism in different populations.http://jmums.mazums.ac.ir/article-1-13777-en.htmltype 2 diabetespolymorphismmir-182 |
| spellingShingle | Arezu Abdi Maryam Peymani The Association between rs4541843 Polymorphism in miR-182 and Diabetes Mellitus Journal of Mazandaran University of Medical Sciences type 2 diabetes polymorphism mir-182 |
| title | The Association between rs4541843 Polymorphism in
miR-182 and Diabetes Mellitus |
| title_full | The Association between rs4541843 Polymorphism in
miR-182 and Diabetes Mellitus |
| title_fullStr | The Association between rs4541843 Polymorphism in
miR-182 and Diabetes Mellitus |
| title_full_unstemmed | The Association between rs4541843 Polymorphism in
miR-182 and Diabetes Mellitus |
| title_short | The Association between rs4541843 Polymorphism in
miR-182 and Diabetes Mellitus |
| title_sort | association between rs4541843 polymorphism in mir 182 and diabetes mellitus |
| topic | type 2 diabetes polymorphism mir-182 |
| url | http://jmums.mazums.ac.ir/article-1-13777-en.html |
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