Management of Ocular Surface Tumors: Excision vs. Topical Treatment
Ocular surface squamous neoplasia (OSSN) encompasses a range of corneal and conjunctival lesions from intraepithelial dysplasia to invasive squamous cell carcinoma. The mainstay of treatment for OSSN has traditionally been surgical excision with wide margins and cryotherapy. Increasing...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pan-American Association of Ophthalmology
2014-10-01
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| Series: | Vision Pan-America |
| Subjects: | |
| Online Access: | http://journals.sfu.ca/paao/index.php/journal/article/view/213 |
| Summary: | Ocular surface squamous neoplasia
(OSSN) encompasses a range of corneal
and conjunctival lesions from intraepithelial
dysplasia to invasive squamous cell
carcinoma. The mainstay of treatment
for OSSN has traditionally been surgical
excision with wide margins and cryotherapy.
Increasing evidence on the efficacy and
safety of medical therapy and the avoidance
of surgical complications has made topical
chemotherapy increasingly popular among
corneal specialists. The most common topical
agents used for the treatment of OSSN include
mitomycin C, 5-fluorouracil, and interferon
a 2b. Herein, we review recent advances in the
surgical and medical management of OSSN
and discuss advantages and disadvantages
of each approach. The role of ultra highresolution
optical coherence tomography in
the diagnosis and treatment of primary and
recurrent OSSN lesions is also discussed. |
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| ISSN: | 2219-4665 2219-4673 |