Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC–MS Profiles of Maraviroc
In this study, nine forced degradation products of maraviroc were found using chemometric analysis. This antiretroviral drug was subjected to photolytic, oxidative, as well as neutral, basic and acidic hydrolysis stress conditions. Additionally, its electrochemical transformation on platinum, gold a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/3/1195 |
| _version_ | 1797623779022602240 |
|---|---|
| author | Michał Wroński Jakub Trawiński Łukasz Komsta Robert Skibiński |
| author_facet | Michał Wroński Jakub Trawiński Łukasz Komsta Robert Skibiński |
| author_sort | Michał Wroński |
| collection | DOAJ |
| description | In this study, nine forced degradation products of maraviroc were found using chemometric analysis. This antiretroviral drug was subjected to photolytic, oxidative, as well as neutral, basic and acidic hydrolysis stress conditions. Additionally, its electrochemical transformation on platinum, gold and glassy carbon screen-printed electrodes was examined. This study showed that maraviroc is especially susceptible to UVA, H<sub>2</sub>O<sub>2</sub> and electrochemical degradation, while being resistant to neutral and acidic hydrolysis. A cluster analysis showed that the electrochemical transformation, with particular reference to the platinum electrode, is able to partially simulate the forced degradation processes, especially in the context of redox reactions. These findings indicate that the electrochemical methods can be considered as quick and relatively low-cost supplements to the commonly applied forced degradation procedures. |
| first_indexed | 2024-03-11T09:33:35Z |
| format | Article |
| id | doaj.art-a3f8f833e69b4044935933269fcc8d30 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T09:33:35Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a3f8f833e69b4044935933269fcc8d302023-11-16T17:28:59ZengMDPI AGMolecules1420-30492023-01-01283119510.3390/molecules28031195Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC–MS Profiles of MaravirocMichał Wroński0Jakub Trawiński1Łukasz Komsta2Robert Skibiński3Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, PolandIn this study, nine forced degradation products of maraviroc were found using chemometric analysis. This antiretroviral drug was subjected to photolytic, oxidative, as well as neutral, basic and acidic hydrolysis stress conditions. Additionally, its electrochemical transformation on platinum, gold and glassy carbon screen-printed electrodes was examined. This study showed that maraviroc is especially susceptible to UVA, H<sub>2</sub>O<sub>2</sub> and electrochemical degradation, while being resistant to neutral and acidic hydrolysis. A cluster analysis showed that the electrochemical transformation, with particular reference to the platinum electrode, is able to partially simulate the forced degradation processes, especially in the context of redox reactions. These findings indicate that the electrochemical methods can be considered as quick and relatively low-cost supplements to the commonly applied forced degradation procedures.https://www.mdpi.com/1420-3049/28/3/1195chemometricsQ-TOFmass spectrometryUHPLCphotodegradationdegradation studies |
| spellingShingle | Michał Wroński Jakub Trawiński Łukasz Komsta Robert Skibiński Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC–MS Profiles of Maraviroc Molecules chemometrics Q-TOF mass spectrometry UHPLC photodegradation degradation studies |
| title | Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC–MS Profiles of Maraviroc |
| title_full | Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC–MS Profiles of Maraviroc |
| title_fullStr | Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC–MS Profiles of Maraviroc |
| title_full_unstemmed | Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC–MS Profiles of Maraviroc |
| title_short | Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC–MS Profiles of Maraviroc |
| title_sort | multivariate chemometric comparison of forced degradation and electrochemical oxidation lc ms profiles of maraviroc |
| topic | chemometrics Q-TOF mass spectrometry UHPLC photodegradation degradation studies |
| url | https://www.mdpi.com/1420-3049/28/3/1195 |
| work_keys_str_mv | AT michałwronski multivariatechemometriccomparisonofforceddegradationandelectrochemicaloxidationlcmsprofilesofmaraviroc AT jakubtrawinski multivariatechemometriccomparisonofforceddegradationandelectrochemicaloxidationlcmsprofilesofmaraviroc AT łukaszkomsta multivariatechemometriccomparisonofforceddegradationandelectrochemicaloxidationlcmsprofilesofmaraviroc AT robertskibinski multivariatechemometriccomparisonofforceddegradationandelectrochemicaloxidationlcmsprofilesofmaraviroc |