Patients' perspectives on buprenorphine subcutaneous implant: a case series
Abstract Background Considering the enormous burden represented by the opioid use disorder (OUD), it is important to always consider, when implementing opioid agonist therapy (OAT), the potential impact on patient’s adherence, quality of life, and detoxification. Thus, the purpose of the study is to...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-024-04483-6 |
| _version_ | 1797219816213315584 |
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| author | Claudio Pierlorenzi Marco Nunzi Sabino Cirulli Giovanni Francesco Maria Direnzo Lucia Curatella Sandra Liberatori Annalisa Pascucci Edoardo Petrone Generoso Ventre Concettina Varango Maria Luisa Pulito Antonella Varango Cosimo Dandolo Brunella Occupati Roberta Marenzi Claudio Leonardi |
| author_facet | Claudio Pierlorenzi Marco Nunzi Sabino Cirulli Giovanni Francesco Maria Direnzo Lucia Curatella Sandra Liberatori Annalisa Pascucci Edoardo Petrone Generoso Ventre Concettina Varango Maria Luisa Pulito Antonella Varango Cosimo Dandolo Brunella Occupati Roberta Marenzi Claudio Leonardi |
| author_sort | Claudio Pierlorenzi |
| collection | DOAJ |
| description | Abstract Background Considering the enormous burden represented by the opioid use disorder (OUD), it is important to always consider, when implementing opioid agonist therapy (OAT), the potential impact on patient’s adherence, quality of life, and detoxification. Thus, the purpose of the study is to evaluate how the introduction of a novel OAT approach influences these key factors in the management of OUD. Case presentation This article marks the pioneering use of OAT through buprenorphine implant in Europe and delves into the experience of six patients diagnosed with OUD at a relatively young age. The patients, comprising both males and a female, are of Caucasian Italian and African Italian ancestry (case 4) and exhibit an age range from 23 to 63, with an average drug abuse history of 19 ± 12 years. All patients were on stable traditional OAT before transitioning to buprenorphine implants. Despite the heterogeneity in social and educational backgrounds, health status, and drug abuse initiation histories, the case series reveals consistent positive treatment outcomes such as detoxification, absence of withdrawal symptoms and of side effects. Notably, all patients reported experiencing a newfound sense of freedom and improved quality of life. Conclusions These results emphasise the promising impact of OAT via buprenorphine implants in enhancing the well-being and quality of life in the context of OUD. |
| first_indexed | 2024-04-24T12:39:39Z |
| format | Article |
| id | doaj.art-a40a8508fab04607bb4a372dbecd66b2 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-24T12:39:39Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-a40a8508fab04607bb4a372dbecd66b22024-04-07T11:19:50ZengBMCJournal of Medical Case Reports1752-19472024-04-0118111510.1186/s13256-024-04483-6Patients' perspectives on buprenorphine subcutaneous implant: a case seriesClaudio Pierlorenzi0Marco Nunzi1Sabino Cirulli2Giovanni Francesco Maria Direnzo3Lucia Curatella4Sandra Liberatori5Annalisa Pascucci6Edoardo Petrone7Generoso Ventre8Concettina Varango9Maria Luisa Pulito10Antonella Varango11Cosimo Dandolo12Brunella Occupati13Roberta Marenzi14Claudio Leonardi15UOS Patologie da Dipendenza D9 ASL Roma 2UOS Patologie da Dipendenza D9 ASL Roma 2UOS Patologie da Dipendenza D9 ASL Roma 2UOC Patologie da Dipendenza D8 ASL Roma 2UOS Patologie da Dipendenza D9 ASL Roma 2UOC Patologie da Dipendenza D8 ASL Roma 2UOC Patologie da Dipendenza D8 ASL Roma 2UOS Terapia del Dolore ASL Roma 2 Ospedale S. EugenioUOC Patologie da Dipendenza D8 ASL Roma 2Servizio Dipendenze Casalpusterlengo, ASST LodiServizio Dipendenze Casalpusterlengo, ASST LodiServizio Dipendenze Casalpusterlengo, ASST LodiServizio Dipendenze Casalpusterlengo, ASST LodiTossicologia Medica, Azienda Ospedaliero Universitaria CareggiASST Papa Giovanni XXII, Ospedale Di BergamoDipartimento Tutela Delle Fragilità ASL Roma 2Abstract Background Considering the enormous burden represented by the opioid use disorder (OUD), it is important to always consider, when implementing opioid agonist therapy (OAT), the potential impact on patient’s adherence, quality of life, and detoxification. Thus, the purpose of the study is to evaluate how the introduction of a novel OAT approach influences these key factors in the management of OUD. Case presentation This article marks the pioneering use of OAT through buprenorphine implant in Europe and delves into the experience of six patients diagnosed with OUD at a relatively young age. The patients, comprising both males and a female, are of Caucasian Italian and African Italian ancestry (case 4) and exhibit an age range from 23 to 63, with an average drug abuse history of 19 ± 12 years. All patients were on stable traditional OAT before transitioning to buprenorphine implants. Despite the heterogeneity in social and educational backgrounds, health status, and drug abuse initiation histories, the case series reveals consistent positive treatment outcomes such as detoxification, absence of withdrawal symptoms and of side effects. Notably, all patients reported experiencing a newfound sense of freedom and improved quality of life. Conclusions These results emphasise the promising impact of OAT via buprenorphine implants in enhancing the well-being and quality of life in the context of OUD.https://doi.org/10.1186/s13256-024-04483-6Buprenorphine implantOpioid agonist therapyOpioid use disorderSublingual buprenorphine |
| spellingShingle | Claudio Pierlorenzi Marco Nunzi Sabino Cirulli Giovanni Francesco Maria Direnzo Lucia Curatella Sandra Liberatori Annalisa Pascucci Edoardo Petrone Generoso Ventre Concettina Varango Maria Luisa Pulito Antonella Varango Cosimo Dandolo Brunella Occupati Roberta Marenzi Claudio Leonardi Patients' perspectives on buprenorphine subcutaneous implant: a case series Journal of Medical Case Reports Buprenorphine implant Opioid agonist therapy Opioid use disorder Sublingual buprenorphine |
| title | Patients' perspectives on buprenorphine subcutaneous implant: a case series |
| title_full | Patients' perspectives on buprenorphine subcutaneous implant: a case series |
| title_fullStr | Patients' perspectives on buprenorphine subcutaneous implant: a case series |
| title_full_unstemmed | Patients' perspectives on buprenorphine subcutaneous implant: a case series |
| title_short | Patients' perspectives on buprenorphine subcutaneous implant: a case series |
| title_sort | patients perspectives on buprenorphine subcutaneous implant a case series |
| topic | Buprenorphine implant Opioid agonist therapy Opioid use disorder Sublingual buprenorphine |
| url | https://doi.org/10.1186/s13256-024-04483-6 |
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