Identification of Novel Microsatellite Markers Flanking the SMN1 and SMN2 Duplicated Region and Inclusion Into a Single-Tube Tridecaplex Panel for Haplotype-Based Preimplantation Genetic Testing of Spinal Muscular Atrophy

Identification of Novel Microsatellite Markers Flanking the SMN1 and SMN2 Duplicated Region and Inclusion Into a Single-Tube Tridecaplex Panel for Haplotype-Based Preimplantation Genetic Testing of Spinal Muscular Atrophy

Preimplantation genetic testing for the monogenic disorder (PGT-M) spinal muscular atrophy (SMA) is significantly improved by supplementation of SMN1 deletion detection with marker-based linkage analysis. To expand the availability of informative markers for PGT-M of SMA, we identified novel non-dup...

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Bibliographic Details
Main Authors: Mingjue Zhao, Mulias Lian, Felicia S.H. Cheah, Arnold S.C. Tan, Anupriya Agarwal, Samuel S. Chong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
microsatellite
preimplantation genetic testing for monogenic disorders (PGT-M)
spinal muscular atrophy (SMA)
spinal motor neuron (SMN)
multiplex PCR
haplotype
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01105/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01105/full

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