Pulse therapy: Opening new vistas in treatment of pemphigus
Pemphigus is comprised of a group of life-threatening autoimmune diseases that is characterized by circulating IgG antibodies targeting several types of keratinocyte antigens. After introduction of systemic steroids, survival has improved dramatically. However, mortality and morbidity were still ver...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
|
| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=3;spage=793;epage=798;aulast=Mustafi |
| _version_ | 1818085784851316736 |
|---|---|
| author | Subhasish Mustafi Rupam Sinha Samhita Hore Suman Sen Subhadeep Maity Pritha Ghosh |
| author_facet | Subhasish Mustafi Rupam Sinha Samhita Hore Suman Sen Subhadeep Maity Pritha Ghosh |
| author_sort | Subhasish Mustafi |
| collection | DOAJ |
| description | Pemphigus is comprised of a group of life-threatening autoimmune diseases that is characterized by circulating IgG antibodies targeting several types of keratinocyte antigens. After introduction of systemic steroids, survival has improved dramatically. However, mortality and morbidity were still very high due to side effects of steroids. Pulse therapy is defined as discontinuous/intermittent intravenous infusion of very high doses of corticosteroids along with certain immunosuppressive agents over a short period. This therapy was introduced to minimize the side effects of conventional corticosteroid therapy. The target is to achieve a faster response and stronger efficacy and to decrease the need for long-term use of systemic corticosteroids. As a result, this therapy has gained its popularity since three decades. The purpose of this article is to review the various available pulse therapy regimens with dosage, indications and contraindications and side effects. |
| first_indexed | 2024-12-10T20:15:18Z |
| format | Article |
| id | doaj.art-a3f13f5b86d84a32bcbe5c3231b436cb |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-10T20:15:18Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-a3f13f5b86d84a32bcbe5c3231b436cb2022-12-22T01:35:13ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632019-01-018379379810.4103/jfmpc.jfmpc_114_19Pulse therapy: Opening new vistas in treatment of pemphigusSubhasish MustafiRupam SinhaSamhita HoreSuman SenSubhadeep MaityPritha GhoshPemphigus is comprised of a group of life-threatening autoimmune diseases that is characterized by circulating IgG antibodies targeting several types of keratinocyte antigens. After introduction of systemic steroids, survival has improved dramatically. However, mortality and morbidity were still very high due to side effects of steroids. Pulse therapy is defined as discontinuous/intermittent intravenous infusion of very high doses of corticosteroids along with certain immunosuppressive agents over a short period. This therapy was introduced to minimize the side effects of conventional corticosteroid therapy. The target is to achieve a faster response and stronger efficacy and to decrease the need for long-term use of systemic corticosteroids. As a result, this therapy has gained its popularity since three decades. The purpose of this article is to review the various available pulse therapy regimens with dosage, indications and contraindications and side effects.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=3;spage=793;epage=798;aulast=MustafiCorticosteroidsimmunosuppressive agentspemphiguspulse therapy |
| spellingShingle | Subhasish Mustafi Rupam Sinha Samhita Hore Suman Sen Subhadeep Maity Pritha Ghosh Pulse therapy: Opening new vistas in treatment of pemphigus Journal of Family Medicine and Primary Care Corticosteroids immunosuppressive agents pemphigus pulse therapy |
| title | Pulse therapy: Opening new vistas in treatment of pemphigus |
| title_full | Pulse therapy: Opening new vistas in treatment of pemphigus |
| title_fullStr | Pulse therapy: Opening new vistas in treatment of pemphigus |
| title_full_unstemmed | Pulse therapy: Opening new vistas in treatment of pemphigus |
| title_short | Pulse therapy: Opening new vistas in treatment of pemphigus |
| title_sort | pulse therapy opening new vistas in treatment of pemphigus |
| topic | Corticosteroids immunosuppressive agents pemphigus pulse therapy |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=3;spage=793;epage=798;aulast=Mustafi |
| work_keys_str_mv | AT subhasishmustafi pulsetherapyopeningnewvistasintreatmentofpemphigus AT rupamsinha pulsetherapyopeningnewvistasintreatmentofpemphigus AT samhitahore pulsetherapyopeningnewvistasintreatmentofpemphigus AT sumansen pulsetherapyopeningnewvistasintreatmentofpemphigus AT subhadeepmaity pulsetherapyopeningnewvistasintreatmentofpemphigus AT prithaghosh pulsetherapyopeningnewvistasintreatmentofpemphigus |