Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: a randomized pilot study
Objective: To assess the efficacy and safety of artemether emulsion in patients with papulopustular rosacea. Methods: A total of 130 (randomized 1:1) were externally administered either artemether emulsion (1%) or metronidazole emulsion (3%) twice daily for 4 weeks with an open-label 8-week follow-u...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-11-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2019.1610549 |
| _version_ | 1797683668370587648 |
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| author | Guo-Jiang Wang Xiao-Yan Gao Yun Wu Hui-Qiong He Yue Yu Hai-Hong Qin Wen-Tong Shen |
| author_facet | Guo-Jiang Wang Xiao-Yan Gao Yun Wu Hui-Qiong He Yue Yu Hai-Hong Qin Wen-Tong Shen |
| author_sort | Guo-Jiang Wang |
| collection | DOAJ |
| description | Objective: To assess the efficacy and safety of artemether emulsion in patients with papulopustular rosacea. Methods: A total of 130 (randomized 1:1) were externally administered either artemether emulsion (1%) or metronidazole emulsion (3%) twice daily for 4 weeks with an open-label 8-week follow-up. The primary endpoints included the proportion of patients who achieved clinical effective responses, as well as erythema and papule and pustule score at week 4. Results: Numerically more patients achieved an effective response at week 4 with artemether emulsion (87.1%) than metronidazole emulsion (80.0%) (p > .05). Patients with artemether emulsion had comparable baseline erythema score (2.45 ± 0.67 versus 2.42 ± 0.70, p = .809) and papule and pustule score (2.11 ± 0.96 versus 2.32 ± 0.83, p = .264), but significantly lower papule and pustule score (0.21 ± 0.52 versus 0.42 ± 0.83, p = .001) and comparable erythema score (0.53 ± 0.88 versus 0.62 ± 0.88, p = .999) compared to patients with metronidazole emulsion at week 4. There was a significantly higher proportion of patients with metronidazole emulsion relapse compared to metronidazole emulsion during the open-label 8-week follow-up period (21.6% versus 2.4%, p < .01). Conclusions: Artemether emulsion improved papulopustular rosacea in the metronidazole emulsion group as early as 4 weeks, but its beneficial effect was maintained through the 8-week follow-up period compared to metronidazole emulsion. |
| first_indexed | 2024-03-12T00:18:21Z |
| format | Article |
| id | doaj.art-a3f441f05ad642cfbee22020f3176a49 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:18:21Z |
| publishDate | 2019-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-a3f441f05ad642cfbee22020f3176a492023-09-15T14:23:02ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532019-11-0130880981210.1080/09546634.2019.16105491610549Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: a randomized pilot studyGuo-Jiang Wang0Xiao-Yan Gao1Yun Wu2Hui-Qiong He3Yue Yu4Hai-Hong Qin5Wen-Tong Shen6Shanghai University of Medicine&Health Sciences, Pudong New AreaPudong New AreaShanghai University of Medicine&Health Sciences, Pudong New AreaShanghai University of Medicine&Health Sciences, Pudong New AreaShanghai University of Medicine&Health Sciences, Pudong New AreaShanghai University of Medicine&Health Sciences, Pudong New AreaShanghai University of Medicine&Health Sciences, Pudong New AreaObjective: To assess the efficacy and safety of artemether emulsion in patients with papulopustular rosacea. Methods: A total of 130 (randomized 1:1) were externally administered either artemether emulsion (1%) or metronidazole emulsion (3%) twice daily for 4 weeks with an open-label 8-week follow-up. The primary endpoints included the proportion of patients who achieved clinical effective responses, as well as erythema and papule and pustule score at week 4. Results: Numerically more patients achieved an effective response at week 4 with artemether emulsion (87.1%) than metronidazole emulsion (80.0%) (p > .05). Patients with artemether emulsion had comparable baseline erythema score (2.45 ± 0.67 versus 2.42 ± 0.70, p = .809) and papule and pustule score (2.11 ± 0.96 versus 2.32 ± 0.83, p = .264), but significantly lower papule and pustule score (0.21 ± 0.52 versus 0.42 ± 0.83, p = .001) and comparable erythema score (0.53 ± 0.88 versus 0.62 ± 0.88, p = .999) compared to patients with metronidazole emulsion at week 4. There was a significantly higher proportion of patients with metronidazole emulsion relapse compared to metronidazole emulsion during the open-label 8-week follow-up period (21.6% versus 2.4%, p < .01). Conclusions: Artemether emulsion improved papulopustular rosacea in the metronidazole emulsion group as early as 4 weeks, but its beneficial effect was maintained through the 8-week follow-up period compared to metronidazole emulsion.http://dx.doi.org/10.1080/09546634.2019.1610549artemether emulsionrosaceaefficacysafetyrelapse |
| spellingShingle | Guo-Jiang Wang Xiao-Yan Gao Yun Wu Hui-Qiong He Yue Yu Hai-Hong Qin Wen-Tong Shen Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: a randomized pilot study Journal of Dermatological Treatment artemether emulsion rosacea efficacy safety relapse |
| title | Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: a randomized pilot study |
| title_full | Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: a randomized pilot study |
| title_fullStr | Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: a randomized pilot study |
| title_full_unstemmed | Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: a randomized pilot study |
| title_short | Evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea: a randomized pilot study |
| title_sort | evaluation of the efficacy and tolerance of artemether emulsion for the treatment of papulopustular rosacea a randomized pilot study |
| topic | artemether emulsion rosacea efficacy safety relapse |
| url | http://dx.doi.org/10.1080/09546634.2019.1610549 |
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