Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer
Colorectal cancer is the second most common cancer diagnosed in men and the third most commonly occurring in women worldwide. Interactions between cells and the surrounding extracellular matrix (ECM) are involved in tumor development and progression of many types of cancer. The organization of the E...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00527/full |
| _version_ | 1818387606063284224 |
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| author | Cuong Cao Le Cuong Cao Le Cuong Cao Le Amar Bennasroune Amar Bennasroune Benoit Langlois Benoit Langlois Stéphanie Salesse Stéphanie Salesse Camille Boulagnon-Rombi Camille Boulagnon-Rombi Camille Boulagnon-Rombi Hamid Morjani Hamid Morjani Stéphane Dedieu Stéphane Dedieu Aline Appert-Collin Aline Appert-Collin |
| author_facet | Cuong Cao Le Cuong Cao Le Cuong Cao Le Amar Bennasroune Amar Bennasroune Benoit Langlois Benoit Langlois Stéphanie Salesse Stéphanie Salesse Camille Boulagnon-Rombi Camille Boulagnon-Rombi Camille Boulagnon-Rombi Hamid Morjani Hamid Morjani Stéphane Dedieu Stéphane Dedieu Aline Appert-Collin Aline Appert-Collin |
| author_sort | Cuong Cao Le |
| collection | DOAJ |
| description | Colorectal cancer is the second most common cancer diagnosed in men and the third most commonly occurring in women worldwide. Interactions between cells and the surrounding extracellular matrix (ECM) are involved in tumor development and progression of many types of cancer. The organization of the ECM molecules provides not only physical scaffoldings and dynamic network into which cells are embedded but also allows the control of many cellular behaviors including proliferation, migration, differentiation, and survival leading to homeostasis and morphogenesis regulation. Modifications of ECM composition and mechanical properties during carcinogenesis are critical for tumor initiation and progression. The core matrisome consists of five classes of macromolecules, which are collagens, laminins, fibronectin, proteoglycans, and hyaluronans. In most tissues, fibrillar collagen is the major component of ECM. Cells embedded into fibrillar collagen interact with it through their surface receptors, such as integrins and discoidin domain receptors (DDRs). On the one hand, cells incorporate signals from ECM that modify their functionalities and behaviors. On the other hand, all cells within tumor environment (cancer cells, cancer-associated fibroblasts, endothelial cells, and immune cells) synthesize and secrete matrix macromolecules under the control of multiple extracellular signals. This cell-ECM dialog participates in a dynamic way in ECM formation and its biophysical and biochemical properties. Here, we will review the functional interplay between cells and collagen network within the tumor microenvironment during colorectal cancer progression. |
| first_indexed | 2024-12-14T04:12:37Z |
| format | Article |
| id | doaj.art-a416d3737de0437ca88cd7e5148db55d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T04:12:37Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a416d3737de0437ca88cd7e5148db55d2022-12-21T23:17:38ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-04-011010.3389/fonc.2020.00527527981Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal CancerCuong Cao Le0Cuong Cao Le1Cuong Cao Le2Amar Bennasroune3Amar Bennasroune4Benoit Langlois5Benoit Langlois6Stéphanie Salesse7Stéphanie Salesse8Camille Boulagnon-Rombi9Camille Boulagnon-Rombi10Camille Boulagnon-Rombi11Hamid Morjani12Hamid Morjani13Stéphane Dedieu14Stéphane Dedieu15Aline Appert-Collin16Aline Appert-Collin17Université de Reims Champagne-Ardenne, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire, MEDyC, Reims, FranceUnité BioSpecT, EA7506, Reims, FranceUniversité de Reims Champagne-Ardenne, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire, MEDyC, Reims, FranceUniversité de Reims Champagne-Ardenne, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire, MEDyC, Reims, FranceUniversité de Reims Champagne-Ardenne, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire, MEDyC, Reims, FranceUniversité de Reims Champagne-Ardenne, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire, MEDyC, Reims, FranceLaboratoire de Biopathologie, Centre Hospitalier Universitaire et Faculté de Médecine, Reims, FranceUniversité de Reims Champagne-Ardenne, Reims, FranceUnité BioSpecT, EA7506, Reims, FranceUniversité de Reims Champagne-Ardenne, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire, MEDyC, Reims, FranceUniversité de Reims Champagne-Ardenne, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire, MEDyC, Reims, FranceColorectal cancer is the second most common cancer diagnosed in men and the third most commonly occurring in women worldwide. Interactions between cells and the surrounding extracellular matrix (ECM) are involved in tumor development and progression of many types of cancer. The organization of the ECM molecules provides not only physical scaffoldings and dynamic network into which cells are embedded but also allows the control of many cellular behaviors including proliferation, migration, differentiation, and survival leading to homeostasis and morphogenesis regulation. Modifications of ECM composition and mechanical properties during carcinogenesis are critical for tumor initiation and progression. The core matrisome consists of five classes of macromolecules, which are collagens, laminins, fibronectin, proteoglycans, and hyaluronans. In most tissues, fibrillar collagen is the major component of ECM. Cells embedded into fibrillar collagen interact with it through their surface receptors, such as integrins and discoidin domain receptors (DDRs). On the one hand, cells incorporate signals from ECM that modify their functionalities and behaviors. On the other hand, all cells within tumor environment (cancer cells, cancer-associated fibroblasts, endothelial cells, and immune cells) synthesize and secrete matrix macromolecules under the control of multiple extracellular signals. This cell-ECM dialog participates in a dynamic way in ECM formation and its biophysical and biochemical properties. Here, we will review the functional interplay between cells and collagen network within the tumor microenvironment during colorectal cancer progression.https://www.frontiersin.org/article/10.3389/fonc.2020.00527/fullcolorectal cancercollagencancer-associated fibroblasttumor cellendothelial cellin vitro model |
| spellingShingle | Cuong Cao Le Cuong Cao Le Cuong Cao Le Amar Bennasroune Amar Bennasroune Benoit Langlois Benoit Langlois Stéphanie Salesse Stéphanie Salesse Camille Boulagnon-Rombi Camille Boulagnon-Rombi Camille Boulagnon-Rombi Hamid Morjani Hamid Morjani Stéphane Dedieu Stéphane Dedieu Aline Appert-Collin Aline Appert-Collin Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer Frontiers in Oncology colorectal cancer collagen cancer-associated fibroblast tumor cell endothelial cell in vitro model |
| title | Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer |
| title_full | Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer |
| title_fullStr | Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer |
| title_full_unstemmed | Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer |
| title_short | Functional Interplay Between Collagen Network and Cell Behavior Within Tumor Microenvironment in Colorectal Cancer |
| title_sort | functional interplay between collagen network and cell behavior within tumor microenvironment in colorectal cancer |
| topic | colorectal cancer collagen cancer-associated fibroblast tumor cell endothelial cell in vitro model |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00527/full |
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