Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus

Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus

IntroductionMost childhood-onset SLE patients (cSLE) develop lupus nephritis (cLN), but only a small proportion achieve complete response to current therapies. The prognosis of children with LN and end-stage renal disease is particularly dire. Mortality rates within the first five years of renal rep...

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Bibliographic Details
Main Authors: Ryan M. Baxter, Christine S. Wang, Josselyn E. Garcia-Perez, Daniel S. Kong, Brianne M. Coleman, Valentyna Larchenko, Ronald P. Schuyler, Conner Jackson, Tusharkanti Ghosh, Pratyaydipta Rudra, Debdas Paul, Manfred Claassen, Rosemary Rochford, John C. Cambier, Debashis Ghosh, Jennifer C. Cooper, Mia J. Smith, Elena W. Y. Hsieh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
SLE
nephritis
CyTOF
interferon
anergic B cells
T peripheral helper cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1208282/full

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