Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in non-diseased lungs from donors of ~30 weeks gestation,~3 years and ~30 years. We ma...

Full description

Bibliographic Details
Main Authors: Allen Wang, Joshua Chiou, Olivier B Poirion, Justin Buchanan, Michael J Valdez, Jamie M Verheyden, Xiaomeng Hou, Parul Kudtarkar, Sharvari Narendra, Jacklyn M Newsome, Minzhe Guo, Dina A Faddah, Kai Zhang, Randee E Young, Justinn Barr, Eniko Sajti, Ravi Misra, Heidie Huyck, Lisa Rogers, Cory Poole, Jeffery A Whitsett, Gloria Pryhuber, Yan Xu, Kyle J Gaulton, Sebastian Preissl, Xin Sun, NHLBI LungMap Consortium
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
lung
gene regulation
single cell RNA/ATAC-seq
cis-regulatory elements
human sequence variants
COVID-19
Online Access:https://elifesciences.org/articles/62522

Internet

https://elifesciences.org/articles/62522

Similar Items