Serum Cystatin C in Patients with Delayed Graft Function
Despite recent studies showing that serum Cystatin C (CysC) is a better marker for glomerular filtration rate (GFR) than the ubiquitously used creatinine, the clinical utility of these findings remains to be evaluated. This marker is very sensitive for allograft function after renal transplantation....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-03-01
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| Series: | Acta Medica Bulgarica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/amb-2016-0002 |
| _version_ | 1818401303334748160 |
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| author | Boncheva M. Gruev T. Nikolov G. |
| author_facet | Boncheva M. Gruev T. Nikolov G. |
| author_sort | Boncheva M. |
| collection | DOAJ |
| description | Despite recent studies showing that serum Cystatin C (CysC) is a better marker for glomerular filtration rate (GFR) than the ubiquitously used creatinine, the clinical utility of these findings remains to be evaluated. This marker is very sensitive for allograft function after renal transplantation. The concentration of CysC was compared with that of the creatinine. Decreased renal function was followed in 64 transplanted patients. Serum CysC significantly correlated with creatinine in healthy controls (r = 0.625, p < 0.0001), whereas in the transplanted patients the mean serum creatinine and CysC concentrations were: 81 ± 13 mmol/L and 0.90 ± 0.22 mg/L, respectively. Serum CysC and creatinine significantly correlated throughout the post transplantation period (r = 0.686, p < 0.001), but we confirmed differences between kinetics of these parameters. In the first four days after transplantation the CysC concentration was normalized faster than the creatinine concentration. Development of acute rejection episode (between 5 and 7 days) showed high sensitivity and specificity of the changes of CysC compared with those of creatinine. |
| first_indexed | 2024-12-14T07:50:19Z |
| format | Article |
| id | doaj.art-a3fe18d0903b4baf989b5cd0e5dc6aef |
| institution | Directory Open Access Journal |
| issn | 0324-1750 |
| language | English |
| last_indexed | 2024-12-14T07:50:19Z |
| publishDate | 2016-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Medica Bulgarica |
| spelling | doaj.art-a3fe18d0903b4baf989b5cd0e5dc6aef2022-12-21T23:10:44ZengSciendoActa Medica Bulgarica0324-17502016-03-01431142210.1515/amb-2016-0002amb-2016-0002Serum Cystatin C in Patients with Delayed Graft FunctionBoncheva M.0Gruev T.1Nikolov G.2Medical University of Varna, BulgariaDepartment of Nephrology, Institute of Clinical Biochemistry, University Clinical Center, Skopje, Macedonia, Vodnjanska str.17 1000 Skopje, Macedonia tel. ++389 2 119 080++ 389 2 112 539Medical University of Varna, BulgariaDespite recent studies showing that serum Cystatin C (CysC) is a better marker for glomerular filtration rate (GFR) than the ubiquitously used creatinine, the clinical utility of these findings remains to be evaluated. This marker is very sensitive for allograft function after renal transplantation. The concentration of CysC was compared with that of the creatinine. Decreased renal function was followed in 64 transplanted patients. Serum CysC significantly correlated with creatinine in healthy controls (r = 0.625, p < 0.0001), whereas in the transplanted patients the mean serum creatinine and CysC concentrations were: 81 ± 13 mmol/L and 0.90 ± 0.22 mg/L, respectively. Serum CysC and creatinine significantly correlated throughout the post transplantation period (r = 0.686, p < 0.001), but we confirmed differences between kinetics of these parameters. In the first four days after transplantation the CysC concentration was normalized faster than the creatinine concentration. Development of acute rejection episode (between 5 and 7 days) showed high sensitivity and specificity of the changes of CysC compared with those of creatinine.https://doi.org/10.1515/amb-2016-0002renal transplantationdelayed graft functioncystatin c |
| spellingShingle | Boncheva M. Gruev T. Nikolov G. Serum Cystatin C in Patients with Delayed Graft Function Acta Medica Bulgarica renal transplantation delayed graft function cystatin c |
| title | Serum Cystatin C in Patients with Delayed Graft Function |
| title_full | Serum Cystatin C in Patients with Delayed Graft Function |
| title_fullStr | Serum Cystatin C in Patients with Delayed Graft Function |
| title_full_unstemmed | Serum Cystatin C in Patients with Delayed Graft Function |
| title_short | Serum Cystatin C in Patients with Delayed Graft Function |
| title_sort | serum cystatin c in patients with delayed graft function |
| topic | renal transplantation delayed graft function cystatin c |
| url | https://doi.org/10.1515/amb-2016-0002 |
| work_keys_str_mv | AT bonchevam serumcystatincinpatientswithdelayedgraftfunction AT gruevt serumcystatincinpatientswithdelayedgraftfunction AT nikolovg serumcystatincinpatientswithdelayedgraftfunction |