Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment
Scavenging excessively secreted cytokines from plasma is vital for treating cytokine storm syndrome (CSS). Therefore, appropriate adsorbent materials are highly desired for efficient and selectively capturing the plasma cytokines. For this purpose, injectable porous silicon particles (PSPs) are desi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-10-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202300037 |
| _version_ | 1797659527755071488 |
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| author | Ruogu Qi Shengliang Li Feng Li Junhua Mai Yu Wang Guixian Zhu Dechen Zhang Zheng Li Haifa Shen Jianliang Shen Xuewu Liu |
| author_facet | Ruogu Qi Shengliang Li Feng Li Junhua Mai Yu Wang Guixian Zhu Dechen Zhang Zheng Li Haifa Shen Jianliang Shen Xuewu Liu |
| author_sort | Ruogu Qi |
| collection | DOAJ |
| description | Scavenging excessively secreted cytokines from plasma is vital for treating cytokine storm syndrome (CSS). Therefore, appropriate adsorbent materials are highly desired for efficient and selectively capturing the plasma cytokines. For this purpose, injectable porous silicon particles (PSPs) are designed as scavenging adsorbents. The fabricated PSP features high porosity for large pore volume and high specific surface area. Polyethylene glycol is coated on the outer surface of PSP for a longer body circulation time, while antibodies are immobilized on the interior surface of PSP for the specific recognition of targeting biomacromolecules. The resultant injectable scavengers demonstrate satisfactory performance for sequestering tumor necrosis factor (TNF) or TNF receptor (TNFR) in serum and in vivo. The salient biocompatibility of the preparing scavenger is demonstrated through simulative hemoperfusion experiments and in vivo toxicology tests. Importantly, the scavengers are injected into mice like a drug to rapidly remove blood‐circulating endogenous TNFR. These features together with its facile fabrication present the silicon‐based porous particles as candidates in clinical application for relieving the infection‐induced CSS. |
| first_indexed | 2024-03-11T18:16:26Z |
| format | Article |
| id | doaj.art-a3f6b39f293e40de9af77b1889d19ec8 |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-03-11T18:16:26Z |
| publishDate | 2023-10-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-a3f6b39f293e40de9af77b1889d19ec82023-10-16T07:03:54ZengWiley-VCHAdvanced NanoBiomed Research2699-93072023-10-01310n/an/a10.1002/anbr.202300037Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome TreatmentRuogu Qi0Shengliang Li1Feng Li2Junhua Mai3Yu Wang4Guixian Zhu5Dechen Zhang6Zheng Li7Haifa Shen8Jianliang Shen9Xuewu Liu10School of Medicine & Holistic Integrative Medicine Nanjing University of Chinese Medicine Nanjing 210023 ChinaDepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USADepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USASchool of Ophthalmology & Optometry School of Biomedical Engineering Wenzhou Medical University Wenzhou Zhejiang 325035 ChinaDepartment of Nanomedicine Houston Methodist Research Institute Houston TX 77030 USAScavenging excessively secreted cytokines from plasma is vital for treating cytokine storm syndrome (CSS). Therefore, appropriate adsorbent materials are highly desired for efficient and selectively capturing the plasma cytokines. For this purpose, injectable porous silicon particles (PSPs) are designed as scavenging adsorbents. The fabricated PSP features high porosity for large pore volume and high specific surface area. Polyethylene glycol is coated on the outer surface of PSP for a longer body circulation time, while antibodies are immobilized on the interior surface of PSP for the specific recognition of targeting biomacromolecules. The resultant injectable scavengers demonstrate satisfactory performance for sequestering tumor necrosis factor (TNF) or TNF receptor (TNFR) in serum and in vivo. The salient biocompatibility of the preparing scavenger is demonstrated through simulative hemoperfusion experiments and in vivo toxicology tests. Importantly, the scavengers are injected into mice like a drug to rapidly remove blood‐circulating endogenous TNFR. These features together with its facile fabrication present the silicon‐based porous particles as candidates in clinical application for relieving the infection‐induced CSS.https://doi.org/10.1002/anbr.202300037porous silicon particlesadsorbent materialscytokine scavengercytokine storm syndrome reliefinjectable particles |
| spellingShingle | Ruogu Qi Shengliang Li Feng Li Junhua Mai Yu Wang Guixian Zhu Dechen Zhang Zheng Li Haifa Shen Jianliang Shen Xuewu Liu Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment Advanced NanoBiomed Research porous silicon particles adsorbent materials cytokine scavenger cytokine storm syndrome relief injectable particles |
| title | Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment |
| title_full | Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment |
| title_fullStr | Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment |
| title_full_unstemmed | Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment |
| title_short | Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment |
| title_sort | injectable porous silicon nanoparticles as a plasma cytokine scavenger for potentiating cytokine storm syndrome treatment |
| topic | porous silicon particles adsorbent materials cytokine scavenger cytokine storm syndrome relief injectable particles |
| url | https://doi.org/10.1002/anbr.202300037 |
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