DAPT plus anticoagulant therapy: The difficult coexistence post-ACS in older patients with atrial fibrillation
Atrial fibrillation (AF) and coronary artery disease requiring percutaneous coronary intervention (PCI) and stenting often coexist in older patients. This poses the difficult problem of concurrent anticoagulant and double antiplatelet therapy (triple therapy). Current treatment guidelines do recomme...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2018-06-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/957 |
| _version_ | 1811275984621535232 |
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| author | Mauro Di Bari Alessandra Pratesi Francesca M. Nigro Irene Marozzi Stefano Fumagalli |
| author_facet | Mauro Di Bari Alessandra Pratesi Francesca M. Nigro Irene Marozzi Stefano Fumagalli |
| author_sort | Mauro Di Bari |
| collection | DOAJ |
| description | Atrial fibrillation (AF) and coronary artery disease requiring percutaneous coronary intervention (PCI) and stenting often coexist in older patients. This poses the difficult problem of concurrent anticoagulant and double antiplatelet therapy (triple therapy). Current treatment guidelines do recommend triple therapy, especially in the course of acute coronary syndrome (ACS), with limitations due to an excessive risk of bleeding associated with this therapeutic regimen. This review summarizes randomized clinical trials and observational studies that compared triple therapy with a variety of different therapeutic options. Although the available evidence is not completely satisfactory and other studies are urgently needed, alternative regimens to triple therapy in AF patients undergoing PCI and stenting are promising, at least in terms of safety. |
| first_indexed | 2024-04-12T23:47:18Z |
| format | Article |
| id | doaj.art-a41a006fe8664a49aa0e7742279ca8ba |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-04-12T23:47:18Z |
| publishDate | 2018-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-a41a006fe8664a49aa0e7742279ca8ba2022-12-22T03:11:49ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642018-06-0188210.4081/monaldi.2018.957DAPT plus anticoagulant therapy: The difficult coexistence post-ACS in older patients with atrial fibrillationMauro Di Bari0Alessandra Pratesi1Francesca M. Nigro2Irene Marozzi3Stefano Fumagalli4University of Florence, Department of Experimental and Clinical MedicineUniversity of Florence, Department of Experimental and Clinical MedicineUniversity of Florence, Department of Experimental and Clinical MedicineUniversity of Florence, Department of Experimental and Clinical MedicineUniversity of Florence, Department of Experimental and Clinical MedicineAtrial fibrillation (AF) and coronary artery disease requiring percutaneous coronary intervention (PCI) and stenting often coexist in older patients. This poses the difficult problem of concurrent anticoagulant and double antiplatelet therapy (triple therapy). Current treatment guidelines do recommend triple therapy, especially in the course of acute coronary syndrome (ACS), with limitations due to an excessive risk of bleeding associated with this therapeutic regimen. This review summarizes randomized clinical trials and observational studies that compared triple therapy with a variety of different therapeutic options. Although the available evidence is not completely satisfactory and other studies are urgently needed, alternative regimens to triple therapy in AF patients undergoing PCI and stenting are promising, at least in terms of safety.https://www.monaldi-archives.org/index.php/macd/article/view/957Dual anti-platelet therapytriple therapyacute coronary syndromeatrial fibrillationolder patientshemorrhagic vs thromboembolic risk. |
| spellingShingle | Mauro Di Bari Alessandra Pratesi Francesca M. Nigro Irene Marozzi Stefano Fumagalli DAPT plus anticoagulant therapy: The difficult coexistence post-ACS in older patients with atrial fibrillation Monaldi Archives for Chest Disease Dual anti-platelet therapy triple therapy acute coronary syndrome atrial fibrillation older patients hemorrhagic vs thromboembolic risk. |
| title | DAPT plus anticoagulant therapy: The difficult coexistence post-ACS in older patients with atrial fibrillation |
| title_full | DAPT plus anticoagulant therapy: The difficult coexistence post-ACS in older patients with atrial fibrillation |
| title_fullStr | DAPT plus anticoagulant therapy: The difficult coexistence post-ACS in older patients with atrial fibrillation |
| title_full_unstemmed | DAPT plus anticoagulant therapy: The difficult coexistence post-ACS in older patients with atrial fibrillation |
| title_short | DAPT plus anticoagulant therapy: The difficult coexistence post-ACS in older patients with atrial fibrillation |
| title_sort | dapt plus anticoagulant therapy the difficult coexistence post acs in older patients with atrial fibrillation |
| topic | Dual anti-platelet therapy triple therapy acute coronary syndrome atrial fibrillation older patients hemorrhagic vs thromboembolic risk. |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/957 |
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