The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference
Abstract Extended CAG trinucleotide repeats (TNR) in the genes huntingtin (HTT) and androgen receptor (AR) are the cause of two progressive neurodegenerative disorders: Huntington’s disease (HD) and Spinal and Bulbar Muscular Atrophy (SBMA), respectively. Anyone who inherits the mutant gene in the c...
Main Authors: | Andrea E. Murmann, Monal Patel, Si-Yeon Jeong, Elizabeth T. Bartom, A. Jennifer Morton, Marcus E. Peter |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2022-12-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-022-05494-1 |
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