The pathogenesis and potential therapeutic targets in sepsis
Abstract Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host systemic inflammatory and immune response to infection.” At present, sepsis continues to pose a grave healthcare concern worldwide. Despite the use of supportive measures in treating traditional sepsis, s...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.418 |
| _version_ | 1827396520096301056 |
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| author | Wendan Zhang Honghong Jiang Gaosong Wu Pengli Huang Haonan Wang Huazhang An Sanhong Liu Weidong Zhang |
| author_facet | Wendan Zhang Honghong Jiang Gaosong Wu Pengli Huang Haonan Wang Huazhang An Sanhong Liu Weidong Zhang |
| author_sort | Wendan Zhang |
| collection | DOAJ |
| description | Abstract Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host systemic inflammatory and immune response to infection.” At present, sepsis continues to pose a grave healthcare concern worldwide. Despite the use of supportive measures in treating traditional sepsis, such as intravenous fluids, vasoactive substances, and oxygen plus antibiotics to eradicate harmful pathogens, there is an ongoing increase in both the morbidity and mortality associated with sepsis during clinical interventions. Therefore, it is urgent to design specific pharmacologic agents for the treatment of sepsis and convert them into a novel targeted treatment strategy. Herein, we provide an overview of the molecular mechanisms that may be involved in sepsis, such as the inflammatory response, immune dysfunction, complement deactivation, mitochondrial damage, and endoplasmic reticulum stress. Additionally, we highlight important targets involved in sepsis‐related regulatory mechanisms, including GSDMD, HMGB1, STING, and SQSTM1, among others. We summarize the latest advancements in potential therapeutic drugs that specifically target these signaling pathways and paramount targets, covering both preclinical studies and clinical trials. In addition, this review provides a detailed description of the crosstalk and function between signaling pathways and vital targets, which provides more opportunities for the clinical development of new treatments for sepsis. |
| first_indexed | 2024-03-08T18:52:15Z |
| format | Article |
| id | doaj.art-a3f8069b00b44c81926d445a17ebb1c9 |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-03-08T18:52:15Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-a3f8069b00b44c81926d445a17ebb1c92023-12-28T16:52:34ZengWileyMedComm2688-26632023-12-0146n/an/a10.1002/mco2.418The pathogenesis and potential therapeutic targets in sepsisWendan Zhang0Honghong Jiang1Gaosong Wu2Pengli Huang3Haonan Wang4Huazhang An5Sanhong Liu6Weidong Zhang7Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai ChinaShanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai ChinaShanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai ChinaShanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai ChinaShanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai ChinaShandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan Shandong ChinaShanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai ChinaShanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai ChinaAbstract Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host systemic inflammatory and immune response to infection.” At present, sepsis continues to pose a grave healthcare concern worldwide. Despite the use of supportive measures in treating traditional sepsis, such as intravenous fluids, vasoactive substances, and oxygen plus antibiotics to eradicate harmful pathogens, there is an ongoing increase in both the morbidity and mortality associated with sepsis during clinical interventions. Therefore, it is urgent to design specific pharmacologic agents for the treatment of sepsis and convert them into a novel targeted treatment strategy. Herein, we provide an overview of the molecular mechanisms that may be involved in sepsis, such as the inflammatory response, immune dysfunction, complement deactivation, mitochondrial damage, and endoplasmic reticulum stress. Additionally, we highlight important targets involved in sepsis‐related regulatory mechanisms, including GSDMD, HMGB1, STING, and SQSTM1, among others. We summarize the latest advancements in potential therapeutic drugs that specifically target these signaling pathways and paramount targets, covering both preclinical studies and clinical trials. In addition, this review provides a detailed description of the crosstalk and function between signaling pathways and vital targets, which provides more opportunities for the clinical development of new treatments for sepsis.https://doi.org/10.1002/mco2.418molecular mechanismpathogenesissepsissignaling pathwaystherapeutic drugs |
| spellingShingle | Wendan Zhang Honghong Jiang Gaosong Wu Pengli Huang Haonan Wang Huazhang An Sanhong Liu Weidong Zhang The pathogenesis and potential therapeutic targets in sepsis MedComm molecular mechanism pathogenesis sepsis signaling pathways therapeutic drugs |
| title | The pathogenesis and potential therapeutic targets in sepsis |
| title_full | The pathogenesis and potential therapeutic targets in sepsis |
| title_fullStr | The pathogenesis and potential therapeutic targets in sepsis |
| title_full_unstemmed | The pathogenesis and potential therapeutic targets in sepsis |
| title_short | The pathogenesis and potential therapeutic targets in sepsis |
| title_sort | pathogenesis and potential therapeutic targets in sepsis |
| topic | molecular mechanism pathogenesis sepsis signaling pathways therapeutic drugs |
| url | https://doi.org/10.1002/mco2.418 |
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