Infarct growth velocity predicts early neurological outcomes in single subcortical infarction
Abstract In single subcortical infarction (SSI), changes in lesion size are a major determinant of early neurological deterioration. We evaluated the association between END and infarct growth velocity (IGV) in patients with SSI. We included consecutive patients with SSI who underwent MRI within 24 ...
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| Format: | Article |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-31727-0 |
| _version_ | 1797865139925417984 |
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| author | Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee |
| author_facet | Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee |
| author_sort | Ki-Woong Nam |
| collection | DOAJ |
| description | Abstract In single subcortical infarction (SSI), changes in lesion size are a major determinant of early neurological deterioration. We evaluated the association between END and infarct growth velocity (IGV) in patients with SSI. We included consecutive patients with SSI who underwent MRI within 24 h of symptom onset between 2010 and 2020. END was defined as an increase of ≥ 2 in the total National Institutes of Health Stroke Scale (NIHSS) score or ≥ 1 in the motor NIHSS score. IGV was calculated using the following formula: IGV (mL/h) = diffusion-weighted imaging volume (mL)/time to MRI (h). A total of 604 patients with SSI were evaluated. Multivariable logistic regression analysis showed that IGV remained significant after adjusting for confounders (aOR = 1.34, 95% CI 1.12–1.61). In a subgroup analysis based on the type of SSI, only patients with distal SSI showed an association between IGV and END (aOR = 1.64, 95% CI 1.24–2.16). In patients with proximal SSI, IGV did not show any statistical association with END. In conclusion, IGV was positively associated with END in patients with SSI. IGV should be interpreted differently in clinical settings depending on the location of the SSI lesion. |
| first_indexed | 2024-04-09T23:03:09Z |
| format | Article |
| id | doaj.art-a407bfdeba2842fb886f2c0bfd4988dc |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:03:09Z |
| publishDate | 2023-03-01 |
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| series | Scientific Reports |
| spelling | doaj.art-a407bfdeba2842fb886f2c0bfd4988dc2023-03-22T10:51:34ZengNature PortfolioScientific Reports2045-23222023-03-011311910.1038/s41598-023-31727-0Infarct growth velocity predicts early neurological outcomes in single subcortical infarctionKi-Woong Nam0Hyung-Min Kwon1Yong-Seok Lee2Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical CenterDepartment of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical CenterDepartment of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical CenterAbstract In single subcortical infarction (SSI), changes in lesion size are a major determinant of early neurological deterioration. We evaluated the association between END and infarct growth velocity (IGV) in patients with SSI. We included consecutive patients with SSI who underwent MRI within 24 h of symptom onset between 2010 and 2020. END was defined as an increase of ≥ 2 in the total National Institutes of Health Stroke Scale (NIHSS) score or ≥ 1 in the motor NIHSS score. IGV was calculated using the following formula: IGV (mL/h) = diffusion-weighted imaging volume (mL)/time to MRI (h). A total of 604 patients with SSI were evaluated. Multivariable logistic regression analysis showed that IGV remained significant after adjusting for confounders (aOR = 1.34, 95% CI 1.12–1.61). In a subgroup analysis based on the type of SSI, only patients with distal SSI showed an association between IGV and END (aOR = 1.64, 95% CI 1.24–2.16). In patients with proximal SSI, IGV did not show any statistical association with END. In conclusion, IGV was positively associated with END in patients with SSI. IGV should be interpreted differently in clinical settings depending on the location of the SSI lesion.https://doi.org/10.1038/s41598-023-31727-0 |
| spellingShingle | Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee Infarct growth velocity predicts early neurological outcomes in single subcortical infarction Scientific Reports |
| title | Infarct growth velocity predicts early neurological outcomes in single subcortical infarction |
| title_full | Infarct growth velocity predicts early neurological outcomes in single subcortical infarction |
| title_fullStr | Infarct growth velocity predicts early neurological outcomes in single subcortical infarction |
| title_full_unstemmed | Infarct growth velocity predicts early neurological outcomes in single subcortical infarction |
| title_short | Infarct growth velocity predicts early neurological outcomes in single subcortical infarction |
| title_sort | infarct growth velocity predicts early neurological outcomes in single subcortical infarction |
| url | https://doi.org/10.1038/s41598-023-31727-0 |
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