Human umbilical cord mesenchymal stem cells derived exosome shuttling mir-129-5p attenuates inflammatory bowel disease by inhibiting ferroptosis

Human umbilical cord mesenchymal stem cells derived exosome shuttling mir-129-5p attenuates inflammatory bowel disease by inhibiting ferroptosis

Abstract Background Ferroptosis, a unique form of non-apoptotic cell death, is dependent on iron and lipoperoxidation, and has been shown to be associated with the pathogenesis of inflammatory bowel disease (IBD). Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) are involved i...

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Bibliographic Details
Main Authors: Zhiping Wei, Sanhua Hang, Dickson Kofi Wiredu Ocansey, Zhaoyang Zhang, Bo Wang, Xu Zhang, Fei Mao
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Nanobiotechnology
Subjects:
Mesenchymal stem cell-derived exosomes
Ferroptosis
miR-129-5p
Inflammatory bowel disease
ACSL4
Lipid peroxidation
Online Access:https://doi.org/10.1186/s12951-023-01951-x

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