Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects
Although thyroid hormone (TH) has anti-obesity potential, systemic administration of TH causes severe adverse effects without obvious weight loss. Here, the authors show that adipose tissue-targeted delivery of TH with liposomes is a safe and efficient strategy to treat obesity and its related compl...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35470-4 |
| _version_ | 1797977352677883904 |
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| author | Kang Chen Lai Yee Cheong Yuan Gao Yaming Zhang Tianshi Feng Qin Wang Leigang Jin Eric Honoré Karen S. L. Lam Weiping Wang Xiaoyan Hui Aimin Xu |
| author_facet | Kang Chen Lai Yee Cheong Yuan Gao Yaming Zhang Tianshi Feng Qin Wang Leigang Jin Eric Honoré Karen S. L. Lam Weiping Wang Xiaoyan Hui Aimin Xu |
| author_sort | Kang Chen |
| collection | DOAJ |
| description | Although thyroid hormone (TH) has anti-obesity potential, systemic administration of TH causes severe adverse effects without obvious weight loss. Here, the authors show that adipose tissue-targeted delivery of TH with liposomes is a safe and efficient strategy to treat obesity and its related complications in mice. |
| first_indexed | 2024-04-11T05:06:41Z |
| format | Article |
| id | doaj.art-a41188231e854b5bb69ffa79bdacf04d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T05:06:41Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a41188231e854b5bb69ffa79bdacf04d2022-12-25T12:21:20ZengNature PortfolioNature Communications2041-17232022-12-0113112010.1038/s41467-022-35470-4Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effectsKang Chen0Lai Yee Cheong1Yuan Gao2Yaming Zhang3Tianshi Feng4Qin Wang5Leigang Jin6Eric Honoré7Karen S. L. Lam8Weiping Wang9Xiaoyan Hui10Aimin Xu11State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongUniversité Côte d’Azur, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Institut de Pharmacologie Moléculaire et Cellulaire, Labex ICSTState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongAlthough thyroid hormone (TH) has anti-obesity potential, systemic administration of TH causes severe adverse effects without obvious weight loss. Here, the authors show that adipose tissue-targeted delivery of TH with liposomes is a safe and efficient strategy to treat obesity and its related complications in mice.https://doi.org/10.1038/s41467-022-35470-4 |
| spellingShingle | Kang Chen Lai Yee Cheong Yuan Gao Yaming Zhang Tianshi Feng Qin Wang Leigang Jin Eric Honoré Karen S. L. Lam Weiping Wang Xiaoyan Hui Aimin Xu Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects Nature Communications |
| title | Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects |
| title_full | Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects |
| title_fullStr | Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects |
| title_full_unstemmed | Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects |
| title_short | Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects |
| title_sort | adipose targeted triiodothyronine therapy counteracts obesity related metabolic complications and atherosclerosis with negligible side effects |
| url | https://doi.org/10.1038/s41467-022-35470-4 |
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