Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy
The development of biomimetic nanoparticles with functionalities of natural biomaterial remains a major challenge in cancer combination therapy. Herein, we developed a tumor-cell-derived exosome-camouflaged porous silicon nanoparticles (E-MSNs) as a drug delivery system for co-loading ICG and DOX (I...
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| Format: | Article |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.01010/full |
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| author | Ran Tian Ran Tian Ran Tian Zhaosong Wang Ruifang Niu Hanjie Wang Hanjie Wang Weijiang Guan Jin Chang Jin Chang |
| author_facet | Ran Tian Ran Tian Ran Tian Zhaosong Wang Ruifang Niu Hanjie Wang Hanjie Wang Weijiang Guan Jin Chang Jin Chang |
| author_sort | Ran Tian |
| collection | DOAJ |
| description | The development of biomimetic nanoparticles with functionalities of natural biomaterial remains a major challenge in cancer combination therapy. Herein, we developed a tumor-cell-derived exosome-camouflaged porous silicon nanoparticles (E-MSNs) as a drug delivery system for co-loading ICG and DOX (ID@E-MSNs), achieving the synergistic effects of chemotherapy and photothermal therapy against breast cancer. Compared with ID@MSNs, the biomimetic nanoparticles ID@E-MSNs can be effectively taken up by the tumor cell and enhance tumor accumulation with the help of the exosome membrane. ID@E-MSNs also retain the photothermal effect of ICG and cytotoxicity of DOX. Under 808 nm near infrared irradiation, ICG can produce hyperthermia to collapse E-MSNs nanovehicles, accelerate drug release, and induce tumor ablation, achieving effective chemo-photothermal therapy. In vivo results of 4T1 tumor-bearing BALB/c mice showed that ID@E-MSNs could accumulate tumor tissue and inhibit the growth and metastasis of tumor. Thus, tumor exosome-biomimetic nanoparticles indicate a proof-of-concept as a promising drug delivery system for efficient cancer combination therapy. |
| first_indexed | 2024-12-12T13:50:16Z |
| format | Article |
| id | doaj.art-a4050ade9a4b4360ba89d0ca1f548a03 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T13:50:16Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-a4050ade9a4b4360ba89d0ca1f548a032022-12-22T00:22:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-08-01810.3389/fbioe.2020.01010577951Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal TherapyRan Tian0Ran Tian1Ran Tian2Zhaosong Wang3Ruifang Niu4Hanjie Wang5Hanjie Wang6Weijiang Guan7Jin Chang8Jin Chang9School of Life Sciences, Tianjin University, Tianjin, ChinaTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin, ChinaPublic Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, ChinaPublic Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, ChinaPublic Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, ChinaSchool of Life Sciences, Tianjin University, Tianjin, ChinaTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin, ChinaState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, ChinaSchool of Life Sciences, Tianjin University, Tianjin, ChinaTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin, ChinaThe development of biomimetic nanoparticles with functionalities of natural biomaterial remains a major challenge in cancer combination therapy. Herein, we developed a tumor-cell-derived exosome-camouflaged porous silicon nanoparticles (E-MSNs) as a drug delivery system for co-loading ICG and DOX (ID@E-MSNs), achieving the synergistic effects of chemotherapy and photothermal therapy against breast cancer. Compared with ID@MSNs, the biomimetic nanoparticles ID@E-MSNs can be effectively taken up by the tumor cell and enhance tumor accumulation with the help of the exosome membrane. ID@E-MSNs also retain the photothermal effect of ICG and cytotoxicity of DOX. Under 808 nm near infrared irradiation, ICG can produce hyperthermia to collapse E-MSNs nanovehicles, accelerate drug release, and induce tumor ablation, achieving effective chemo-photothermal therapy. In vivo results of 4T1 tumor-bearing BALB/c mice showed that ID@E-MSNs could accumulate tumor tissue and inhibit the growth and metastasis of tumor. Thus, tumor exosome-biomimetic nanoparticles indicate a proof-of-concept as a promising drug delivery system for efficient cancer combination therapy.https://www.frontiersin.org/article/10.3389/fbioe.2020.01010/fulltumor exosomebiomimeticnanovehiclesbreast cancercombination therapy |
| spellingShingle | Ran Tian Ran Tian Ran Tian Zhaosong Wang Ruifang Niu Hanjie Wang Hanjie Wang Weijiang Guan Jin Chang Jin Chang Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy Frontiers in Bioengineering and Biotechnology tumor exosome biomimetic nanovehicles breast cancer combination therapy |
| title | Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy |
| title_full | Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy |
| title_fullStr | Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy |
| title_full_unstemmed | Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy |
| title_short | Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy |
| title_sort | tumor exosome mimicking nanoparticles for tumor combinatorial chemo photothermal therapy |
| topic | tumor exosome biomimetic nanovehicles breast cancer combination therapy |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2020.01010/full |
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