Acanthus leucostachyus leaf extracts promote excision wound healing in mice
Objective: To evaluate the in vivo wound healing activity of Acanthus leucostachyus leaf extracts using an excision wound model in mice. Methods: Mice were divided into two groups of six animals in each group: the control group and the Acanthus leucostachyus extract-treated group. Healing potential...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=11;spage=475;epage=482;aulast=Dev |
| _version_ | 1811177767449919488 |
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| author | Deepjyoti Dev Ashish Sarkar Bishnupada Roy |
| author_facet | Deepjyoti Dev Ashish Sarkar Bishnupada Roy |
| author_sort | Deepjyoti Dev |
| collection | DOAJ |
| description | Objective: To evaluate the in vivo wound healing activity of Acanthus leucostachyus leaf extracts using an excision wound model in mice.
Methods: Mice were divided into two groups of six animals in each group: the control group and the Acanthus leucostachyus extract-treated group. Healing potential was evaluated by determination of physical parameters (contraction rate, epithelialization period, and tensile strength), biochemical parameters (protein, DNA, and hydroxyproline content), the expression of growth factor and proinflammatory cytokines, as well as histological and ultrastructural observations.
Results: Treatment with Acanthus leucostachyus leaf extracts markedly increased the rate of wound contraction, tensile strength, the concentrations of protein, DNA, and hydroxyproline, and the expression of growth factor, as well as promoted epithelialization, compared to the control. In addition, Acanthus leucostachyus leaf extracts significantly reduced the expression of pro-inflammatory cytokines. Histological and ultrastructural studies revealed the presence of thicker epithelial layer and smoother surface topography in the extract-treated group compared to the control.
Conclusions: Acanthus leucostachyus leaf extracts show potent wound-healing activity and can be used as a wound healing agent. |
| first_indexed | 2024-04-11T06:06:40Z |
| format | Article |
| id | doaj.art-a3fcdae54bf14e988560fcc9f9bd52f7 |
| institution | Directory Open Access Journal |
| issn | 2221-1691 2588-9222 |
| language | English |
| last_indexed | 2024-04-11T06:06:40Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-a3fcdae54bf14e988560fcc9f9bd52f72022-12-22T04:41:28ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912588-92222022-01-01121147548210.4103/2221-1691.360563Acanthus leucostachyus leaf extracts promote excision wound healing in miceDeepjyoti DevAshish SarkarBishnupada RoyObjective: To evaluate the in vivo wound healing activity of Acanthus leucostachyus leaf extracts using an excision wound model in mice. Methods: Mice were divided into two groups of six animals in each group: the control group and the Acanthus leucostachyus extract-treated group. Healing potential was evaluated by determination of physical parameters (contraction rate, epithelialization period, and tensile strength), biochemical parameters (protein, DNA, and hydroxyproline content), the expression of growth factor and proinflammatory cytokines, as well as histological and ultrastructural observations. Results: Treatment with Acanthus leucostachyus leaf extracts markedly increased the rate of wound contraction, tensile strength, the concentrations of protein, DNA, and hydroxyproline, and the expression of growth factor, as well as promoted epithelialization, compared to the control. In addition, Acanthus leucostachyus leaf extracts significantly reduced the expression of pro-inflammatory cytokines. Histological and ultrastructural studies revealed the presence of thicker epithelial layer and smoother surface topography in the extract-treated group compared to the control. Conclusions: Acanthus leucostachyus leaf extracts show potent wound-healing activity and can be used as a wound healing agent.http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=11;spage=475;epage=482;aulast=Devchronic wounds; acanthus leucostachyus; epithelialization period; tensile strength; hydroxyproline; proinflammatory cytokine; wound healing |
| spellingShingle | Deepjyoti Dev Ashish Sarkar Bishnupada Roy Acanthus leucostachyus leaf extracts promote excision wound healing in mice Asian Pacific Journal of Tropical Biomedicine chronic wounds; acanthus leucostachyus; epithelialization period; tensile strength; hydroxyproline; proinflammatory cytokine; wound healing |
| title | Acanthus leucostachyus leaf extracts promote excision wound healing in mice |
| title_full | Acanthus leucostachyus leaf extracts promote excision wound healing in mice |
| title_fullStr | Acanthus leucostachyus leaf extracts promote excision wound healing in mice |
| title_full_unstemmed | Acanthus leucostachyus leaf extracts promote excision wound healing in mice |
| title_short | Acanthus leucostachyus leaf extracts promote excision wound healing in mice |
| title_sort | acanthus leucostachyus leaf extracts promote excision wound healing in mice |
| topic | chronic wounds; acanthus leucostachyus; epithelialization period; tensile strength; hydroxyproline; proinflammatory cytokine; wound healing |
| url | http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=11;spage=475;epage=482;aulast=Dev |
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