An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection
Antimicrobial resistance to antibiotic treatment has significantly increased during recent years, causing this to become a worldwide public health problem. More than 70% of pathogenic bacteria are resistant to at least one of the currently used antibiotics. Polymyxin E (colistin) has recently been u...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/8/3/100 |
| _version_ | 1818900734452695040 |
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| author | Tatiana Pacheco Rosa-Helena Bustos Diana González Vivian Garzón Julio-Cesar García Daniela Ramírez |
| author_facet | Tatiana Pacheco Rosa-Helena Bustos Diana González Vivian Garzón Julio-Cesar García Daniela Ramírez |
| author_sort | Tatiana Pacheco |
| collection | DOAJ |
| description | Antimicrobial resistance to antibiotic treatment has significantly increased during recent years, causing this to become a worldwide public health problem. More than 70% of pathogenic bacteria are resistant to at least one of the currently used antibiotics. Polymyxin E (colistin) has recently been used as a “last line” therapy when treating Gram-negative multi-resistant bacteria. However, little is known about these molecules’ pharmacological use as they have been discontinued because of their high toxicity. Recent research has been focused on determining colistimethate sodium’s pharmacokinetic parameters to find the optimal dose for maintaining a suitable benefit−risk balance. This review has thus been aimed at describing the use of colistin on patients infected by multi-drug resistant bacteria and the importance of measuring this drug’s plasma levels in such patients. |
| first_indexed | 2024-12-19T20:08:34Z |
| format | Article |
| id | doaj.art-a3f0765141ac4aca830cc83dacb6002a |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-19T20:08:34Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-a3f0765141ac4aca830cc83dacb6002a2022-12-21T20:07:23ZengMDPI AGAntibiotics2079-63822019-07-018310010.3390/antibiotics8030100antibiotics8030100An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial InfectionTatiana Pacheco0Rosa-Helena Bustos1Diana González2Vivian Garzón3Julio-Cesar García4Daniela Ramírez5Evidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de la Sabana, Chía 140013, ColombiaEvidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de la Sabana, Chía 140013, ColombiaEvidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de la Sabana, Chía 140013, ColombiaEvidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de la Sabana, Chía 140013, ColombiaEvidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de la Sabana, Chía 140013, ColombiaFacultad de Medicina, Univesidad de La Sabana, Chía 140013, ColombiaAntimicrobial resistance to antibiotic treatment has significantly increased during recent years, causing this to become a worldwide public health problem. More than 70% of pathogenic bacteria are resistant to at least one of the currently used antibiotics. Polymyxin E (colistin) has recently been used as a “last line” therapy when treating Gram-negative multi-resistant bacteria. However, little is known about these molecules’ pharmacological use as they have been discontinued because of their high toxicity. Recent research has been focused on determining colistimethate sodium’s pharmacokinetic parameters to find the optimal dose for maintaining a suitable benefit−risk balance. This review has thus been aimed at describing the use of colistin on patients infected by multi-drug resistant bacteria and the importance of measuring this drug’s plasma levels in such patients.https://www.mdpi.com/2079-6382/8/3/100colistinantimicrobial resistanceGram-negative bacteriatherapeutic drug monitoring (TDM)multidrug-resistant (MDR)pandrug-resistant (PDR)extensive-drug resistant (XDR) |
| spellingShingle | Tatiana Pacheco Rosa-Helena Bustos Diana González Vivian Garzón Julio-Cesar García Daniela Ramírez An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection Antibiotics colistin antimicrobial resistance Gram-negative bacteria therapeutic drug monitoring (TDM) multidrug-resistant (MDR) pandrug-resistant (PDR) extensive-drug resistant (XDR) |
| title | An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection |
| title_full | An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection |
| title_fullStr | An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection |
| title_full_unstemmed | An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection |
| title_short | An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection |
| title_sort | approach to measuring colistin plasma levels regarding the treatment of multidrug resistant bacterial infection |
| topic | colistin antimicrobial resistance Gram-negative bacteria therapeutic drug monitoring (TDM) multidrug-resistant (MDR) pandrug-resistant (PDR) extensive-drug resistant (XDR) |
| url | https://www.mdpi.com/2079-6382/8/3/100 |
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