External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study
Abstract No established predictive or risk classification tool exists for the neurological outcomes of post-cardiac arrest syndrome (PCAS) in patients with in-hospital cardiac arrest (IHCA). This study aimed to investigate whether the revised post-cardiac arrest syndrome for therapeutic hypothermia...
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Nature Portfolio
2024-02-01
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| Online Access: | https://doi.org/10.1038/s41598-024-54851-x |
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| author | Junki Ishii Mitsuaki Nishikimi Kazuya Kikutani Michihito Kyo Shingo Ohki Kohei Ota Mitsuhiro Fujino Masaaki Sakuraya Shinichiro Ohshimo Nobuaki Shime |
| author_facet | Junki Ishii Mitsuaki Nishikimi Kazuya Kikutani Michihito Kyo Shingo Ohki Kohei Ota Mitsuhiro Fujino Masaaki Sakuraya Shinichiro Ohshimo Nobuaki Shime |
| author_sort | Junki Ishii |
| collection | DOAJ |
| description | Abstract No established predictive or risk classification tool exists for the neurological outcomes of post-cardiac arrest syndrome (PCAS) in patients with in-hospital cardiac arrest (IHCA). This study aimed to investigate whether the revised post-cardiac arrest syndrome for therapeutic hypothermia score (rCAST), which was developed to estimate the prognosis of PCAS patients with out-of-hospital cardiac arrest (OHCA), was applicable to patients with IHCA. A retrospective, multicenter observational study of 140 consecutive adult IHCA patients admitted to three intensive care units. The area under the receiver operating characteristic curves (AUCs) of the rCAST for poor neurological outcome and mortality at 30 days were 0.88 (0.82–0.93) and 0.83 (0.76–0.89), respectively. The sensitivity and specificity of the risk classification according to rCAST for poor neurological outcomes were 0.90 (0.83–0.96) and 0.67 (0.55–0.79) for the low, 0.63 (0.54–0.74) and 0.67 (0.55–0.79) for the moderate, and 0.27 (0.17–0.37) and 1.00 (1.00–1.00) for the high-severity grades. All 22 patients classified with a high-severity grade showed poor neurological outcomes. The rCAST showed excellent predictive accuracy for neurological prognosis in patients with PCAS after IHCA. The rCAST may be useful as a risk classification tool for PCAS after IHCA. |
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| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:02:33Z |
| publishDate | 2024-02-01 |
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| series | Scientific Reports |
| spelling | doaj.art-a40a58f1184543958d9961348e13f39f2024-03-05T19:03:32ZengNature PortfolioScientific Reports2045-23222024-02-011411910.1038/s41598-024-54851-xExternal validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational studyJunki Ishii0Mitsuaki Nishikimi1Kazuya Kikutani2Michihito Kyo3Shingo Ohki4Kohei Ota5Mitsuhiro Fujino6Masaaki Sakuraya7Shinichiro Ohshimo8Nobuaki Shime9Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Critical Care and Emergency Medicine, Otsu City HospitalDepartment of Emergency and Intensive Care Medicine, JA Hiroshima General HospitalDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityAbstract No established predictive or risk classification tool exists for the neurological outcomes of post-cardiac arrest syndrome (PCAS) in patients with in-hospital cardiac arrest (IHCA). This study aimed to investigate whether the revised post-cardiac arrest syndrome for therapeutic hypothermia score (rCAST), which was developed to estimate the prognosis of PCAS patients with out-of-hospital cardiac arrest (OHCA), was applicable to patients with IHCA. A retrospective, multicenter observational study of 140 consecutive adult IHCA patients admitted to three intensive care units. The area under the receiver operating characteristic curves (AUCs) of the rCAST for poor neurological outcome and mortality at 30 days were 0.88 (0.82–0.93) and 0.83 (0.76–0.89), respectively. The sensitivity and specificity of the risk classification according to rCAST for poor neurological outcomes were 0.90 (0.83–0.96) and 0.67 (0.55–0.79) for the low, 0.63 (0.54–0.74) and 0.67 (0.55–0.79) for the moderate, and 0.27 (0.17–0.37) and 1.00 (1.00–1.00) for the high-severity grades. All 22 patients classified with a high-severity grade showed poor neurological outcomes. The rCAST showed excellent predictive accuracy for neurological prognosis in patients with PCAS after IHCA. The rCAST may be useful as a risk classification tool for PCAS after IHCA.https://doi.org/10.1038/s41598-024-54851-xPost-cardiac arrest syndromeNeurological prognosisIn-hospital cardiac arrestRisk classificationrCAST |
| spellingShingle | Junki Ishii Mitsuaki Nishikimi Kazuya Kikutani Michihito Kyo Shingo Ohki Kohei Ota Mitsuhiro Fujino Masaaki Sakuraya Shinichiro Ohshimo Nobuaki Shime External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study Scientific Reports Post-cardiac arrest syndrome Neurological prognosis In-hospital cardiac arrest Risk classification rCAST |
| title | External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study |
| title_full | External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study |
| title_fullStr | External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study |
| title_full_unstemmed | External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study |
| title_short | External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study |
| title_sort | external validation of the rcast for patients after in hospital cardiac arrest a multicenter retrospective observational study |
| topic | Post-cardiac arrest syndrome Neurological prognosis In-hospital cardiac arrest Risk classification rCAST |
| url | https://doi.org/10.1038/s41598-024-54851-x |
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