Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99.
Genetic recombination is considered to be a very frequent phenomenon among enteroviruses (Family Picornaviridae, Genus Enterovirus). However, the recombination patterns may differ between enterovirus species and between types within species. Enterovirus C (EV-C) species contains 21 types. In the cap...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3983234?pdf=render |
| _version_ | 1819274246416760832 |
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| author | Teemu Smura Soile Blomqvist Tytti Vuorinen Olga Ivanova Elena Samoilovich Haider Al-Hello Carita Savolainen-Kopra Tapani Hovi Merja Roivainen |
| author_facet | Teemu Smura Soile Blomqvist Tytti Vuorinen Olga Ivanova Elena Samoilovich Haider Al-Hello Carita Savolainen-Kopra Tapani Hovi Merja Roivainen |
| author_sort | Teemu Smura |
| collection | DOAJ |
| description | Genetic recombination is considered to be a very frequent phenomenon among enteroviruses (Family Picornaviridae, Genus Enterovirus). However, the recombination patterns may differ between enterovirus species and between types within species. Enterovirus C (EV-C) species contains 21 types. In the capsid coding P1 region, the types of EV-C species cluster further into three sub-groups (designated here as A-C). In this study, the recombination pattern of EV-C species sub-group B that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99 was determined using partial 5'UTR and VP1 sequences of enterovirus strains isolated during poliovirus surveillance and previously published complete genome sequences. Several inter-typic recombination events were detected. Furthermore, the analyses suggested that inter-typic recombination events have occurred mainly within the distinct sub-groups of EV-C species. Only sporadic recombination events between EV-C species sub-group B and other EV-C sub-groups were detected. In addition, strict recombination barriers were inferred for CVA-21 genotype C and CVA-24 variant strains. These results suggest that the frequency of inter-typic recombinations, even within species, may depend on the phylogenetic position of the given viruses. |
| first_indexed | 2024-12-23T23:05:23Z |
| format | Article |
| id | doaj.art-a3f7042b395e4d95a9af54106bd8090a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T23:05:23Z |
| publishDate | 2014-01-01 |
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| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a3f7042b395e4d95a9af54106bd8090a2022-12-21T17:26:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9457910.1371/journal.pone.0094579Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99.Teemu SmuraSoile BlomqvistTytti VuorinenOlga IvanovaElena SamoilovichHaider Al-HelloCarita Savolainen-KopraTapani HoviMerja RoivainenGenetic recombination is considered to be a very frequent phenomenon among enteroviruses (Family Picornaviridae, Genus Enterovirus). However, the recombination patterns may differ between enterovirus species and between types within species. Enterovirus C (EV-C) species contains 21 types. In the capsid coding P1 region, the types of EV-C species cluster further into three sub-groups (designated here as A-C). In this study, the recombination pattern of EV-C species sub-group B that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99 was determined using partial 5'UTR and VP1 sequences of enterovirus strains isolated during poliovirus surveillance and previously published complete genome sequences. Several inter-typic recombination events were detected. Furthermore, the analyses suggested that inter-typic recombination events have occurred mainly within the distinct sub-groups of EV-C species. Only sporadic recombination events between EV-C species sub-group B and other EV-C sub-groups were detected. In addition, strict recombination barriers were inferred for CVA-21 genotype C and CVA-24 variant strains. These results suggest that the frequency of inter-typic recombinations, even within species, may depend on the phylogenetic position of the given viruses.http://europepmc.org/articles/PMC3983234?pdf=render |
| spellingShingle | Teemu Smura Soile Blomqvist Tytti Vuorinen Olga Ivanova Elena Samoilovich Haider Al-Hello Carita Savolainen-Kopra Tapani Hovi Merja Roivainen Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99. PLoS ONE |
| title | Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99. |
| title_full | Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99. |
| title_fullStr | Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99. |
| title_full_unstemmed | Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99. |
| title_short | Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99. |
| title_sort | recombination in the evolution of enterovirus c species sub group that contains types cva 21 cva 24 ev c95 ev c96 and ev c99 |
| url | http://europepmc.org/articles/PMC3983234?pdf=render |
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