Role of genetic testing in the management of indeterminate thyroid nodules in the Indian setting
The increased detection of thyroid nodules in the human population has led to an increase in the number of thyroid surgeries without an improvement in survival outcomes. Though the choice for surgery is straightforward in malignant thyroid nodules, the decision is far more complex in those nodules t...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2024;volume=28;issue=1;spage=3;epage=10;aulast=Riju |
| _version_ | 1797246468106485760 |
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| author | Jeyashanth Riju Nihal Thomas Thomas V Paul Deepak Thomas Abraham Rekha Pai Anne J Prabhu Paul Mazhuvanchary Jacob Remya Rajan Rajiv C Michael Amit Jiwan Tirkey Natarajan Ramalingam Hesarghatta S Asha Nitin Kapoor |
| author_facet | Jeyashanth Riju Nihal Thomas Thomas V Paul Deepak Thomas Abraham Rekha Pai Anne J Prabhu Paul Mazhuvanchary Jacob Remya Rajan Rajiv C Michael Amit Jiwan Tirkey Natarajan Ramalingam Hesarghatta S Asha Nitin Kapoor |
| author_sort | Jeyashanth Riju |
| collection | DOAJ |
| description | The increased detection of thyroid nodules in the human population has led to an increase in the number of thyroid surgeries without an improvement in survival outcomes. Though the choice for surgery is straightforward in malignant thyroid nodules, the decision is far more complex in those nodules that get categorized into indeterminate thyroid nodules (ITN) by fine needle aspiration. Therefore, there is a pressing need to develop a tool that will aid in decision-making among the ITN. In this context, the development of various molecular testing (MT) panels has helped to confirm or rule out malignancy, reducing unnecessary surgeries and potentially guiding the extent of surgery as well. Currently, such tests are widely used among the Western population but these MT panels are not used by the South Asian population because of non-availability of validated panels and the high cost involved. There is a need to develop a suitable panel which is population-specific and validate the same. In this review, we would focus on current trends in the management of ITN among the South Asian population and how to develop a novel MT panel which is cost-effective, with high diagnostic accuracy obviating the need for expensive panels that already exist. |
| first_indexed | 2024-04-24T19:43:16Z |
| format | Article |
| id | doaj.art-a3ee2d8099294f53a2bb570d136e8043 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-04-24T19:43:16Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-a3ee2d8099294f53a2bb570d136e80432024-03-25T10:27:50ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102024-01-0128131010.4103/ijem.ijem_415_23Role of genetic testing in the management of indeterminate thyroid nodules in the Indian settingJeyashanth RijuNihal ThomasThomas V PaulDeepak Thomas AbrahamRekha PaiAnne J PrabhuPaul Mazhuvanchary JacobRemya RajanRajiv C MichaelAmit Jiwan TirkeyNatarajan RamalingamHesarghatta S AshaNitin KapoorThe increased detection of thyroid nodules in the human population has led to an increase in the number of thyroid surgeries without an improvement in survival outcomes. Though the choice for surgery is straightforward in malignant thyroid nodules, the decision is far more complex in those nodules that get categorized into indeterminate thyroid nodules (ITN) by fine needle aspiration. Therefore, there is a pressing need to develop a tool that will aid in decision-making among the ITN. In this context, the development of various molecular testing (MT) panels has helped to confirm or rule out malignancy, reducing unnecessary surgeries and potentially guiding the extent of surgery as well. Currently, such tests are widely used among the Western population but these MT panels are not used by the South Asian population because of non-availability of validated panels and the high cost involved. There is a need to develop a suitable panel which is population-specific and validate the same. In this review, we would focus on current trends in the management of ITN among the South Asian population and how to develop a novel MT panel which is cost-effective, with high diagnostic accuracy obviating the need for expensive panels that already exist.http://www.ijem.in/article.asp?issn=2230-8210;year=2024;volume=28;issue=1;spage=3;epage=10;aulast=Rijuasiacytodiagnosisindiamolecular diagnostic techniquemolecular testingthyroid nodule |
| spellingShingle | Jeyashanth Riju Nihal Thomas Thomas V Paul Deepak Thomas Abraham Rekha Pai Anne J Prabhu Paul Mazhuvanchary Jacob Remya Rajan Rajiv C Michael Amit Jiwan Tirkey Natarajan Ramalingam Hesarghatta S Asha Nitin Kapoor Role of genetic testing in the management of indeterminate thyroid nodules in the Indian setting Indian Journal of Endocrinology and Metabolism asia cytodiagnosis india molecular diagnostic technique molecular testing thyroid nodule |
| title | Role of genetic testing in the management of indeterminate thyroid nodules in the Indian setting |
| title_full | Role of genetic testing in the management of indeterminate thyroid nodules in the Indian setting |
| title_fullStr | Role of genetic testing in the management of indeterminate thyroid nodules in the Indian setting |
| title_full_unstemmed | Role of genetic testing in the management of indeterminate thyroid nodules in the Indian setting |
| title_short | Role of genetic testing in the management of indeterminate thyroid nodules in the Indian setting |
| title_sort | role of genetic testing in the management of indeterminate thyroid nodules in the indian setting |
| topic | asia cytodiagnosis india molecular diagnostic technique molecular testing thyroid nodule |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2024;volume=28;issue=1;spage=3;epage=10;aulast=Riju |
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