Long-term results of radiofrequency and microwave ablation of colorectal cancer liver metastasis
Background : : Radiofrequency ablation (RFA) or microwave ablation (MWA) is effective for colorectal cancer liver metastases. We aimed to investigate the impact of different variables on survival. <br />Methods : : Sixty-four patients (142 lesions) who underwent thermoablation between January...
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| Format: | Article |
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Society of Gastrointestinal Intervention
2023-07-01
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| Series: | International Journal of Gastrointestinal Intervention |
| Subjects: | |
| Online Access: | https://www.ijgii.org/journal/view.html?doi=10.18528/ijgii230019 |
| _version_ | 1797770622813601792 |
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| author | Ahmet Gürkan Erdemir Sevilay Karahan Emre Ünal Türkmen Turan Çiftçi Devrim Akıncı Şuayib Yalçın Okan Akhan |
| author_facet | Ahmet Gürkan Erdemir Sevilay Karahan Emre Ünal Türkmen Turan Çiftçi Devrim Akıncı Şuayib Yalçın Okan Akhan |
| author_sort | Ahmet Gürkan Erdemir |
| collection | DOAJ |
| description | Background : : Radiofrequency ablation (RFA) or microwave ablation (MWA) is effective for colorectal cancer liver metastases. We aimed to investigate the impact of different variables on survival. <br />Methods : : Sixty-four patients (142 lesions) who underwent thermoablation between January 2007 and January 2019 were retrospectively analyzed. The overall survival (OS) and liver progression-free survival (Li-PFS) were compared using Kaplan-Meier analysis. Univariable and multivariable Cox-regression were done to identify prognostic factors. <br />Results : : No significant difference was found between median OS (59.39 months) and Li-PFS (41.22 months) of patients who received MWA (n = 33); and median OS (61.00 months) and Li-PFS (53.43 months) of patients who received RFA (n = 31) (OS: P = 0.697; Li-PFS: P = 0.122). The median OS and Li-PFS were significantly decreased with lung metastases and K-ras mutations (P < 0.001). There was no correlation between prior systemic chemotherapy (n = 25) and both outcome parameters (OS: P = 0.613; Li-PFS: P = 0.665). No significant difference was observed in patients with lesions less than 30 mm diameter (n = 44) whether they received prior systemic chemotherapy (n = 17) or not (n = 27) (OS: P = 0.27; Li-PFS: P = 0.42). Similarly, in patients with a lesion of 3-5 cm diameter (n = 20; eight of them had prior chemotherapy), there was no correlation for both outcomes (OS: P = 0.069; Li-PFS: P = 0.71). The most important prognostic factor was concomitant lung metastases (hazard ratio = 3.689, P = 0.002). <br />Conclusion : : Concomitant lung metastasis and mutant K-ras were associated with shorter survival. Survival did not differ significantly regarding thermoablation technique or prior systemic chemotherapy. However, in the patient group with lung metastases, curative treatments had better survival than patients who received chemotherapy only. Additional therapeutic options should be considered in patients with concomitant lung metastasis. |
| first_indexed | 2024-03-12T21:25:52Z |
| format | Article |
| id | doaj.art-a40bf6f6700645e8885146901b2c2a49 |
| institution | Directory Open Access Journal |
| issn | 2636-0004 |
| language | English |
| last_indexed | 2024-03-12T21:25:52Z |
| publishDate | 2023-07-01 |
| publisher | Society of Gastrointestinal Intervention |
| record_format | Article |
| series | International Journal of Gastrointestinal Intervention |
