Design, Synthesis, and In Vitro/In Vivo Anti-Cancer Activities of Novel (20<i>S</i>)-10,11-Methylenedioxy-Camptothecin Heterocyclic Derivatives

Design, Synthesis, and In Vitro/In Vivo Anti-Cancer Activities of Novel (20<i>S</i>)-10,11-Methylenedioxy-Camptothecin Heterocyclic Derivatives

A novel camptothecin analogue, (20S)-10,11-methylenedioxy-camptothecin (FL118), has been proven to show significant antitumor efficacy for a wide variety of solid tumors. However, the further development of FL118 is severely hindered due to its extremely poor water solubility and adverse side effect...

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Bibliographic Details
Main Authors: Xiufen Dai, Guanzhao Wu, Yixuan Zhang, Xiaomin Zhang, Ruijuan Yin, Xin Qi, Jing Li, Tao Jiang
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
Camptothecin derivatives
FL118
12e
anticancer agent
molecular design
Online Access:https://www.mdpi.com/1422-0067/21/22/8495

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