Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country results
Purpose: The aim of this study was to evaluate the demographic characteristics, clinical and pathological factors, and the outcome of cancer and COVID-19 patients in Mexico. Patients and methods: A prospective, multicentric study was performed through a digital platform to have a national registry o...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-09-01
|
| Series: | Therapeutic Advances in Chronic Disease |
| Online Access: | https://doi.org/10.1177/20406223211047755 |
| _version_ | 1818654780026781696 |
|---|---|
| author | Erika Ruiz-Garcia Adriana Peña-Nieves Jorge Alegria-Baños Patricia Cornejo-Juarez Abelardo Meneses-García Samuel Rivera Rivera Juan José Sánchez Raquel Gerson-Cwilich Daniela Shveid Gerson Heriberto Medina Franco Gabriela Alejandra Buerba Alicia Acosta Espinoza Norma Valencia Mijares Edith A. Fernández-Figueroa Roberto A. Vázquez Diana Vilar-Compte |
| author_facet | Erika Ruiz-Garcia Adriana Peña-Nieves Jorge Alegria-Baños Patricia Cornejo-Juarez Abelardo Meneses-García Samuel Rivera Rivera Juan José Sánchez Raquel Gerson-Cwilich Daniela Shveid Gerson Heriberto Medina Franco Gabriela Alejandra Buerba Alicia Acosta Espinoza Norma Valencia Mijares Edith A. Fernández-Figueroa Roberto A. Vázquez Diana Vilar-Compte |
| author_sort | Erika Ruiz-Garcia |
| collection | DOAJ |
| description | Purpose: The aim of this study was to evaluate the demographic characteristics, clinical and pathological factors, and the outcome of cancer and COVID-19 patients in Mexico. Patients and methods: A prospective, multicentric study was performed through a digital platform to have a national registry of patients with cancer and positive SARS-CoV-2 test results through reverse transcription quantitative polymerase chain reaction (RT-qPCR). We performed the analysis through a multivariate logistic regression model and Cox proportional hazard model. Results: From May to December 2020, 599 patients were registered with an average age of 56 years with 59.3% female; 27.2% had hypertension. The most frequent diagnoses were breast cancer (30.4%), lymphoma (14.7%), and colorectal cancer (14.0%); 72.1% of patients had active cancer and 23.5% of patients (141/599) were deceased, the majority of which were men (51.7%). This study found that the prognostic factors that reduced the odds of death were gender (OR = 0.42, p = 0.031) and oxygen saturation (OR = 0.90, p = 0.0001); meanwhile, poor ECOG (OR = 5.4, p = 0.0001), active disease (OR = 3.9, p = 0.041), dyspnea (OR = 2.5, p = 0.027), and nausea (OR = 4.0, p = 0.028) increased the odds of death. In the meantime, the factors that reduce survival time were age (HR = 1.36, p = 0.035), COPD (HR = 8.30, p = 0.004), having palliative treatment (HR = 10.70, p = 0.002), and active cancer without treatment (HR = 8.68, p = 0.008). Conclusion: Mortality in cancer patients with COVID-19 is determined by prognostic factors whose identification is necessary. In our cancer population, we have observed that being female, younger, non-COPD, with non-active cancer, good performance status, and high oxygen levels reduce the probability of death. |
| first_indexed | 2024-12-17T02:59:14Z |
| format | Article |
| id | doaj.art-a3fe4e28761f4e47b96c52bd9c509f1b |
| institution | Directory Open Access Journal |
| issn | 2040-6231 |
| language | English |
| last_indexed | 2024-12-17T02:59:14Z |
| publishDate | 2021-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Chronic Disease |
| spelling | doaj.art-a3fe4e28761f4e47b96c52bd9c509f1b2022-12-21T22:06:09ZengSAGE PublishingTherapeutic Advances in Chronic Disease2040-62312021-09-011210.1177/20406223211047755Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country resultsErika Ruiz-GarciaAdriana Peña-NievesJorge Alegria-BañosPatricia Cornejo-JuarezAbelardo Meneses-GarcíaSamuel Rivera RiveraJuan José SánchezRaquel Gerson-CwilichDaniela Shveid GersonHeriberto Medina FrancoGabriela Alejandra BuerbaAlicia Acosta EspinozaNorma Valencia MijaresEdith A. Fernández-FigueroaRoberto A. VázquezDiana Vilar-ComptePurpose: The aim of this study was to evaluate the demographic characteristics, clinical and pathological factors, and the outcome of cancer and COVID-19 patients in Mexico. Patients and methods: A prospective, multicentric study was performed through a digital platform to have a national registry of patients with cancer and positive SARS-CoV-2 test results through reverse transcription quantitative polymerase chain reaction (RT-qPCR). We performed the analysis through a multivariate logistic regression model and Cox proportional hazard model. Results: From May to December 2020, 599 patients were registered with an average age of 56 years with 59.3% female; 27.2% had hypertension. The most frequent diagnoses were breast cancer (30.4%), lymphoma (14.7%), and colorectal cancer (14.0%); 72.1% of patients had active cancer and 23.5% of patients (141/599) were deceased, the majority of which were men (51.7%). This study found that the prognostic factors that reduced the odds of death were gender (OR = 0.42, p = 0.031) and oxygen saturation (OR = 0.90, p = 0.0001); meanwhile, poor ECOG (OR = 5.4, p = 0.0001), active disease (OR = 3.9, p = 0.041), dyspnea (OR = 2.5, p = 0.027), and nausea (OR = 4.0, p = 0.028) increased the odds of death. In the meantime, the factors that reduce survival time were age (HR = 1.36, p = 0.035), COPD (HR = 8.30, p = 0.004), having palliative treatment (HR = 10.70, p = 0.002), and active cancer without treatment (HR = 8.68, p = 0.008). Conclusion: Mortality in cancer patients with COVID-19 is determined by prognostic factors whose identification is necessary. In our cancer population, we have observed that being female, younger, non-COPD, with non-active cancer, good performance status, and high oxygen levels reduce the probability of death.https://doi.org/10.1177/20406223211047755 |
| spellingShingle | Erika Ruiz-Garcia Adriana Peña-Nieves Jorge Alegria-Baños Patricia Cornejo-Juarez Abelardo Meneses-García Samuel Rivera Rivera Juan José Sánchez Raquel Gerson-Cwilich Daniela Shveid Gerson Heriberto Medina Franco Gabriela Alejandra Buerba Alicia Acosta Espinoza Norma Valencia Mijares Edith A. Fernández-Figueroa Roberto A. Vázquez Diana Vilar-Compte Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country results Therapeutic Advances in Chronic Disease |
| title | Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country results |
| title_full | Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country results |
| title_fullStr | Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country results |
| title_full_unstemmed | Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country results |
| title_short | Prognostic factors in cancer patients infected with SARS-CoV-2: a Latin American country results |
| title_sort | prognostic factors in cancer patients infected with sars cov 2 a latin american country results |
| url | https://doi.org/10.1177/20406223211047755 |
| work_keys_str_mv | AT erikaruizgarcia prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT adrianapenanieves prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT jorgealegriabanos prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT patriciacornejojuarez prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT abelardomenesesgarcia prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT samuelriverarivera prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT juanjosesanchez prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT raquelgersoncwilich prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT danielashveidgerson prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT heribertomedinafranco prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT gabrielaalejandrabuerba prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT aliciaacostaespinoza prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT normavalenciamijares prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT edithafernandezfigueroa prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT robertoavazquez prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults AT dianavilarcompte prognosticfactorsincancerpatientsinfectedwithsarscov2alatinamericancountryresults |