RESULTS OF THE IMMUNIZATION ACCORDING TO THE NATIONAL CALENDAR ASSOCIATED WITH VACCINATION AGAINST INFLUENZA IN CHILDREN WITH SOMATIC DISORDERS AND IMMUNODEFICIENCY

Aim: to study safety and immunological efficacy of vaccination against influenza in separate and associated immunization according to the National Calendar. Patients and methods: 100 children with various disorders as well as children with HIV subjected to revaccination against diphtheria, tetanus,...

Full description

Bibliographic Details
Main Authors: S. M. Kharit, A. A. Ruleva, O. V. Goleva, O. S. Kalinogorskaya, V. A. Apryatina
Format: Article
Language:English
Published: "Paediatrician" Publishers LLC 2014-01-01
Series:Вопросы современной педиатрии
Subjects:
Online Access:https://vsp.spr-journal.ru/jour/article/view/241
_version_ 1797702854639616000
author S. M. Kharit
A. A. Ruleva
O. V. Goleva
O. S. Kalinogorskaya
V. A. Apryatina
author_facet S. M. Kharit
A. A. Ruleva
O. V. Goleva
O. S. Kalinogorskaya
V. A. Apryatina
author_sort S. M. Kharit
collection DOAJ
description Aim: to study safety and immunological efficacy of vaccination against influenza in separate and associated immunization according to the National Calendar. Patients and methods: 100 children with various disorders as well as children with HIV subjected to revaccination against diphtheria, tetanus, measles, parotiditis and rubella, were included into the study. Children were divided into 5 groups of 20 persons each: groups of separate or associated vaccination. In order to assess safety of vaccination children were observed for 30 days after vaccination. In order to analyze immunologic efficacy participants were taken serum tests before and on the 30th day after vaccination. Results: the study demonstrated high safety of the vaccine against influenza. Mild and moderate topical and general reactions were observed in isolated instances and did not differ in comparison groups. Simultaneous vaccination against influenza with immunization against diphtheria, parotiditis and rubella did not influence synthesis of antibodies, while synthesis of antibodies against measles was decreased; immunization against diphtheria and measles when associated with vaccination against influenza depressed synthesis of antibodies against A/H3N2 influenza. Conclusions: vaccine against influenza has low reactivity, high safety and can be used in association with immunization according to the National calendar in independence to somatic disorders of patients.
first_indexed 2024-03-12T04:56:56Z
format Article
id doaj.art-a3f94beb72f946918f17be7c0f88924e
institution Directory Open Access Journal
issn 1682-5527
1682-5535
language English
last_indexed 2024-03-12T04:56:56Z
publishDate 2014-01-01
publisher "Paediatrician" Publishers LLC
record_format Article
series Вопросы современной педиатрии
spelling doaj.art-a3f94beb72f946918f17be7c0f88924e2023-09-03T09:15:02Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352014-01-0113114815410.15690/vsp.v13i1.926241RESULTS OF THE IMMUNIZATION ACCORDING TO THE NATIONAL CALENDAR ASSOCIATED WITH VACCINATION AGAINST INFLUENZA IN CHILDREN WITH SOMATIC DISORDERS AND IMMUNODEFICIENCYS. M. Kharit0A. A. Ruleva1O. V. Goleva2O. S. Kalinogorskaya3V. A. Apryatina4НИИ детских инфекций, Санкт-Петербург Санкт-Петербургский государственный педиатрический медицинский университетНИИ детских инфекций, Санкт-Петербург Санкт-Петербургский государственный педиатрический медицинский университетНИИ детских инфекций, Санкт-ПетербургНИИ детских инфекций, Санкт-ПетербургГНЦ Институт иммунологии, МоскваAim: to study safety and immunological efficacy of vaccination against influenza in separate and associated immunization according to the National Calendar. Patients and methods: 100 children with