A computerized stroop test for the evaluation of psychotropic drugs in healthy participants
Background: The Stroop paradigm evaluates susceptibility to interference and is sensitive to dysfunction in frontal lobes and drug effects. The aim of the present study was to establish a simple and reliable computerized version of Stroop color-word test, which can be used for screening of various p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-01-01
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| Series: | Indian Journal of Psychological Medicine |
| Subjects: | |
| Online Access: | http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=2;spage=180;epage=189;aulast=Pilli |
| _version_ | 1819018874537902080 |
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| author | Raveendranadh Pilli MUR Naidu Usha Rani Pingali J C Shobha A Praveen Reddy |
| author_facet | Raveendranadh Pilli MUR Naidu Usha Rani Pingali J C Shobha A Praveen Reddy |
| author_sort | Raveendranadh Pilli |
| collection | DOAJ |
| description | Background: The Stroop paradigm evaluates susceptibility to interference and is sensitive to dysfunction in frontal lobes and drug effects. The aim of the present study was to establish a simple and reliable computerized version of Stroop color-word test, which can be used for screening of various psychotropic drugs. Materials and Methods: The standardized method was followed in all cases, by recording the reaction time (RT) in msec in 24 healthy participants using computerized version of Stroop color-word test. Reproducibility of the test procedure was evaluated by recording the RTs by a single experimenter on two sessions (interday reproducibility). Validity of the model was further tested by evaluating the psychotropic effect of Zolpidem 5 mg, Caffeine 500 mg, or Placebo on 24 healthy subjects in a randomized, double blind three-way crossover design. Results: The method was found to produce low variability with coefficient of variation less than 10%. Interday reproducibility was very good as shown by Bland-Altman plot with most of the values within ±2SD. There was a significant increase in RTs in Stroop performance with Zolpidem at 1 hr and 2 hrs; in contrast, caffeine significantly decreased RTs in Stroop performance at 1 hr only compared to placebo. Conclusion: The Stroop color-word recording and analysis system is simple, sensitive to centrally acting drug effects, and has potential for future experimental psychomotor assessment studies. |
| first_indexed | 2024-12-21T03:26:21Z |
| format | Article |
| id | doaj.art-a40635b1ba9d481da14d8ddf3100a90a |
| institution | Directory Open Access Journal |
| issn | 0253-7176 |
| language | English |
| last_indexed | 2024-12-21T03:26:21Z |
| publishDate | 2013-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Psychological Medicine |
| spelling | doaj.art-a40635b1ba9d481da14d8ddf3100a90a2022-12-21T19:17:35ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762013-01-0135218018910.4103/0253-7176.116251A computerized stroop test for the evaluation of psychotropic drugs in healthy participantsRaveendranadh PilliMUR NaiduUsha Rani PingaliJ C ShobhaA Praveen ReddyBackground: The Stroop paradigm evaluates susceptibility to interference and is sensitive to dysfunction in frontal lobes and drug effects. The aim of the present study was to establish a simple and reliable computerized version of Stroop color-word test, which can be used for screening of various psychotropic drugs. Materials and Methods: The standardized method was followed in all cases, by recording the reaction time (RT) in msec in 24 healthy participants using computerized version of Stroop color-word test. Reproducibility of the test procedure was evaluated by recording the RTs by a single experimenter on two sessions (interday reproducibility). Validity of the model was further tested by evaluating the psychotropic effect of Zolpidem 5 mg, Caffeine 500 mg, or Placebo on 24 healthy subjects in a randomized, double blind three-way crossover design. Results: The method was found to produce low variability with coefficient of variation less than 10%. Interday reproducibility was very good as shown by Bland-Altman plot with most of the values within ±2SD. There was a significant increase in RTs in Stroop performance with Zolpidem at 1 hr and 2 hrs; in contrast, caffeine significantly decreased RTs in Stroop performance at 1 hr only compared to placebo. Conclusion: The Stroop color-word recording and analysis system is simple, sensitive to centrally acting drug effects, and has potential for future experimental psychomotor assessment studies.http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=2;spage=180;epage=189;aulast=PilliAttentioncognitionneuropsychologystroop interference |
| spellingShingle | Raveendranadh Pilli MUR Naidu Usha Rani Pingali J C Shobha A Praveen Reddy A computerized stroop test for the evaluation of psychotropic drugs in healthy participants Indian Journal of Psychological Medicine Attention cognition neuropsychology stroop interference |
| title | A computerized stroop test for the evaluation of psychotropic drugs in healthy participants |
| title_full | A computerized stroop test for the evaluation of psychotropic drugs in healthy participants |
| title_fullStr | A computerized stroop test for the evaluation of psychotropic drugs in healthy participants |
| title_full_unstemmed | A computerized stroop test for the evaluation of psychotropic drugs in healthy participants |
| title_short | A computerized stroop test for the evaluation of psychotropic drugs in healthy participants |
| title_sort | computerized stroop test for the evaluation of psychotropic drugs in healthy participants |
| topic | Attention cognition neuropsychology stroop interference |
| url | http://www.ijpm.info/article.asp?issn=0253-7176;year=2013;volume=35;issue=2;spage=180;epage=189;aulast=Pilli |
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