Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress
The immunomodulatory effects of live or non-viable lactic acid bacteria have been extensively investigated. We reported that oral intake of heat-killed Lactobacillus plantarum L-137 (HK L-137) augmented innate and acquired immunity in mice and human subjects. To examine the effects of HK L-137 intak...
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Cambridge University Press
2013-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679013000359/type/journal_article |
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| author | Yoshitaka Hirose Yoshihiro Yamamoto Yasunobu Yoshikai Shinji Murosaki |
| author_facet | Yoshitaka Hirose Yoshihiro Yamamoto Yasunobu Yoshikai Shinji Murosaki |
| author_sort | Yoshitaka Hirose |
| collection | DOAJ |
| description | The immunomodulatory effects of live or non-viable lactic acid bacteria have been extensively investigated. We reported that oral intake of heat-killed Lactobacillus plantarum L-137 (HK L-137) augmented innate and acquired immunity in mice and human subjects. To examine the effects of HK L-137 intake on upper respiratory tract infection (URTI) symptoms and immune functions in human subjects, a randomised, double-blind, placebo-controlled, parallel study was conducted in subjects with high psychological stress levels. A total of seventy-eight healthy subjects (thirty-three men and forty-five women; mean age 50·6 years) with scores of >41 on eighteen-item subscales of psychological distress in the Brief Job Stress Questionnaire were randomly assigned to receive a tablet containing HK L-137 (10 mg) or a placebo tablet daily for 12 weeks. The URTI symptoms were rated once daily on the validated twenty-one-item Wisconsin Upper Respiratory Symptom Survey-21. Immune functions, such as concanavalin A-induced proliferation and percentages of interferon (IFN)-γ- and IL-4-producing CD4 T cells of peripheral blood mononuclear cells (PBMC), and serum IFN-β concentrations were measured every 4 weeks. URTI incidence was significantly lower in the HK L-137 group than in the control group. URTI incidence, duration and severity, and duration of medication showed significant negative correlations with duration of HK L-137 intake. The percentage change from baseline of concanavalin A-induced proliferation of PBMC was significantly greater in the HK L-137 group than in the control group. These findings suggest that daily HK L-137 intake can decrease URTI incidence in healthy subjects, possibly through augmentation of immune functions. |
| first_indexed | 2024-04-10T04:44:11Z |
| format | Article |
| id | doaj.art-a419bf320a02432d9ab55ac67f51cdb8 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:44:11Z |
| publishDate | 2013-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-a419bf320a02432d9ab55ac67f51cdb82023-03-09T12:38:38ZengCambridge University PressJournal of Nutritional Science2048-67902013-01-01210.1017/jns.2013.35Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stressYoshitaka Hirose0Yoshihiro Yamamoto1Yasunobu Yoshikai2Shinji Murosaki3Research and Development Institute, House Wellness Foods Corp., Itami, JapanResearch and Development Institute, House Wellness Foods Corp., Itami, JapanResearch Center for Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Kyushu, JapanResearch and Development Institute, House Wellness Foods Corp., Itami, JapanThe immunomodulatory effects of live or non-viable lactic acid bacteria have been extensively investigated. We reported that oral intake of heat-killed Lactobacillus plantarum L-137 (HK L-137) augmented innate and acquired immunity in mice and human subjects. To examine the effects of HK L-137 intake on upper respiratory tract infection (URTI) symptoms and immune functions in human subjects, a randomised, double-blind, placebo-controlled, parallel study was conducted in subjects with high psychological stress levels. A total of seventy-eight healthy subjects (thirty-three men and forty-five women; mean age 50·6 years) with scores of >41 on eighteen-item subscales of psychological distress in the Brief Job Stress Questionnaire were randomly assigned to receive a tablet containing HK L-137 (10 mg) or a placebo tablet daily for 12 weeks. The URTI symptoms were rated once daily on the validated twenty-one-item Wisconsin Upper Respiratory Symptom Survey-21. Immune functions, such as concanavalin A-induced proliferation and percentages of interferon (IFN)-γ- and IL-4-producing CD4 T cells of peripheral blood mononuclear cells (PBMC), and serum IFN-β concentrations were measured every 4 weeks. URTI incidence was significantly lower in the HK L-137 group than in the control group. URTI incidence, duration and severity, and duration of medication showed significant negative correlations with duration of HK L-137 intake. The percentage change from baseline of concanavalin A-induced proliferation of PBMC was significantly greater in the HK L-137 group than in the control group. These findings suggest that daily HK L-137 intake can decrease URTI incidence in healthy subjects, possibly through augmentation of immune functions.https://www.cambridge.org/core/product/identifier/S2048679013000359/type/journal_article Lactobacillus plantarum Immune functionWisconsin Upper Respiratory Symptom SurveyUpper respiratory tract infectionsStress |
| spellingShingle | Yoshitaka Hirose Yoshihiro Yamamoto Yasunobu Yoshikai Shinji Murosaki Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress Journal of Nutritional Science Lactobacillus plantarum Immune function Wisconsin Upper Respiratory Symptom Survey Upper respiratory tract infections Stress |
| title | Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress |
| title_full | Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress |
| title_fullStr | Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress |
| title_full_unstemmed | Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress |
| title_short | Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress |
| title_sort | oral intake of heat killed lactobacillus plantarum l 137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress |
| topic | Lactobacillus plantarum Immune function Wisconsin Upper Respiratory Symptom Survey Upper respiratory tract infections Stress |
| url | https://www.cambridge.org/core/product/identifier/S2048679013000359/type/journal_article |
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