various disorders as well as children with HIV subjected to revaccination against diphtheria, tetanus, measles, parotiditis and rubella, were included into the study. Children were divided into 5 groups of 20 persons each: groups of separate or associated vaccination. In order to assess safety of vaccination children were observed for 30 days after vaccination. In order to analyze immunologic efficacy participants were taken serum tests before and on the 30th day after vaccination. Results: the study demonstrated high safety of the vaccine against influenza. Mild and moderate topical and general reactions were observed in isolated instances and did not differ in comparison groups. Simultaneous vaccination against influenza with immunization against diphtheria, parotiditis and rubella did not influence synthesis of antibodies, while synthesis of antibodies against measles was decreased; immunization against diphtheria and measles when associated with vaccination against influenza depressed synthesis of antibodies against A/H3N2 influenza. Conclusions: vaccine against influenza has low reactivity, high safety and can be used in association with immunization according to the National calendar in independence to somatic disorders of patients.https://vsp.spr-journal.ru/jour/article/view/241вакцина против гриппасочетанная вакцинациябезопасностьиммунологическая эффективность
spellingShingle S. M. Kharit
A. A. Ruleva
O. V. Goleva
O. S. Kalinogorskaya
V. A. Apryatina
RESULTS OF THE IMMUNIZATION ACCORDING TO THE NATIONAL CALENDAR ASSOCIATED WITH VACCINATION AGAINST INFLUENZA IN CHILDREN WITH SOMATIC DISORDERS AND IMMUNODEFICIENCY
Вопросы современной педиатрии
вакцина против гриппа
сочетанная вакцинация
безопасность
иммунологическая эффективность
title RESULTS OF THE IMMUNIZATION ACCORDING TO THE NATIONAL CALENDAR ASSOCIATED WITH VACCINATION AGAINST INFLUENZA IN CHILDREN WITH SOMATIC DISORDERS AND IMMUNODEFICIENCY
title_full RESULTS OF THE IMMUNIZATION ACCORDING TO THE NATIONAL CALENDAR ASSOCIATED WITH VACCINATION AGAINST INFLUENZA IN CHILDREN WITH SOMATIC DISORDERS AND IMMUNODEFICIENCY
title_fullStr RESULTS OF THE IMMUNIZATION ACCORDING TO THE NATIONAL CALENDAR ASSOCIATED WITH VACCINATION AGAINST INFLUENZA IN CHILDREN WITH SOMATIC DISORDERS AND IMMUNODEFICIENCY
title_full_unstemmed RESULTS OF THE IMMUNIZATION ACCORDING TO THE NATIONAL CALENDAR ASSOCIATED WITH VACCINATION AGAINST INFLUENZA IN CHILDREN WITH SOMATIC DISORDERS AND IMMUNODEFICIENCY
title_short RESULTS OF THE IMMUNIZATION ACCORDING TO THE NATIONAL CALENDAR ASSOCIATED WITH VACCINATION AGAINST INFLUENZA IN CHILDREN WITH SOMATIC DISORDERS AND IMMUNODEFICIENCY
title_sort results of the immunization according to the national calendar associated with vaccination against influenza in children with somatic disorders and immunodeficiency
topic вакцина против гриппа
сочетанная вакцинация
безопасность
иммунологическая эффективность
url https://vsp.spr-journal.ru/jour/article/view/241
work_keys_str_mv AT smkharit resultsoftheimmunizationaccordingtothenationalcalendarassociatedwithvaccinationagainstinfluenzainchildrenwithsomaticdisordersandimmunodeficiency
AT aaruleva resultsoftheimmunizationaccordingtothenationalcalendarassociatedwithvaccinationagainstinfluenzainchildrenwithsomaticdisordersandimmunodeficiency
AT ovgoleva resultsoftheimmunizationaccordingtothenationalcalendarassociatedwithvaccinationagainstinfluenzainchildrenwithsomaticdisordersandimmunodeficiency
AT oskalinogorskaya resultsoftheimmunizationaccordingtothenationalcalendarassociatedwithvaccinationagainstinfluenzainchildrenwithsomaticdisordersandimmunodeficiency
AT vaapryatina resultsoftheimmunizationaccordingtothenationalcalendarassociatedwithvaccinationagainstinfluenzainchildrenwithsomaticdisordersandimmunodeficiency