Reduced Insulin Signaling Targeted to Serotonergic Neurons but Not Other Neuronal Subtypes Extends Lifespan in Drosophila melanogaster

Reduced Insulin Signaling Targeted to Serotonergic Neurons but Not Other Neuronal Subtypes Extends Lifespan in Drosophila melanogaster

Reduced Insulin/IGF-like signaling (IIS) plays an evolutionarily conserved role in improving longevity and some measures of health-span in model organisms. Recent studies, however, have found a disconnection between lifespan extension and behavioral health-span. We have previously shown that reducti...

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Bibliographic Details
Main Authors: Nikolett Dravecz, Tommy Shaw, Isabella Davies, Casey Brown, Lewis Ormerod, Gin Vu, Tyler Walker, Taran Taank, Alan D. Shirras, Susan J. Broughton
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
ageing
behavioral senescence
insulin/IGF-like signaling
serotonergic neurons
Drosophila
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.893444/full

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