Effectiveness, Tolerability and Safety of a Compound Based on D-chiro-inositol + Myo-inositol, Melatonin, Folic Acid, and Vitamin D in Patients with Menstrual Cycle Disorders
Background: Menstrual cycle disorders represent a prevalent cause for gynecological consultations. These disorders often encompass ovulatory dysfunction, accompanied by analytical and clinical anomalies linked to hyperandrogenism, collectively defining polycystic ovary syndrome (PCOS). However, a co...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2024-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102035 |
| _version_ | 1797290980803608576 |
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| author | Silvia P. González María del Mar Rubio Helena Losa |
| author_facet | Silvia P. González María del Mar Rubio Helena Losa |
| author_sort | Silvia P. González |
| collection | DOAJ |
| description | Background: Menstrual cycle disorders represent a prevalent cause for gynecological consultations. These disorders often encompass ovulatory dysfunction, accompanied by analytical and clinical anomalies linked to hyperandrogenism, collectively defining polycystic ovary syndrome (PCOS). However, a considerable subset of patients suffering from menstrual cycle disorders fails to meet the diagnostic criteria for any recognized PCOS phenotypes, leading to substantial debate in the field. This study aims to assess the impact of a commercially available combination of inositols, melatonin, folic acid, and vitamin D in patients experiencing menstrual disorders, characterized by oligo-anovulation (amenorrhea and abnormally long cycles), irrespective of their actual compliance with PCOS criteria. Methods: An observational, prospective, non-randomized study was devised to assess cycle regularity, satisfaction levels, and analytical alterations following the administration of the combination of inositols, melatonin, folic acid, and vitamin D (at baseline and at 6 months). Statistical analysis was executed using SPSS (version 22.0). Results: The assessed treatment demonstrated an enhancement in the regularity of menstrual cycles, accompanied by notable reductions in androstenedione and dehydroepiandrosterone (DHEA) levels, as well as basal insulin and the homeostatic model assessment for insulin resistance (HOMA), despite their initial values falling within the normal range. Furthermore, there was a substantial elevation in the serum levels of vitamin D (p < 0.05). Following 6 months of treatment, a high degree of patient satisfaction was observed, with no documented adverse effects within the selected sample. Conclusions: The combination of inositols, melatonin, folic acid, and vitamin D exhibits potential as an efficacious approach for managing menstrual disorders while maintaining a commendable safety profile. Additional investigations into the long-term efficacy and safety of this formulation are warranted, although initial results hold promise. |
| first_indexed | 2024-03-07T19:29:10Z |
| format | Article |
| id | doaj.art-a40ec6e9b4264c4dbb7bb026a0edd088 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-07T19:29:10Z |
| publishDate | 2024-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-a40ec6e9b4264c4dbb7bb026a0edd0882024-02-29T08:28:10ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-02-015123510.31083/j.ceog5102035S0390-6663(23)02245-5Effectiveness, Tolerability and Safety of a Compound Based on D-chiro-inositol + Myo-inositol, Melatonin, Folic Acid, and Vitamin D in Patients with Menstrual Cycle DisordersSilvia P. González0María del Mar Rubio1Helena Losa2Obstetrics and Gynecology Department, HM Gabinete Velázquez, 28001 Madrid, SpainObstetrics and Gynecology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, SpainObstetrics and Gynecology Department, Hospital Álvaro Cunqueiro, 36312 Vigo, SpainBackground: Menstrual cycle disorders represent a prevalent cause for gynecological consultations. These disorders often encompass ovulatory dysfunction, accompanied by analytical and clinical anomalies linked to hyperandrogenism, collectively defining polycystic ovary syndrome (PCOS). However, a considerable subset of patients suffering from menstrual cycle disorders fails to meet the diagnostic criteria for any recognized PCOS phenotypes, leading to substantial debate in the field. This study aims to assess the impact of a commercially available combination of inositols, melatonin, folic acid, and vitamin D in patients experiencing menstrual disorders, characterized by oligo-anovulation (amenorrhea and abnormally long cycles), irrespective of their actual compliance with PCOS criteria. Methods: An observational, prospective, non-randomized study was devised to assess cycle regularity, satisfaction levels, and analytical alterations following the administration of the combination of inositols, melatonin, folic acid, and vitamin D (at baseline and at 6 months). Statistical analysis was executed using SPSS (version 22.0). Results: The assessed treatment demonstrated an enhancement in the regularity of menstrual cycles, accompanied by notable reductions in androstenedione and dehydroepiandrosterone (DHEA) levels, as well as basal insulin and the homeostatic model assessment for insulin resistance (HOMA), despite their initial values falling within the normal range. Furthermore, there was a substantial elevation in the serum levels of vitamin D (p < 0.05). Following 6 months of treatment, a high degree of patient satisfaction was observed, with no documented adverse effects within the selected sample. Conclusions: The combination of inositols, melatonin, folic acid, and vitamin D exhibits potential as an efficacious approach for managing menstrual disorders while maintaining a commendable safety profile. Additional investigations into the long-term efficacy and safety of this formulation are warranted, although initial results hold promise.https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102035myo-inositold-chiro-inositolmelatoninfolic acidvitamin dmenstrual cycle |
| spellingShingle | Silvia P. González María del Mar Rubio Helena Losa Effectiveness, Tolerability and Safety of a Compound Based on D-chiro-inositol + Myo-inositol, Melatonin, Folic Acid, and Vitamin D in Patients with Menstrual Cycle Disorders Clinical and Experimental Obstetrics & Gynecology myo-inositol d-chiro-inositol melatonin folic acid vitamin d menstrual cycle |
| title | Effectiveness, Tolerability and Safety of a Compound Based on D-chiro-inositol + Myo-inositol, Melatonin, Folic Acid, and Vitamin D in Patients with Menstrual Cycle Disorders |
| title_full | Effectiveness, Tolerability and Safety of a Compound Based on D-chiro-inositol + Myo-inositol, Melatonin, Folic Acid, and Vitamin D in Patients with Menstrual Cycle Disorders |
| title_fullStr | Effectiveness, Tolerability and Safety of a Compound Based on D-chiro-inositol + Myo-inositol, Melatonin, Folic Acid, and Vitamin D in Patients with Menstrual Cycle Disorders |
| title_full_unstemmed | Effectiveness, Tolerability and Safety of a Compound Based on D-chiro-inositol + Myo-inositol, Melatonin, Folic Acid, and Vitamin D in Patients with Menstrual Cycle Disorders |
| title_short | Effectiveness, Tolerability and Safety of a Compound Based on D-chiro-inositol + Myo-inositol, Melatonin, Folic Acid, and Vitamin D in Patients with Menstrual Cycle Disorders |
| title_sort | effectiveness tolerability and safety of a compound based on d chiro inositol myo inositol melatonin folic acid and vitamin d in patients with menstrual cycle disorders |
| topic | myo-inositol d-chiro-inositol melatonin folic acid vitamin d menstrual cycle |
| url | https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102035 |
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