Association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertension
Background: Studies assessing the concordance of albuminuria and retinal microvascular dysfunction (RMD) in type 2 diabetes (T2D) have yielded inconsistent results. Similar to ethnicity, hypertension may be a potential explanatory variable. We compared the association between albuminuria and RMD in...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Diabetes Epidemiology and Management |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666970623000124 |
| _version_ | 1827889883983642624 |
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| author | Charles Antwi-Boasiako Kwaku Amponsah Obeng Kwesi Nyan Amissah-Arthur Latif Musah Benjamin Abaidoo Henry Wedoi Awuviri Joseph Agyapong Abbey Pelagia Awula Ruth Korkor Tei Charles Agyemang Albert.G.B. Amoah Charles F. Hayfron-Benjamin |
| author_facet | Charles Antwi-Boasiako Kwaku Amponsah Obeng Kwesi Nyan Amissah-Arthur Latif Musah Benjamin Abaidoo Henry Wedoi Awuviri Joseph Agyapong Abbey Pelagia Awula Ruth Korkor Tei Charles Agyemang Albert.G.B. Amoah Charles F. Hayfron-Benjamin |
| author_sort | Charles Antwi-Boasiako |
| collection | DOAJ |
| description | Background: Studies assessing the concordance of albuminuria and retinal microvascular dysfunction (RMD) in type 2 diabetes (T2D) have yielded inconsistent results. Similar to ethnicity, hypertension may be a potential explanatory variable. We compared the association between albuminuria and RMD in West Africans with T2D with and without hypertension. Materials and methods: This was a cross-sectional study among 177 systematically sampled Ghanaians with T2D aged ≥ 35 years. Albuminuria was based on urinary albumin-creatinine ratio≥30 mg/g. Retinal images were analyzed and graded according to the Early Treatment Diabetic Retinopathy Study criteria. Logistic regression was used to examine the associations of albuminuria and RMD with adjustments for age, sex, socioeconomic status, diabetes duration, HbA1c, smoking, systolic blood pressure (BP), BMI, and total cholesterol. Results: RMD was more prevalent in individuals with albuminuria than in those without albuminuria (41.7% vs. 24.0%, p = 0.026). In the fully adjusted model, albuminuria remained significantly associated with RMD (odds ratio 2.41[95% CI:1.00–5.80], p = 0.049); the association between albuminuria and RMD was more pronounced in individuals with hypertension (3.10 [1.01–9.50], 0.048) than without hypertension (1.70[0.33–8.77],0.523). In analyses stratified by BP control, albuminuria was significantly associated with RMD in individuals with suboptimal BP (2.76[1.07–7.14], 0.037) but not in individuals with optimal BP (0.24[0.00–17.04],0.512) Conclusion: Our study shows positive associations between albuminuria and RMD among West Africans with T2D, with the strength of association, accentuated in individuals with hypertension/suboptimal BP. Future studies could further characterize the role of hypertension in the associations between albuminuria and RMD. |
| first_indexed | 2024-03-12T21:02:13Z |
| format | Article |
| id | doaj.art-a40c9d1026b04642821efa4e587c4bd9 |
| institution | Directory Open Access Journal |
| issn | 2666-9706 |
| language | English |
| last_indexed | 2024-03-12T21:02:13Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Diabetes Epidemiology and Management |
| spelling | doaj.art-a40c9d1026b04642821efa4e587c4bd92023-07-31T04:09:27ZengElsevierDiabetes Epidemiology and Management2666-97062023-07-0111100139Association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertensionCharles Antwi-Boasiako0Kwaku Amponsah Obeng1Kwesi Nyan Amissah-Arthur2Latif Musah3Benjamin Abaidoo4Henry Wedoi Awuviri5Joseph Agyapong Abbey6Pelagia Awula7Ruth Korkor Tei8Charles Agyemang9Albert.G.B. Amoah10Charles F. Hayfron-Benjamin11Department of Physiology, University of Ghana Medical School, GhanaDepartment of Physiology, University of Ghana Medical School, GhanaOphthalmology Unit, Department of Surgery, Korle Bu Teaching Hospital and University of Ghana Medical School, GhanaDepartment of Physiology, University of Ghana Medical School, GhanaOphthalmology Unit, Department of Surgery, Korle Bu Teaching Hospital