Multifunctional phototheranostic agent ZnO@Ag for anti-infection through photothermal/photodynamic therapy
To overcome the limitations of traditional therapeutics, nanotechnology offers a synergistic therapeutic approach for the treatment of bacterial infection and biofilms that has attracted attention. Herein, we report on a ZnO@Ag nanocomposite with good biocompatibility synthesized by doping ZnO NPs w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.1054739/full |
| _version_ | 1811231355773648896 |
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| author | Enoch Obeng Jiayao Feng Danyan Wang Dongyang Zheng Bailin Xiang Jianliang Shen Jianliang Shen |
| author_facet | Enoch Obeng Jiayao Feng Danyan Wang Dongyang Zheng Bailin Xiang Jianliang Shen Jianliang Shen |
| author_sort | Enoch Obeng |
| collection | DOAJ |
| description | To overcome the limitations of traditional therapeutics, nanotechnology offers a synergistic therapeutic approach for the treatment of bacterial infection and biofilms that has attracted attention. Herein, we report on a ZnO@Ag nanocomposite with good biocompatibility synthesized by doping ZnO NPs with silver nanoparticles (Ag NPs). ZnO@Ag nanocomposites were synthesized with varying ratios of Ag NPs (0.5%, 2%, 8%). Under the same experimental conditions, ZnO@8%Ag exhibited outstanding properties compared to the other nanocomposites and the pristine ZnO NPs. ZnO@8%Ag demonstrated excellent photothermal and photodynamic properties. Also, ZnO@8%Ag demonstrated over 99% inhibition of Staphylococcus aureus (S. aureus) under photothermal therapy (PTT) or photodynamics therapy (PDT) as a result of the excessive generation of reactive oxygen species (ROS) by the Ag+ released, while the pristine ZnO showed an insignificant inhibition rate compared to the PBS group (control). Furthermore, ZnO@8%Ag completely disrupted S. aureus biofilm under a combined PTT/PDT treatment, a synergetic trimodal therapy, although the molecular mechanism of biofilm inhibition remains unclear. Hence, the excellent photothermal, photodynamic, biocompatibility, and bactericidal properties of ZnO@8%Ag present it as an appropriate platform for bacterial and biofilm treatment or other biomedically related applications. |
| first_indexed | 2024-04-12T10:43:53Z |
| format | Article |
| id | doaj.art-a4070295ed2c4bada85374ab09b7532c |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-12T10:43:53Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-a4070295ed2c4bada85374ab09b7532c2022-12-22T03:36:31ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-11-011010.3389/fchem.2022.10547391054739Multifunctional phototheranostic agent ZnO@Ag for anti-infection through photothermal/photodynamic therapyEnoch Obeng0Jiayao Feng1Danyan Wang2Dongyang Zheng3Bailin Xiang4Jianliang Shen5Jianliang Shen6School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaNingbo Eye Hospital, Ningbo, Zhejiang, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaCollege of Chemistry and Materials Engineering, Huaihua University, Huaihua, ChinaSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaTo overcome the limitations of traditional therapeutics, nanotechnology offers a synergistic therapeutic approach for the treatment of bacterial infection and biofilms that has attracted attention. Herein, we report on a ZnO@Ag nanocomposite with good biocompatibility synthesized by doping ZnO NPs with silver nanoparticles (Ag NPs). ZnO@Ag nanocomposites were synthesized with varying ratios of Ag NPs (0.5%, 2%, 8%). Under the same experimental conditions, ZnO@8%Ag exhibited outstanding properties compared to the other nanocomposites and the pristine ZnO NPs. ZnO@8%Ag demonstrated excellent photothermal and photodynamic properties. Also, ZnO@8%Ag demonstrated over 99% inhibition of Staphylococcus aureus (S. aureus) under photothermal therapy (PTT) or photodynamics therapy (PDT) as a result of the excessive generation of reactive oxygen species (ROS) by the Ag+ released, while the pristine ZnO showed an insignificant inhibition rate compared to the PBS group (control). Furthermore, ZnO@8%Ag completely disrupted S. aureus biofilm under a combined PTT/PDT treatment, a synergetic trimodal therapy, although the molecular mechanism of biofilm inhibition remains unclear. Hence, the excellent photothermal, photodynamic, biocompatibility, and bactericidal properties of ZnO@8%Ag present it as an appropriate platform for bacterial and biofilm treatment or other biomedically related applications.https://www.frontiersin.org/articles/10.3389/fchem.2022.1054739/fullZnO@Ag nanocompositephotothermal therapyphotodynamic therapysynergistic effectanti-infective therapy |
| spellingShingle | Enoch Obeng Jiayao Feng Danyan Wang Dongyang Zheng Bailin Xiang Jianliang Shen Jianliang Shen Multifunctional phototheranostic agent ZnO@Ag for anti-infection through photothermal/photodynamic therapy Frontiers in Chemistry ZnO@Ag nanocomposite photothermal therapy photodynamic therapy synergistic effect anti-infective therapy |
| title | Multifunctional phototheranostic agent ZnO@Ag for anti-infection through photothermal/photodynamic therapy |
| title_full | Multifunctional phototheranostic agent ZnO@Ag for anti-infection through photothermal/photodynamic therapy |
| title_fullStr | Multifunctional phototheranostic agent ZnO@Ag for anti-infection through photothermal/photodynamic therapy |
| title_full_unstemmed | Multifunctional phototheranostic agent ZnO@Ag for anti-infection through photothermal/photodynamic therapy |
| title_short | Multifunctional phototheranostic agent ZnO@Ag for anti-infection through photothermal/photodynamic therapy |
| title_sort | multifunctional phototheranostic agent zno ag for anti infection through photothermal photodynamic therapy |
| topic | ZnO@Ag nanocomposite photothermal therapy photodynamic therapy synergistic effect anti-infective therapy |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.1054739/full |
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