Efficient Killing of Murine Pluripotent Stem Cells by Natural Killer (NK) Cells Requires Activation by Cytokines and Partly Depends on the Activating NK Receptor NKG2D

Efficient Killing of Murine Pluripotent Stem Cells by Natural Killer (NK) Cells Requires Activation by Cytokines and Partly Depends on the Activating NK Receptor NKG2D

Natural killer (NK) cells play an important role as cytotoxic effector cells, which scan the organism for infected or tumorigenic cells. Conflicting data have been published whether NK cells can also kill allogeneic or even autologous pluripotent stem cells (PSCs) and which receptors are involved. A...

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Bibliographic Details
Main Authors: Carina Gröschel, Daniela Hübscher, Jessica Nolte, Sebastian Monecke, André Sasse, Leslie Elsner, Walter Paulus, Claudia Trenkwalder, Bojan Polić, Ahmed Mansouri, Kaomei Guan, Ralf Dressel
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
teratoma
autologous transplantation
embryonic stem cells
induced pluripotent stem cells
multipotent adult germline stem cells
natural killer cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00870/full

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