The Behavioral Problems in 2.5–5 Years Old Children Linked with Former Neonatal/Infantile Surgical Parameters
Studies report the link between exposure to major neonatal surgery and the risk of later neurodevelopmental disorders. The aim of this study was to find out the behavioral problem scores of 2.5–5 years old children who had undergone median/major non-cardiac surgery before the age of 90 days, and to...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/8/5/423 |
| _version_ | 1797533424376872960 |
|---|---|
| author | Danguolė Rugytė Giedrė Širvinskienė Rima Kregždytė |
| author_facet | Danguolė Rugytė Giedrė Širvinskienė Rima Kregždytė |
| author_sort | Danguolė Rugytė |
| collection | DOAJ |
| description | Studies report the link between exposure to major neonatal surgery and the risk of later neurodevelopmental disorders. The aim of this study was to find out the behavioral problem scores of 2.5–5 years old children who had undergone median/major non-cardiac surgery before the age of 90 days, and to relate these to intraoperative cerebral tissue oxygenation values (rSO<sub>2</sub>), perioperative duration of mechanical ventilation (DMV) and doses of sedative/analgesic agents. Internalizing (IP) and externalizing problems (EP) of 34 children were assessed using the CBCL for ages 1½–5. Median (range) IP and EP scores were 8.5 (2–42) and 15.5 (5–33), respectively and did not correlate with intraoperative rSO<sub>2</sub>. DMV correlated and was predictive for EP (β (95% CI) 0.095 (0.043; 0.148)). An aggregate variable “opioid dose per days of ventilation” was predictive for EP after adjusting for patients’ gestational age and age at the day of psychological assessment, after further adjustment for age at the day of surgery and for cumulative dose of benzodiazepines (β (95% CI 0.009 (0.003; 0.014) and 0.008 (0.002; 0.014), respectively). Neonatal/infantile intraoperative cerebral oxygenation was not associated with later behavioral problems. The risk factors for externalizing problems appeared to be similar to the risk factors in preterm infant population. |
| first_indexed | 2024-03-10T11:14:26Z |
| format | Article |
| id | doaj.art-a420394737804122b815c472197b77bf |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T11:14:26Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-a420394737804122b815c472197b77bf2023-11-21T20:32:30ZengMDPI AGChildren2227-90672021-05-018542310.3390/children8050423The Behavioral Problems in 2.5–5 Years Old Children Linked with Former Neonatal/Infantile Surgical ParametersDanguolė Rugytė0Giedrė Širvinskienė1Rima Kregždytė2Department of Anesthesiology, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaDepartment of Health Psychology, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaDepartment of Preventive Medicine, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaStudies report the link between exposure to major neonatal surgery and the risk of later neurodevelopmental disorders. The aim of this study was to find out the behavioral problem scores of 2.5–5 years old children who had undergone median/major non-cardiac surgery before the age of 90 days, and to relate these to intraoperative cerebral tissue oxygenation values (rSO<sub>2</sub>), perioperative duration of mechanical ventilation (DMV) and doses of sedative/analgesic agents. Internalizing (IP) and externalizing problems (EP) of 34 children were assessed using the CBCL for ages 1½–5. Median (range) IP and EP scores were 8.5 (2–42) and 15.5 (5–33), respectively and did not correlate with intraoperative rSO<sub>2</sub>. DMV correlated and was predictive for EP (β (95% CI) 0.095 (0.043; 0.148)). An aggregate variable “opioid dose per days of ventilation” was predictive for EP after adjusting for patients’ gestational age and age at the day of psychological assessment, after further adjustment for age at the day of surgery and for cumulative dose of benzodiazepines (β (95% CI 0.009 (0.003; 0.014) and 0.008 (0.002; 0.014), respectively). Neonatal/infantile intraoperative cerebral oxygenation was not associated with later behavioral problems. The risk factors for externalizing problems appeared to be similar to the risk factors in preterm infant population.https://www.mdpi.com/2227-9067/8/5/423surgeryneonatesinfantschild behavior checklistinternalizing problemsexternalizing problems |
| spellingShingle | Danguolė Rugytė Giedrė Širvinskienė Rima Kregždytė The Behavioral Problems in 2.5–5 Years Old Children Linked with Former Neonatal/Infantile Surgical Parameters Children surgery neonates infants child behavior checklist internalizing problems externalizing problems |
| title | The Behavioral Problems in 2.5–5 Years Old Children Linked with Former Neonatal/Infantile Surgical Parameters |
| title_full | The Behavioral Problems in 2.5–5 Years Old Children Linked with Former Neonatal/Infantile Surgical Parameters |
| title_fullStr | The Behavioral Problems in 2.5–5 Years Old Children Linked with Former Neonatal/Infantile Surgical Parameters |
| title_full_unstemmed | The Behavioral Problems in 2.5–5 Years Old Children Linked with Former Neonatal/Infantile Surgical Parameters |
| title_short | The Behavioral Problems in 2.5–5 Years Old Children Linked with Former Neonatal/Infantile Surgical Parameters |
| title_sort | behavioral problems in 2 5 5 years old children linked with former neonatal infantile surgical parameters |
| topic | surgery neonates infants child behavior checklist internalizing problems externalizing problems |
| url | https://www.mdpi.com/2227-9067/8/5/423 |
| work_keys_str_mv | AT danguolerugyte thebehavioralproblemsin255yearsoldchildrenlinkedwithformerneonatalinfantilesurgicalparameters AT giedresirvinskiene thebehavioralproblemsin255yearsoldchildrenlinkedwithformerneonatalinfantilesurgicalparameters AT rimakregzdyte thebehavioralproblemsin255yearsoldchildrenlinkedwithformerneonatalinfantilesurgicalparameters AT danguolerugyte behavioralproblemsin255yearsoldchildrenlinkedwithformerneonatalinfantilesurgicalparameters AT giedresirvinskiene behavioralproblemsin255yearsoldchildrenlinkedwithformerneonatalinfantilesurgicalparameters AT rimakregzdyte behavioralproblemsin255yearsoldchildrenlinkedwithformerneonatalinfantilesurgicalparameters |