Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration
Chronic low back pain is a critical health problem and a leading cause of disability in aging populations. A major cause of low back pain is considered to be the degeneration of the intervertebral disc (IVD). Recent advances in therapeutics, particularly cell and tissue engineering, offer potential...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2018-05-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2018-0003 |
| _version_ | 1819016102641926144 |
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| author | Kennon Justin C. Awad Mohamed E. Chutkan Norman DeVine John Fulzele Sadanand |
| author_facet | Kennon Justin C. Awad Mohamed E. Chutkan Norman DeVine John Fulzele Sadanand |
| author_sort | Kennon Justin C. |
| collection | DOAJ |
| description | Chronic low back pain is a critical health problem and a leading cause of disability in aging populations. A major cause of low back pain is considered to be the degeneration of the intervertebral disc (IVD). Recent advances in therapeutics, particularly cell and tissue engineering, offer potential methods for inhibiting or reversing IVD degeneration, which have previously been impossible. The use of growth factors is under serious consideration as a potential therapy to enhance IVD tissue regeneration. We reviewed the role of chosen prototypical growth factors and growth factor combinations that have the capacity to improve IVD restoration. A number of growth factors have demonstrated potential to modulate the anabolic and anticatabolic effects in both in vitro and animal studies of IVD tissue engineering. Members of the transforming growth factor-β superfamily, IGF-1, GDF-5, BMP-2, BMP-7, and platelet-derived growth factor have all been investigated as possible therapeutic options for IVD regeneration. The role of growth factors in IVD tissue engineering appears promising; however, further extensive research is needed at both basic science and clinical levels before its application is appropriate for clinical use. |
| first_indexed | 2024-12-21T02:42:18Z |
| format | Article |
| id | doaj.art-a3feeb50cd4445f8833079e82449c014 |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-21T02:42:18Z |
| publishDate | 2018-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-a3feeb50cd4445f8833079e82449c0142022-12-21T19:18:39ZengDe GruyterBiomolecular Concepts1868-50211868-503X2018-05-0191435210.1515/bmc-2018-0003bmc-2018-0003Current insights on use of growth factors as therapy for Intervertebral Disc DegenerationKennon Justin C.0Awad Mohamed E.1Chutkan Norman2DeVine John3Fulzele Sadanand4Department of Orthopaedic Surgery, Augusta University, Augusta, GA, USADepartment of Oral Biology, Augusta University, Augusta, GA, USABanner University Medical Center, University of Arizona College of Medicine – Phoenix, The CORE Institute, Phoenix, AZ, USADepartment of Orthopaedic Surgery, Augusta University, Augusta, GA, USADepartment of Orthopaedic Surgery, Augusta University, Augusta, GA, USAChronic low back pain is a critical health problem and a leading cause of disability in aging populations. A major cause of low back pain is considered to be the degeneration of the intervertebral disc (IVD). Recent advances in therapeutics, particularly cell and tissue engineering, offer potential methods for inhibiting or reversing IVD degeneration, which have previously been impossible. The use of growth factors is under serious consideration as a potential therapy to enhance IVD tissue regeneration. We reviewed the role of chosen prototypical growth factors and growth factor combinations that have the capacity to improve IVD restoration. A number of growth factors have demonstrated potential to modulate the anabolic and anticatabolic effects in both in vitro and animal studies of IVD tissue engineering. Members of the transforming growth factor-β superfamily, IGF-1, GDF-5, BMP-2, BMP-7, and platelet-derived growth factor have all been investigated as possible therapeutic options for IVD regeneration. The role of growth factors in IVD tissue engineering appears promising; however, further extensive research is needed at both basic science and clinical levels before its application is appropriate for clinical use.https://doi.org/10.1515/bmc-2018-0003growth factorintervertebral disctissue engineeringintervertebral disc disease |
| spellingShingle | Kennon Justin C. Awad Mohamed E. Chutkan Norman DeVine John Fulzele Sadanand Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration Biomolecular Concepts growth factor intervertebral disc tissue engineering intervertebral disc disease |
| title | Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration |
| title_full | Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration |
| title_fullStr | Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration |
| title_full_unstemmed | Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration |
| title_short | Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration |
| title_sort | current insights on use of growth factors as therapy for intervertebral disc degeneration |
| topic | growth factor intervertebral disc tissue engineering intervertebral disc disease |
| url | https://doi.org/10.1515/bmc-2018-0003 |
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