| spelling | doaj.art-a40bf6f6700645e8885146901b2c2a492023-07-28T08:58:06ZengSociety of Gastrointestinal InterventionInternational Journal of Gastrointestinal Intervention2636-00042023-07-0112313013910.18528/ijgii230019ijgii230019Long-term results of radiofrequency and microwave ablation of colorectal cancer liver metastasisAhmet Gürkan Erdemir0Sevilay Karahan1Emre Ünal2Türkmen Turan Çiftçi3Devrim Akıncı4Şuayib Yalçın5Okan Akhan6Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara, TurkeyDepartment of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, TurkeyDepartment of Radiology, Faculty of Medicine, Hacettepe University, Ankara, TurkeyDepartment of Radiology, Faculty of Medicine, Hacettepe University, Ankara, TurkeyDepartment of Radiology, Faculty of Medicine, Hacettepe University, Ankara, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Hacettepe University, Ankara, TurkeyDepartment of Radiology, Faculty of Medicine, Hacettepe University, Ankara, TurkeyBackground : : Radiofrequency ablation (RFA) or microwave ablation (MWA) is effective for colorectal cancer liver metastases. We aimed to investigate the impact of different variables on survival. <br />Methods : : Sixty-four patients (142 lesions) who underwent thermoablation between January 2007 and January 2019 were retrospectively analyzed. The overall survival (OS) and liver progression-free survival (Li-PFS) were compared using Kaplan-Meier analysis. Univariable and multivariable Cox-regression were done to identify prognostic factors. <br />Results : : No significant difference was found between median OS (59.39 months) and Li-PFS (41.22 months) of patients who received MWA (n = 33); and median OS (61.00 months) and Li-PFS (53.43 months) of patients who received RFA (n = 31) (OS: P = 0.697; Li-PFS: P = 0.122). The median OS and Li-PFS were significantly decreased with lung metastases and K-ras mutations (P < 0.001). There was no correlation between prior systemic chemotherapy (n = 25) and both outcome parameters (OS: P = 0.613; Li-PFS: P = 0.665). No significant difference was observed in patients with lesions less than 30 mm diameter (n = 44) whether they received prior systemic chemotherapy (n = 17) or not (n = 27) (OS: P = 0.27; Li-PFS: P = 0.42). Similarly, in patients with a lesion of 3-5 cm diameter (n = 20; eight of them had prior chemotherapy), there was no correlation for both outcomes (OS: P = 0.069; Li-PFS: P = 0.71). The most important prognostic factor was concomitant lung metastases (hazard ratio = 3.689, P = 0.002). <br />Conclusion : : Concomitant lung metastasis and mutant K-ras were associated with shorter survival. Survival did not differ significantly regarding thermoablation technique or prior systemic chemotherapy. However, in the patient group with lung metastases, curative treatments had better survival than patients who received chemotherapy only. Additional therapeutic options should be considered in patients with concomitant lung metastasis.https://www.ijgii.org/journal/view.html?doi=10.18528/ijgii230019ablation techniques; colorectal neoplasms; drug therapy; genesras; survival analysis |
| spellingShingle | Ahmet Gürkan Erdemir Sevilay Karahan Emre Ünal Türkmen Turan Çiftçi Devrim Akıncı Şuayib Yalçın Okan Akhan Long-term results of radiofrequency and microwave ablation of colorectal cancer liver metastasis International Journal of Gastrointestinal Intervention ablation techniques; colorectal neoplasms; drug therapy; genes ras; survival analysis |
| title | Long-term results of radiofrequency and microwave ablation of colorectal cancer liver metastasis |
| title_full | Long-term results of radiofrequency and microwave ablation of colorectal cancer liver metastasis |
| title_fullStr | Long-term results of radiofrequency and microwave ablation of colorectal cancer liver metastasis |
| title_full_unstemmed | Long-term results of radiofrequency and microwave ablation of colorectal cancer liver metastasis |
| title_short | Long-term results of radiofrequency and microwave ablation of colorectal cancer liver metastasis |
| title_sort | long term results of radiofrequency and microwave ablation of colorectal cancer liver metastasis |
| topic | ablation techniques; colorectal neoplasms; drug therapy; genes ras; survival analysis |
| url | https://www.ijgii.org/journal/view.html?doi=10.18528/ijgii230019 |
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