Morphology of the anterior mesorectum: a new predictor for local recurrence in patients with rectal cancer
Abstract. Background:. Pre-operative assessment with high-resolution magnetic resonance imaging (MRI) is useful for assessing the risk of local recurrence (LR) and survival in rectal cancer. However, few studies have explored the clinical importance of the morphology of the anterior mesorectum, espe...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2022-10-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002024 |
| _version_ | 1797840224551698432 |
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| author | Xiaojie Wang Zhifang Zheng Min Chen Jing Lin Xingrong Lu Ying Huang Shenghui Huang Pan Chi Yanjie Yin Xiuyuan Hao |
| author_facet | Xiaojie Wang Zhifang Zheng Min Chen Jing Lin Xingrong Lu Ying Huang Shenghui Huang Pan Chi Yanjie Yin Xiuyuan Hao |
| author_sort | Xiaojie Wang |
| collection | DOAJ |
| description | Abstract. Background:. Pre-operative assessment with high-resolution magnetic resonance imaging (MRI) is useful for assessing the risk of local recurrence (LR) and survival in rectal cancer. However, few studies have explored the clinical importance of the morphology of the anterior mesorectum, especially in patients with anterior cancer. Hence, the study aimed to investigate the impact of the morphology of the anterior mesorectum on LR in patients with primary rectal cancer.
Methods:. A retrospective study was performed on 176 patients who underwent neoadjuvant treatment and curative-intent surgery. Patients were divided into two groups according to the morphology of the anterior mesorectum on sagittal MRI: (1) linear type: the anterior mesorectum was thin and linear; and (2) triangular type: the anterior mesorectum was thick and had a unique triangular shape. Clinicopathological and LR data were compared between patients with linear type anterior mesorectal morphology and patients with triangular type anterior mesorectal morphology.
Results:. Morphometric analysis showed that 90 (51.1%) patients had linear type anterior mesorectal morphology, while 86 (48.9%) had triangular type anterior mesorectal morphology. Compared to triangular type anterior mesorectal morphology, linear type anterior mesorectal morphology was more common in females and was associated with a higher risk of circumferential resection margin involvement measured by MRI (35.6% [32/90] vs. 16.3% [14/86], P = 0.004) and a higher 5-year LR rate (12.2% vs. 3.5%, P = 0.030). In addition, the combination of linear type anterior mesorectal morphology and anterior tumors was confirmed as an independent risk factor for LR (odds ratio = 4.283, P = 0.014).
Conclusions:. The classification established in this study was a simple way to describe morphological characteristics of the anterior mesorectum. The combination of linear type anterior mesorectal morphology and anterior tumors was an independent risk factor for LR and may act as a tool to assist with LR risk stratification and treatment selection. |
| first_indexed | 2024-04-09T16:11:26Z |
| format | Article |
| id | doaj.art-a41981c3798c4dd7989fdf6922341cf4 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-04-09T16:11:26Z |
| publishDate | 2022-10-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-a41981c3798c4dd7989fdf6922341cf42023-04-24T10:02:46ZengWolters KluwerChinese Medical Journal0366-69992542-56412022-10-01135202453246010.1097/CM9.0000000000002024202210200-00008Morphology of the anterior mesorectum: a new predictor for local recurrence in patients with rectal cancerXiaojie WangZhifang ZhengMin ChenJing LinXingrong LuYing HuangShenghui HuangPan ChiYanjie YinXiuyuan HaoAbstract. Background:. Pre-operative assessment with high-resolution magnetic resonance imaging (MRI) is useful for assessing the risk of local recurrence (LR) and survival in rectal cancer. However, few studies have explored the clinical importance of the morphology of the anterior mesorectum, especially in patients with anterior cancer. Hence, the study aimed to investigate the impact of the morphology of the anterior mesorectum on LR in patients with primary rectal cancer. Methods:. A retrospective study was performed on 176 patients who underwent neoadjuvant treatment and curative-intent surgery. Patients were divided into two groups according to the morphology of the anterior mesorectum on sagittal MRI: (1) linear type: the anterior mesorectum was thin and linear; and (2) triangular type: the anterior mesorectum was thick and had a unique triangular shape. Clinicopathological and LR data were compared between patients with linear type anterior mesorectal morphology and patients with triangular type anterior mesorectal morphology. Results:. Morphometric analysis showed that 90 (51.1%) patients had linear type anterior mesorectal morphology, while 86 (48.9%) had triangular type anterior mesorectal morphology. Compared to triangular type anterior mesorectal morphology, linear type anterior mesorectal morphology was more common in females and was associated with a higher risk of circumferential resection margin involvement measured by MRI (35.6% [32/90] vs. 16.3% [14/86], P = 0.004) and a higher 5-year LR rate (12.2% vs. 3.5%, P = 0.030). In addition, the combination of linear type anterior mesorectal morphology and anterior tumors was confirmed as an independent risk factor for LR (odds ratio = 4.283, P = 0.014). Conclusions:. The classification established in this study was a simple way to describe morphological characteristics of the anterior mesorectum. The combination of linear type anterior mesorectal morphology and anterior tumors was an independent risk factor for LR and may act as a tool to assist with LR risk stratification and treatment selection.http://journals.lww.com/10.1097/CM9.0000000000002024 |
| spellingShingle | Xiaojie Wang Zhifang Zheng Min Chen Jing Lin Xingrong Lu Ying Huang Shenghui Huang Pan Chi Yanjie Yin Xiuyuan Hao Morphology of the anterior mesorectum: a new predictor for local recurrence in patients with rectal cancer Chinese Medical Journal |
| title | Morphology of the anterior mesorectum: a new predictor for local recurrence in patients with rectal cancer |
| title_full | Morphology of the anterior mesorectum: a new predictor for local recurrence in patients with rectal cancer |
| title_fullStr | Morphology of the anterior mesorectum: a new predictor for local recurrence in patients with rectal cancer |
| title_full_unstemmed | Morphology of the anterior mesorectum: a new predictor for local recurrence in patients with rectal cancer |
| title_short | Morphology of the anterior mesorectum: a new predictor for local recurrence in patients with rectal cancer |
| title_sort | morphology of the anterior mesorectum a new predictor for local recurrence in patients with rectal cancer |
| url | http://journals.lww.com/10.1097/CM9.0000000000002024 |
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