Gas‐Shearing Fabrication of Multicompartmental Microspheres: A One‐Step and Oil‐Free Approach
Abstract Multicompartmental microparticles (MCMs) have attracted considerable attention in biomedical engineering and materials sciences, as they can carry multiple materials in the separated phases of a single particle. However, the robust fabrication of monodisperse, highly compartmental MCMs at t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.201802342 |
| _version_ | 1797742398581768192 |
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| author | Guosheng Tang Ranhua Xiong Dan Lv Ronald X. Xu Kevin Braeckmans Chaobo Huang Stefaan C. De Smedt |
| author_facet | Guosheng Tang Ranhua Xiong Dan Lv Ronald X. Xu Kevin Braeckmans Chaobo Huang Stefaan C. De Smedt |
| author_sort | Guosheng Tang |
| collection | DOAJ |
| description | Abstract Multicompartmental microparticles (MCMs) have attracted considerable attention in biomedical engineering and materials sciences, as they can carry multiple materials in the separated phases of a single particle. However, the robust fabrication of monodisperse, highly compartmental MCMs at the micro‐ and nanoscales remains challenging. Here, a simple one‐step and oil‐free process, based on the gas‐flow‐assisted formation of microdroplets (“gas‐shearing”), is established for the scalable production of monodisperse MCMs. By changing the configuration of the needle system and gas flow in the spray ejector device, the oil‐free gas‐shearing process easily allows the design of microparticles consisting of two, four, six, and even eight compartments with a precise control over the properties of each compartment. As oils and surfactants are not used, the gas‐shearing method is highly cytocompatible. The versatile applications of such MCMs are demonstrated by producing a magnetic microrobot and a biocompatible carrier for the coculturing of cells. This research suggests that the oil‐free gas‐shearing strategy is a reliable, scalable, and biofriendly process for producing MCMs that may become attractive materials for biomedical applications. |
| first_indexed | 2024-03-12T14:41:16Z |
| format | Article |
| id | doaj.art-a40f92093a79452d94a05e59881ecf02 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T14:41:16Z |
| publishDate | 2019-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-a40f92093a79452d94a05e59881ecf022023-08-16T08:41:29ZengWileyAdvanced Science2198-38442019-05-0169n/an/a10.1002/advs.201802342Gas‐Shearing Fabrication of Multicompartmental Microspheres: A One‐Step and Oil‐Free ApproachGuosheng Tang0Ranhua Xiong1Dan Lv2Ronald X. Xu3Kevin Braeckmans4Chaobo Huang5Stefaan C. De Smedt6College of Chemical Engineering Jiangsu Key Lab of Biomass‐based Green Fuels and Chemicals Nanjing Forestry University (NFU) Nanjing 210037 P. R. ChinaLaboratory of General Biochemistry and Physical Pharmacy Faculty of Pharmaceutical Sciences Ghent University Ottergemsesteenweg 460 9000 Ghent BelgiumCollege of Chemical Engineering Jiangsu Key Lab of Biomass‐based Green Fuels and Chemicals Nanjing Forestry University (NFU) Nanjing 210037 P. R. ChinaDepartment of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei 230022 P. R. ChinaLaboratory of General Biochemistry and Physical Pharmacy Faculty of Pharmaceutical Sciences Ghent University Ottergemsesteenweg 460 9000 Ghent BelgiumCollege of Chemical Engineering Jiangsu Key Lab of Biomass‐based Green Fuels and Chemicals Nanjing Forestry University (NFU) Nanjing 210037 P. R. ChinaCollege of Chemical Engineering Jiangsu Key Lab of Biomass‐based Green Fuels and Chemicals Nanjing Forestry University (NFU) Nanjing 210037 P. R. ChinaAbstract Multicompartmental microparticles (MCMs) have attracted considerable attention in biomedical engineering and materials sciences, as they can carry multiple materials in the separated phases of a single particle. However, the robust fabrication of monodisperse, highly compartmental MCMs at the micro‐ and nanoscales remains challenging. Here, a simple one‐step and oil‐free process, based on the gas‐flow‐assisted formation of microdroplets (“gas‐shearing”), is established for the scalable production of monodisperse MCMs. By changing the configuration of the needle system and gas flow in the spray ejector device, the oil‐free gas‐shearing process easily allows the design of microparticles consisting of two, four, six, and even eight compartments with a precise control over the properties of each compartment. As oils and surfactants are not used, the gas‐shearing method is highly cytocompatible. The versatile applications of such MCMs are demonstrated by producing a magnetic microrobot and a biocompatible carrier for the coculturing of cells. This research suggests that the oil‐free gas‐shearing strategy is a reliable, scalable, and biofriendly process for producing MCMs that may become attractive materials for biomedical applications.https://doi.org/10.1002/advs.201802342biocompatible carriersgas‐shearingmulticompartmental microspheresone‐step fabricationtissue engineering |
| spellingShingle | Guosheng Tang Ranhua Xiong Dan Lv Ronald X. Xu Kevin Braeckmans Chaobo Huang Stefaan C. De Smedt Gas‐Shearing Fabrication of Multicompartmental Microspheres: A One‐Step and Oil‐Free Approach Advanced Science biocompatible carriers gas‐shearing multicompartmental microspheres one‐step fabrication tissue engineering |
| title | Gas‐Shearing Fabrication of Multicompartmental Microspheres: A One‐Step and Oil‐Free Approach |
| title_full | Gas‐Shearing Fabrication of Multicompartmental Microspheres: A One‐Step and Oil‐Free Approach |
| title_fullStr | Gas‐Shearing Fabrication of Multicompartmental Microspheres: A One‐Step and Oil‐Free Approach |
| title_full_unstemmed | Gas‐Shearing Fabrication of Multicompartmental Microspheres: A One‐Step and Oil‐Free Approach |
| title_short | Gas‐Shearing Fabrication of Multicompartmental Microspheres: A One‐Step and Oil‐Free Approach |
| title_sort | gas shearing fabrication of multicompartmental microspheres a one step and oil free approach |
| topic | biocompatible carriers gas‐shearing multicompartmental microspheres one‐step fabrication tissue engineering |
| url | https://doi.org/10.1002/advs.201802342 |
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