Human Monocytotropic Ehrlichiosis, Missouri
To determine the incidence, clinical and laboratory characteristics, and utility of molecular diagnosis of human monocytotropic ehrlichiosis (HME) in the primary care setting, we conducted a prospective study in an outpatient primary care clinic in Cape Girardeau, Missouri. One hundred and two patie...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2003-12-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/9/12/02-0733_article |
| _version_ | 1818143905385807872 |
|---|---|
| author | Juan P. Olano Edwin Masters Wayne Hogrefe David H. Walker |
| author_facet | Juan P. Olano Edwin Masters Wayne Hogrefe David H. Walker |
| author_sort | Juan P. Olano |
| collection | DOAJ |
| description | To determine the incidence, clinical and laboratory characteristics, and utility of molecular diagnosis of human monocytotropic ehrlichiosis (HME) in the primary care setting, we conducted a prospective study in an outpatient primary care clinic in Cape Girardeau, Missouri. One hundred and two patients with a history of fever for 3 days (>37.7°C), tick bite or exposure, and no other infectious disease diagnosis were enrolled between March 1997 and December 1999. HME was diagnosed in 29 patients by indirect immunofluorescent antibody assay and polymerase chain reaction (PCR). Clinical and laboratory manifestations included fever (100%), headache (72%), myalgia or arthralgia (69%), chills (45%), weakness (38%), nausea (38%), leukopenia (60%), thrombocytopenia (56%), and elevated aspartate aminotransferase level (52%). Hospitalization occurred in 41% of case-patients. PCR sensitivity was 56%; specificity, 100%. HME is a prevalent, potentially severe disease in southeastern Missouri that often requires hospitalization. Because clinical presentation of HME is nonspecific, PCR is useful in the diagnosis of acute HME. |
| first_indexed | 2024-12-11T11:39:06Z |
| format | Article |
| id | doaj.art-a411f54d637a4949b7aae7759812c56e |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T11:39:06Z |
| publishDate | 2003-12-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-a411f54d637a4949b7aae7759812c56e2022-12-22T01:08:39ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592003-12-019121579158610.3201/eid0912.020733Human Monocytotropic Ehrlichiosis, MissouriJuan P. OlanoEdwin MastersWayne HogrefeDavid H. WalkerTo determine the incidence, clinical and laboratory characteristics, and utility of molecular diagnosis of human monocytotropic ehrlichiosis (HME) in the primary care setting, we conducted a prospective study in an outpatient primary care clinic in Cape Girardeau, Missouri. One hundred and two patients with a history of fever for 3 days (>37.7°C), tick bite or exposure, and no other infectious disease diagnosis were enrolled between March 1997 and December 1999. HME was diagnosed in 29 patients by indirect immunofluorescent antibody assay and polymerase chain reaction (PCR). Clinical and laboratory manifestations included fever (100%), headache (72%), myalgia or arthralgia (69%), chills (45%), weakness (38%), nausea (38%), leukopenia (60%), thrombocytopenia (56%), and elevated aspartate aminotransferase level (52%). Hospitalization occurred in 41% of case-patients. PCR sensitivity was 56%; specificity, 100%. HME is a prevalent, potentially severe disease in southeastern Missouri that often requires hospitalization. Because clinical presentation of HME is nonspecific, PCR is useful in the diagnosis of acute HME.https://wwwnc.cdc.gov/eid/article/9/12/02-0733_articleEhrlichia chaffeensisAnaplasma phagocytophilumEhrlichia ewingiihuman monocytotropic ehrlichiosis (HME)human anaplasmosis (formerly known as human granulocytotropic ehrlichiosis or HGE)polymerase chain reaction (PCR) |
| spellingShingle | Juan P. Olano Edwin Masters Wayne Hogrefe David H. Walker Human Monocytotropic Ehrlichiosis, Missouri Emerging Infectious Diseases Ehrlichia chaffeensis Anaplasma phagocytophilum Ehrlichia ewingii human monocytotropic ehrlichiosis (HME) human anaplasmosis (formerly known as human granulocytotropic ehrlichiosis or HGE) polymerase chain reaction (PCR) |
| title | Human Monocytotropic Ehrlichiosis, Missouri |
| title_full | Human Monocytotropic Ehrlichiosis, Missouri |
| title_fullStr | Human Monocytotropic Ehrlichiosis, Missouri |
| title_full_unstemmed | Human Monocytotropic Ehrlichiosis, Missouri |
| title_short | Human Monocytotropic Ehrlichiosis, Missouri |
| title_sort | human monocytotropic ehrlichiosis missouri |
| topic | Ehrlichia chaffeensis Anaplasma phagocytophilum Ehrlichia ewingii human monocytotropic ehrlichiosis (HME) human anaplasmosis (formerly known as human granulocytotropic ehrlichiosis or HGE) polymerase chain reaction (PCR) |
| url | https://wwwnc.cdc.gov/eid/article/9/12/02-0733_article |
| work_keys_str_mv | AT juanpolano humanmonocytotropicehrlichiosismissouri AT edwinmasters humanmonocytotropicehrlichiosismissouri AT waynehogrefe humanmonocytotropicehrlichiosismissouri AT davidhwalker humanmonocytotropicehrlichiosismissouri |