Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer
Neutralizing antibodies (bNAbs) against HIV-1 are exclusively directed against the viral envelope protein (Env) and mainly target Env in a closed, prefusion state. Here, Yang et al. structurally characterize two heterologously-neutralizing CD4-binding site (CD4bs) antibodies isolated from sequential...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28424-3 |
| _version_ | 1818332007230341120 |
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| author | Zhi Yang Kim-Marie A. Dam Michael D. Bridges Magnus A. G. Hoffmann Andrew T. DeLaitsch Harry B. Gristick Amelia Escolano Rajeev Gautam Malcolm A. Martin Michel C. Nussenzweig Wayne L. Hubbell Pamela J. Bjorkman |
| author_facet | Zhi Yang Kim-Marie A. Dam Michael D. Bridges Magnus A. G. Hoffmann Andrew T. DeLaitsch Harry B. Gristick Amelia Escolano Rajeev Gautam Malcolm A. Martin Michel C. Nussenzweig Wayne L. Hubbell Pamela J. Bjorkman |
| author_sort | Zhi Yang |
| collection | DOAJ |
| description | Neutralizing antibodies (bNAbs) against HIV-1 are exclusively directed against the viral envelope protein (Env) and mainly target Env in a closed, prefusion state. Here, Yang et al. structurally characterize two heterologously-neutralizing CD4-binding site (CD4bs) antibodies isolated from sequentially immunized macaques, and show that these antibodies recognize the CD4bs on Env trimers in an „occluded-open‟ conformation between closed, as targeted by bNAbs, and fully-open, as recognized by CD4. |
| first_indexed | 2024-12-13T13:28:53Z |
| format | Article |
| id | doaj.art-a3f529a3512548c399bdcaadfab62202 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T13:28:53Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a3f529a3512548c399bdcaadfab622022022-12-21T23:44:13ZengNature PortfolioNature Communications2041-17232022-02-0113111410.1038/s41467-022-28424-3Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimerZhi Yang0Kim-Marie A. Dam1Michael D. Bridges2Magnus A. G. Hoffmann3Andrew T. DeLaitsch4Harry B. Gristick5Amelia Escolano6Rajeev Gautam7Malcolm A. Martin8Michel C. Nussenzweig9Wayne L. Hubbell10Pamela J. Bjorkman11Division of Biology and Biological Engineering, California Institute of TechnologyDivision of Biology and Biological Engineering, California Institute of TechnologyJules Stein Eye Institute, University of CaliforniaDivision of Biology and Biological Engineering, California Institute of TechnologyDivision of Biology and Biological Engineering, California Institute of TechnologyDivision of Biology and Biological Engineering, California Institute of TechnologyLaboratory of Molecular Immunology, The Rockefeller UniversityLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Molecular Immunology, The Rockefeller UniversityJules Stein Eye Institute, University of CaliforniaDivision of Biology and Biological Engineering, California Institute of TechnologyNeutralizing antibodies (bNAbs) against HIV-1 are exclusively directed against the viral envelope protein (Env) and mainly target Env in a closed, prefusion state. Here, Yang et al. structurally characterize two heterologously-neutralizing CD4-binding site (CD4bs) antibodies isolated from sequentially immunized macaques, and show that these antibodies recognize the CD4bs on Env trimers in an „occluded-open‟ conformation between closed, as targeted by bNAbs, and fully-open, as recognized by CD4.https://doi.org/10.1038/s41467-022-28424-3 |
| spellingShingle | Zhi Yang Kim-Marie A. Dam Michael D. Bridges Magnus A. G. Hoffmann Andrew T. DeLaitsch Harry B. Gristick Amelia Escolano Rajeev Gautam Malcolm A. Martin Michel C. Nussenzweig Wayne L. Hubbell Pamela J. Bjorkman Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer Nature Communications |
| title | Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer |
| title_full | Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer |
| title_fullStr | Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer |
| title_full_unstemmed | Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer |
| title_short | Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer |
| title_sort | neutralizing antibodies induced in immunized macaques recognize the cd4 binding site on an occluded open hiv 1 envelope trimer |
| url | https://doi.org/10.1038/s41467-022-28424-3 |
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