A Case of Plasma Cell Myeloma with Multilobated and Monocytoid Morphology
Plasma cell myeloma (PCM) accounts for approximately 1% of malignant tumors and 10 to 15% of hematological neoplasms. It is a malignant disease characterized by abnormal proliferation of plasma cells and monoclonal immunoglobulins or free light chains (FLCs). There are many morphological variations...
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2022-09-01
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| Series: | Asian Journal of Oncology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750793 |
| _version_ | 1817983754275127296 |
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| author | Sneha Kakoty Anurag Saha Torsha Jana Jyoti Sawhney |
| author_facet | Sneha Kakoty Anurag Saha Torsha Jana Jyoti Sawhney |
| author_sort | Sneha Kakoty |
| collection | DOAJ |
| description | Plasma cell myeloma (PCM) accounts for approximately 1% of malignant tumors and 10 to 15% of hematological neoplasms. It is a malignant disease characterized by abnormal proliferation of plasma cells and monoclonal immunoglobulins or free light chains (FLCs). There are many morphological variations of the myeloma plasma cells which include mature, immature, plasmablastic, and pleomorphic types. Here, we report a rare presentation of PCM with normal serum protein electrophoresis but elevated serum FLCs and having convoluted, multilobated, and monocytoid morphology. This type of morphology is related to an aggressive clinical course and resistance to conventional chemotherapy. Moreover, absence of M protein in serum/urine electrophoresis does not rule out the diagnosis of PCM and serum FLC assays plays an important role in this kind of scenarios. |
| first_indexed | 2024-04-13T23:37:19Z |
| format | Article |
| id | doaj.art-a422c95dbaa14a18864146ae525c695c |
| institution | Directory Open Access Journal |
| issn | 2454-6798 2455-4618 |
| language | English |
| last_indexed | 2024-04-13T23:37:19Z |
| publishDate | 2022-09-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Asian Journal of Oncology |
| spelling | doaj.art-a422c95dbaa14a18864146ae525c695c2022-12-22T02:24:42ZengThieme Medical Publishers, Inc.Asian Journal of Oncology2454-67982455-46182022-09-01080317217410.1055/s-0042-1750793A Case of Plasma Cell Myeloma with Multilobated and Monocytoid MorphologySneha Kakoty0Anurag Saha1Torsha Jana2Jyoti Sawhney3Department of Oncopathology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, IndiaDepartment of Oncopathology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, IndiaDepartment of Oncopathology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, IndiaDepartment of Oncopathology, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, IndiaPlasma cell myeloma (PCM) accounts for approximately 1% of malignant tumors and 10 to 15% of hematological neoplasms. It is a malignant disease characterized by abnormal proliferation of plasma cells and monoclonal immunoglobulins or free light chains (FLCs). There are many morphological variations of the myeloma plasma cells which include mature, immature, plasmablastic, and pleomorphic types. Here, we report a rare presentation of PCM with normal serum protein electrophoresis but elevated serum FLCs and having convoluted, multilobated, and monocytoid morphology. This type of morphology is related to an aggressive clinical course and resistance to conventional chemotherapy. Moreover, absence of M protein in serum/urine electrophoresis does not rule out the diagnosis of PCM and serum FLC assays plays an important role in this kind of scenarios.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750793light chain myelomamonocytoidmultilobated |
| spellingShingle | Sneha Kakoty Anurag Saha Torsha Jana Jyoti Sawhney A Case of Plasma Cell Myeloma with Multilobated and Monocytoid Morphology Asian Journal of Oncology light chain myeloma monocytoid multilobated |
| title | A Case of Plasma Cell Myeloma with Multilobated and Monocytoid Morphology |
| title_full | A Case of Plasma Cell Myeloma with Multilobated and Monocytoid Morphology |
| title_fullStr | A Case of Plasma Cell Myeloma with Multilobated and Monocytoid Morphology |
| title_full_unstemmed | A Case of Plasma Cell Myeloma with Multilobated and Monocytoid Morphology |
| title_short | A Case of Plasma Cell Myeloma with Multilobated and Monocytoid Morphology |
| title_sort | case of plasma cell myeloma with multilobated and monocytoid morphology |
| topic | light chain myeloma monocytoid multilobated |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750793 |
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