TCA and SSRI Antidepressants Exert Selection Pressure for Efflux-Dependent Antibiotic Resistance Mechanisms in Escherichia coli

TCA and SSRI Antidepressants Exert Selection Pressure for Efflux-Dependent Antibiotic Resistance Mechanisms in Escherichia coli

ABSTRACT Microbial diversity is reduced in the gut microbiota of animals and humans treated with selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs). The mechanisms driving the changes in microbial composition, while largely unknown, is critical to understand conside...

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Bibliographic Details
Main Authors: Jin Ou, Paul Elizalde, Hao-Bo Guo, Hong Qin, Brian T.D. Tobe, John S. Choy
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
E. coli
SSRI
TCA
antibiotics
antidepressants
drug resistance mechanisms
Online Access:https://journals.asm.org/doi/10.1128/mbio.02191-22

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