Genetic Manipulation as a Tool to Unravel <i>Candida parapsilosis</i> Species Complex Virulence and Drug Resistance: State of the Art
An increase in the rate of isolation of <i>Candida parapsilosis</i> in the past decade, as well as increased identification of azole-resistant strains are concerning, and require better understanding of virulence-like factors and drug-resistant traits of these species. In this regard, th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/6/459 |
| _version_ | 1797531027204210688 |
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| author | Marina Zoppo Noemi Poma Mariagrazia Di Luca Daria Bottai Arianna Tavanti |
| author_facet | Marina Zoppo Noemi Poma Mariagrazia Di Luca Daria Bottai Arianna Tavanti |
| author_sort | Marina Zoppo |
| collection | DOAJ |
| description | An increase in the rate of isolation of <i>Candida parapsilosis</i> in the past decade, as well as increased identification of azole-resistant strains are concerning, and require better understanding of virulence-like factors and drug-resistant traits of these species. In this regard, the present review “draws a line” on the information acquired, thus far, on virulence determinants and molecular mechanisms of antifungal resistance in these opportunistic pathogens, mainly derived from genetic manipulation studies. This will provide better focus on where we stand in our understanding of the <i>C. parapsilosis</i> species complex–host interaction, and how far we are from defining potential novel targets or therapeutic strategies—key factors to pave the way for a more tailored management of fungal infections caused by these fungal pathogens. |
| first_indexed | 2024-03-10T10:38:16Z |
| format | Article |
| id | doaj.art-a420d836da6045a6b56ff2b518d5f35e |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T10:38:16Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-a420d836da6045a6b56ff2b518d5f35e2023-11-21T23:10:34ZengMDPI AGJournal of Fungi2309-608X2021-06-017645910.3390/jof7060459Genetic Manipulation as a Tool to Unravel <i>Candida parapsilosis</i> Species Complex Virulence and Drug Resistance: State of the ArtMarina Zoppo0Noemi Poma1Mariagrazia Di Luca2Daria Bottai3Arianna Tavanti4Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, SwitzerlandDepartment of Chemistry and Industrial Chemistry, University of Pisa, 56127 Pisa, ItalyDepartment of Biology, University of Pisa, 56127 Pisa, ItalyDepartment of Biology, University of Pisa, 56127 Pisa, ItalyDepartment of Biology, University of Pisa, 56127 Pisa, ItalyAn increase in the rate of isolation of <i>Candida parapsilosis</i> in the past decade, as well as increased identification of azole-resistant strains are concerning, and require better understanding of virulence-like factors and drug-resistant traits of these species. In this regard, the present review “draws a line” on the information acquired, thus far, on virulence determinants and molecular mechanisms of antifungal resistance in these opportunistic pathogens, mainly derived from genetic manipulation studies. This will provide better focus on where we stand in our understanding of the <i>C. parapsilosis</i> species complex–host interaction, and how far we are from defining potential novel targets or therapeutic strategies—key factors to pave the way for a more tailored management of fungal infections caused by these fungal pathogens.https://www.mdpi.com/2309-608X/7/6/459<i>Candida parapsilosis</i> species complexgenetic manipulationSAT1-flipper cassetteCRISPR/Cas9 systemvirulencedrug resistance |
| spellingShingle | Marina Zoppo Noemi Poma Mariagrazia Di Luca Daria Bottai Arianna Tavanti Genetic Manipulation as a Tool to Unravel <i>Candida parapsilosis</i> Species Complex Virulence and Drug Resistance: State of the Art Journal of Fungi <i>Candida parapsilosis</i> species complex genetic manipulation SAT1-flipper cassette CRISPR/Cas9 system virulence drug resistance |
| title | Genetic Manipulation as a Tool to Unravel <i>Candida parapsilosis</i> Species Complex Virulence and Drug Resistance: State of the Art |
| title_full | Genetic Manipulation as a Tool to Unravel <i>Candida parapsilosis</i> Species Complex Virulence and Drug Resistance: State of the Art |
| title_fullStr | Genetic Manipulation as a Tool to Unravel <i>Candida parapsilosis</i> Species Complex Virulence and Drug Resistance: State of the Art |
| title_full_unstemmed | Genetic Manipulation as a Tool to Unravel <i>Candida parapsilosis</i> Species Complex Virulence and Drug Resistance: State of the Art |
| title_short | Genetic Manipulation as a Tool to Unravel <i>Candida parapsilosis</i> Species Complex Virulence and Drug Resistance: State of the Art |
| title_sort | genetic manipulation as a tool to unravel i candida parapsilosis i species complex virulence and drug resistance state of the art |
| topic | <i>Candida parapsilosis</i> species complex genetic manipulation SAT1-flipper cassette CRISPR/Cas9 system virulence drug resistance |
| url | https://www.mdpi.com/2309-608X/7/6/459 |
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