and University of Ghana Medical School, GhanaDepartment of Physiology, University of Ghana Medical School, GhanaDepartment of Physiology, University of Ghana Medical School, GhanaDepartment of Physiology, University of Ghana Medical School, GhanaDepartment of Medicine and Therapeutics, University of Ghana Medical School, GhanaDepartment of Public Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the NetherlandsDepartment of Medicine and Therapeutics, University of Ghana Medical School, GhanaDepartment of Physiology, University of Ghana Medical School, Ghana; Department of Public Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands; Department of Internal and Vascular Medicine, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, Amsterdam, the Netherlands; Department of Anaesthesia and Critical Care, Korle Bu Teaching Hospital and University of Ghana Medical School, Ghana; Corresponding author at: Amsterdam UMC, University of Amsterdam, the Netherlands. P O Box DC 605, Dansoman, Accra, Ghana.Background: Studies assessing the concordance of albuminuria and retinal microvascular dysfunction (RMD) in type 2 diabetes (T2D) have yielded inconsistent results. Similar to ethnicity, hypertension may be a potential explanatory variable. We compared the association between albuminuria and RMD in West Africans with T2D with and without hypertension. Materials and methods: This was a cross-sectional study among 177 systematically sampled Ghanaians with T2D aged ≥ 35 years. Albuminuria was based on urinary albumin-creatinine ratio≥30 mg/g. Retinal images were analyzed and graded according to the Early Treatment Diabetic Retinopathy Study criteria. Logistic regression was used to examine the associations of albuminuria and RMD with adjustments for age, sex, socioeconomic status, diabetes duration, HbA1c, smoking, systolic blood pressure (BP), BMI, and total cholesterol. Results: RMD was more prevalent in individuals with albuminuria than in those without albuminuria (41.7% vs. 24.0%, p = 0.026). In the fully adjusted model, albuminuria remained significantly associated with RMD (odds ratio 2.41[95% CI:1.00–5.80], p = 0.049); the association between albuminuria and RMD was more pronounced in individuals with hypertension (3.10 [1.01–9.50], 0.048) than without hypertension (1.70[0.33–8.77],0.523). In analyses stratified by BP control, albuminuria was significantly associated with RMD in individuals with suboptimal BP (2.76[1.07–7.14], 0.037) but not in individuals with optimal BP (0.24[0.00–17.04],0.512) Conclusion: Our study shows positive associations between albuminuria and RMD among West Africans with T2D, with the strength of association, accentuated in individuals with hypertension/suboptimal BP. Future studies could further characterize the role of hypertension in the associations between albuminuria and RMD.http://www.sciencedirect.com/science/article/pii/S2666970623000124DiabetesMicrovascular diseaseAlbuminuriaNephropathyRetinopathyWest Africans |
| spellingShingle | Charles Antwi-Boasiako Kwaku Amponsah Obeng Kwesi Nyan Amissah-Arthur Latif Musah Benjamin Abaidoo Henry Wedoi Awuviri Joseph Agyapong Abbey Pelagia Awula Ruth Korkor Tei Charles Agyemang Albert.G.B. Amoah Charles F. Hayfron-Benjamin Association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertension Diabetes Epidemiology and Management Diabetes Microvascular disease Albuminuria Nephropathy Retinopathy West Africans |
| title | Association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertension |
| title_full | Association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertension |
| title_fullStr | Association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertension |
| title_full_unstemmed | Association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertension |
| title_short | Association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertension |
| title_sort | association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertension |
| topic | Diabetes Microvascular disease Albuminuria Nephropathy Retinopathy West Africans |
| url | http://www.sciencedirect.com/science/article/pii/S2666970623000124 |
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