Dieckol Isolated from <i>Eisenia bicyclis</i> Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless Mice
Repetitive exposure to ultraviolet B (UVB) is one of the main causes of skin photoaging. We previously reported that dieckol isolated from <i>Eisenia bicyclis</i> extract has potential anti-photoaging effects in UVB-irradiated Hs68 cells. Here, we aimed to evaluate the anti-photoaging ac...
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MDPI AG
2022-12-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/12/779 |
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| author | Jae-Min Kim Kyung-Sook Chung Young-Seo Yoon Seo-Yun Jang So-Won Heo Geonha Park Young-Pyo Jang Hye-Shin Ahn Yu-Kyong Shin Sun-Hee Lee Kyung-Tae Lee |
| author_facet | Jae-Min Kim Kyung-Sook Chung Young-Seo Yoon Seo-Yun Jang So-Won Heo Geonha Park Young-Pyo Jang Hye-Shin Ahn Yu-Kyong Shin Sun-Hee Lee Kyung-Tae Lee |
| author_sort | Jae-Min Kim |
| collection | DOAJ |
| description | Repetitive exposure to ultraviolet B (UVB) is one of the main causes of skin photoaging. We previously reported that dieckol isolated from <i>Eisenia bicyclis</i> extract has potential anti-photoaging effects in UVB-irradiated Hs68 cells. Here, we aimed to evaluate the anti-photoaging activity of dieckol in a UVB-irradiated hairless mouse model. In this study, hairless mice were exposed to UVB for eight weeks. At the same time, dieckol at two doses (5 or 10 mg/kg) was administered orally three times a week. We found that dieckol suppressed UVB-induced collagen degradation and matrix metalloproteinases (MMPs)-1, -3, and -9 expression by regulating transforming growth factor beta (TGF-β)/Smad2/3 and mitogen-activated protein kinases (MAPKs)/activator protein-1 (AP-1) signaling. In addition, dieckol rescued the production of hyaluronic acid (HA) and effectively restored the mRNA expression of hyaluronan synthase (HAS)-1/-2 and hyaluronidase (HYAL)-1/-2 in UVB-irradiated hairless mice. We observed a significant reduction in transepidermal water loss (TEWL), epidermal/dermal thickness, and wrinkle formation in hairless mice administered dieckol. Based on these results, we suggest that dieckol, due to its anti-photoaging role, may be used as a nutricosmetic ingredient for improving skin health. |
| first_indexed | 2024-03-09T16:10:14Z |
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| language | English |
| last_indexed | 2024-03-09T16:10:14Z |
| publishDate | 2022-12-01 |
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| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a40c7e3a87be455cb0d85edf3b1dcee72023-11-24T16:20:03ZengMDPI AGMarine Drugs1660-33972022-12-01201277910.3390/md20120779Dieckol Isolated from <i>Eisenia bicyclis</i> Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless MiceJae-Min Kim0Kyung-Sook Chung1Young-Seo Yoon2Seo-Yun Jang3So-Won Heo4Geonha Park5Young-Pyo Jang6Hye-Shin Ahn7Yu-Kyong Shin8Sun-Hee Lee9Kyung-Tae Lee10Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of KoreaDepartment of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of KoreaDepartment of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of KoreaDepartment of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of KoreaDepartment of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of KoreaDepartment of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of KoreaDepartment of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of KoreaDepartment of New Material Development, COSMAXBIO, Seongnam 13486, Republic of KoreaDepartment of New Material Development, COSMAXBIO, Seongnam 13486, Republic of KoreaDepartment of New Material Development, COSMAXBIO, Seongnam 13486, Republic of KoreaDepartment of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of KoreaRepetitive exposure to ultraviolet B (UVB) is one of the main causes of skin photoaging. We previously reported that dieckol isolated from <i>Eisenia bicyclis</i> extract has potential anti-photoaging effects in UVB-irradiated Hs68 cells. Here, we aimed to evaluate the anti-photoaging activity of dieckol in a UVB-irradiated hairless mouse model. In this study, hairless mice were exposed to UVB for eight weeks. At the same time, dieckol at two doses (5 or 10 mg/kg) was administered orally three times a week. We found that dieckol suppressed UVB-induced collagen degradation and matrix metalloproteinases (MMPs)-1, -3, and -9 expression by regulating transforming growth factor beta (TGF-β)/Smad2/3 and mitogen-activated protein kinases (MAPKs)/activator protein-1 (AP-1) signaling. In addition, dieckol rescued the production of hyaluronic acid (HA) and effectively restored the mRNA expression of hyaluronan synthase (HAS)-1/-2 and hyaluronidase (HYAL)-1/-2 in UVB-irradiated hairless mice. We observed a significant reduction in transepidermal water loss (TEWL), epidermal/dermal thickness, and wrinkle formation in hairless mice administered dieckol. Based on these results, we suggest that dieckol, due to its anti-photoaging role, may be used as a nutricosmetic ingredient for improving skin health.https://www.mdpi.com/1660-3397/20/12/779dieckolphotoagingultraviolet BMMPscollagenMAPK |
| spellingShingle | Jae-Min Kim Kyung-Sook Chung Young-Seo Yoon Seo-Yun Jang So-Won Heo Geonha Park Young-Pyo Jang Hye-Shin Ahn Yu-Kyong Shin Sun-Hee Lee Kyung-Tae Lee Dieckol Isolated from <i>Eisenia bicyclis</i> Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless Mice Marine Drugs dieckol photoaging ultraviolet B MMPs collagen MAPK |
| title | Dieckol Isolated from <i>Eisenia bicyclis</i> Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless Mice |
| title_full | Dieckol Isolated from <i>Eisenia bicyclis</i> Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless Mice |
| title_fullStr | Dieckol Isolated from <i>Eisenia bicyclis</i> Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless Mice |
| title_full_unstemmed | Dieckol Isolated from <i>Eisenia bicyclis</i> Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless Mice |
| title_short | Dieckol Isolated from <i>Eisenia bicyclis</i> Ameliorates Wrinkling and Improves Skin Hydration via MAPK/AP-1 and TGF-β/Smad Signaling Pathways in UVB-Irradiated Hairless Mice |
| title_sort | dieckol isolated from i eisenia bicyclis i ameliorates wrinkling and improves skin hydration via mapk ap 1 and tgf β smad signaling pathways in uvb irradiated hairless mice |
| topic | dieckol photoaging ultraviolet B MMPs collagen MAPK |
| url | https://www.mdpi.com/1660-3397/20/12/779 |
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