Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms
We have previously reported that heated powder mixtures of ibuprofen (IBU) and high surface area nanocellulose exhibit an enhanced dissolution and solubility of the drug due to IBU amorphization. The goal of the present work was to further elaborate the concept and conduct side-by-side in vitro drug...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/1/71 |
| _version_ | 1811183813987926016 |
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| author | Athanasios Mantas Marie-Amélie Petit Albert Mihranyan |
| author_facet | Athanasios Mantas Marie-Amélie Petit Albert Mihranyan |
| author_sort | Athanasios Mantas |
| collection | DOAJ |
| description | We have previously reported that heated powder mixtures of ibuprofen (IBU) and high surface area nanocellulose exhibit an enhanced dissolution and solubility of the drug due to IBU amorphization. The goal of the present work was to further elaborate the concept and conduct side-by-side in vitro drug release comparisons with commercial formulations, including film-coated tablets, soft gel liquid capsules, and IBU-lysine conjugate tablets, in biorelevant media. Directly compressed tablets were produced from heated mixtures of 20% <i>w</i>/<i>w</i> IBU and high surface area Cladophora cellulose (CLAD), with 5% <i>w</i>/<i>w</i> sodium croscarmelose (AcDiSol) as superdisintegrant. The side-by side studies in simulated gastric fluid, fasted-state simulated intestinal fluid, and fed-state simulated intestinal fluid corroborate that the IBU-CLAD tablets show more rapid and less variable release in various media compared to three commercial IBU formulations. On the sidelines of the main work, a possibility of the presence of a new meta-crystalline form of IBU in mixture with nanocellulose is discussed. |
| first_indexed | 2024-04-11T13:04:00Z |
| format | Article |
| id | doaj.art-a3ff2e68dd58418d8539e49a7a19abd8 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T13:04:00Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a3ff2e68dd58418d8539e49a7a19abd82022-12-22T04:22:51ZengMDPI AGPharmaceutics1999-49232020-01-011217110.3390/pharmaceutics12010071pharmaceutics12010071Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage FormsAthanasios Mantas0Marie-Amélie Petit1Albert Mihranyan2Nanotechnology and Functional Materials, Department of Materials Science and Engineering, Box 534 Uppsala University, 75121 Uppsala, SwedenNanotechnology and Functional Materials, Department of Materials Science and Engineering, Box 534 Uppsala University, 75121 Uppsala, SwedenNanotechnology and Functional Materials, Department of Materials Science and Engineering, Box 534 Uppsala University, 75121 Uppsala, SwedenWe have previously reported that heated powder mixtures of ibuprofen (IBU) and high surface area nanocellulose exhibit an enhanced dissolution and solubility of the drug due to IBU amorphization. The goal of the present work was to further elaborate the concept and conduct side-by-side in vitro drug release comparisons with commercial formulations, including film-coated tablets, soft gel liquid capsules, and IBU-lysine conjugate tablets, in biorelevant media. Directly compressed tablets were produced from heated mixtures of 20% <i>w</i>/<i>w</i> IBU and high surface area Cladophora cellulose (CLAD), with 5% <i>w</i>/<i>w</i> sodium croscarmelose (AcDiSol) as superdisintegrant. The side-by side studies in simulated gastric fluid, fasted-state simulated intestinal fluid, and fed-state simulated intestinal fluid corroborate that the IBU-CLAD tablets show more rapid and less variable release in various media compared to three commercial IBU formulations. On the sidelines of the main work, a possibility of the presence of a new meta-crystalline form of IBU in mixture with nanocellulose is discussed.https://www.mdpi.com/1999-4923/12/1/71ibuprofencladophora cellulosebiorelevant mediaamorphouspolymorphsformulation |
| spellingShingle | Athanasios Mantas Marie-Amélie Petit Albert Mihranyan Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms Pharmaceutics ibuprofen cladophora cellulose biorelevant media amorphous polymorphs formulation |
| title | Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms |
| title_full | Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms |
| title_fullStr | Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms |
| title_full_unstemmed | Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms |
| title_short | Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms |
| title_sort | directly compressed tablets of free acid ibuprofen with nanocellulose featuring enhanced dissolution a side by side comparison with commercial oral dosage forms |
| topic | ibuprofen cladophora cellulose biorelevant media amorphous polymorphs formulation |
| url | https://www.mdpi.com/1999-4923/12/1/71 |
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